Photodegradation of Nabumetone in aqueous solutions
[EN]The photolability of the anti-inflammatory drug Nabumetone (4-(6-methoxy-2-naphthyl)-butan-2-one) was studied in water. The photoproducts were followed by UV-Vis absorption, fluorescence and FTIR spectroscopies as well as gas chromatography–mass spectrometry (GC–MS). The photodegradation process...
| Autores: | , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2003 |
| País: | España |
| Recursos: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:dnet:gredos______::46080e311e2df2194fbbf0b1d336073f |
| Acesso em linha: | http://hdl.handle.net/10366/171029 |
| Access Level: | acceso abierto |
| Palavra-chave: | Nabumetone Photodegradation UV-Vis absorption spectroscopy Fluorescence FTIR spectroscopy Gas chromatography–mass spectrometry Gas Chromatography-Mass Spectrometry cromatografía de gases y espectrometría de masas fluorescencia |
| Resumo: | [EN]The photolability of the anti-inflammatory drug Nabumetone (4-(6-methoxy-2-naphthyl)-butan-2-one) was studied in water. The photoproducts were followed by UV-Vis absorption, fluorescence and FTIR spectroscopies as well as gas chromatography–mass spectrometry (GC–MS). The photodegradation process in water followed first-order kinetics, with an half-life, t1/2 = 9.7min whereas leading to different products. In this medium, the side chain is photoxidised to 6-methoxy-2-naphthalene aldehyde, as major product, probably via a Nabumetone radical cation formation and the addition of singlet oxygen generated in the drug photolysis. In addition the (4-(6-methoxy-2-naphthyl)-3-buten-2-one) was detected. The most likely origin of the unsaturated compound is the dehydratation of an alcoholic derivative in alpha position of the naphthalene ring, produced via the same radical cation. |
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