Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients

Thepancreasfatcontenthasbeenpoorlyinvestigatedinessentialhypertension.Theauthorsaimtorelatepancreasandliverfatcontentwithparametersmeasuringinsulinresistance, beta-cell function and also with markers of endothelial dysfunction andplateletorendothelialcelldestruction.Theauthorsstudiedagroupof40malehy...

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Detalles Bibliográficos
Autores: Alfaro Lara, Verónica Inmaculada, Muñoz Hernández, Rocío, Giménez Miranda, Luis, Beltrán Romero, Luis Matías, Castell Montsalve, Francisco Javier, Stiefel García-Junco, Pablo Enrique
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/156709
Acceso en línea:https://hdl.handle.net/11441/156709
https://doi.org/10.1111/jch.14600
Access Level:acceso abierto
Palabra clave:endothelialdysfunction
endothelialmicroparticle
HOMA
pancreasfatcontent
QUICKI
id ES_72ec941b3cbdb600d7aca30e7dfb5b33
oai_identifier_str oai:idus.us.es:11441/156709
network_acronym_str ES
network_name_str España
repository_id_str
spelling Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patientsAlfaro Lara, Verónica InmaculadaMuñoz Hernández, RocíoGiménez Miranda, LuisBeltrán Romero, Luis MatíasCastell Montsalve, Francisco JavierStiefel García-Junco, Pablo EnriqueendothelialdysfunctionendothelialmicroparticleHOMApancreasfatcontentQUICKIThepancreasfatcontenthasbeenpoorlyinvestigatedinessentialhypertension.Theauthorsaimtorelatepancreasandliverfatcontentwithparametersmeasuringinsulinresistance, beta-cell function and also with markers of endothelial dysfunction andplateletorendothelialcelldestruction.Theauthorsstudiedagroupof40malehyper-tensivepatientswithwell-controlledbloodpressure,maintainingastableweight,andhavingnotchangedtheirmedicationduringthelastyear.Pancreasfatcontentwascor-relatedwithHOMA-IR(r=.616,p<.001),HOMA-S(r=−.439,p<.005),betacellfunctionparameter(r=.457,p<.005),andQUICKI(r=.412,p<.01),whereasliverfatwasnotpatientsinthehighestquartileofpancreasfatcontenthadmorecirculatingendothelialmicroparticlesthanpatientsintheotherquartiles(median129[94.3–200]vs.60.9[49.4–88.8],p=.002).However,patientsinthehighestquartileofthepancreasfat content distribution did not differ from the lowest in hyperemic response afterischemianorcirculatingplateletmicroparticlescount.Liverfatcontentwasnotrelatedto any of the parameters studied. In a multivariate stepwise binary logistic regres-sionanalysis(WaldMethod)circulatingendothelialmicroparticlesremainsignificantlyassociatedwithpancreasfatcontentafteradjustingforconfoundingfactors,suchastobacco,diabetesmellitus,hypercholesterolemia,ormetabolicsyndrome.Ourresultsreflectthatinessentialhypertension,pancreasfatcontentissuperiortoliverfattostudybeta-cellfunctionalityandinsulinresistance.Moreover,theauthorsdescribedforthefirsttimethatpancreasfatcontentisrelatedtoendothelialcelldestruction.Furtherstudiesareneededtoconfirmthispoint.Instituto de Salud Carlos III PI13/01917Wiley Open AccessFisiologíaInstituto de Salud Carlos III2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/156709https://doi.org/10.1111/jch.14600reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésJournal of Clinical Hypertension, 25 (1), 38-46.PI13/01917https://doi.org/10.1111/jch.14600info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1567092026-06-17T12:51:07Z
dc.title.none.fl_str_mv Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients
title Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients
spellingShingle Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients
Alfaro Lara, Verónica Inmaculada
endothelialdysfunction
endothelialmicroparticle
HOMA
pancreasfatcontent
QUICKI
title_short Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients
title_full Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients
title_fullStr Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients
title_full_unstemmed Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients
title_sort Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients
dc.creator.none.fl_str_mv Alfaro Lara, Verónica Inmaculada
Muñoz Hernández, Rocío
Giménez Miranda, Luis
Beltrán Romero, Luis Matías
Castell Montsalve, Francisco Javier
Stiefel García-Junco, Pablo Enrique
author Alfaro Lara, Verónica Inmaculada
author_facet Alfaro Lara, Verónica Inmaculada
Muñoz Hernández, Rocío
Giménez Miranda, Luis
Beltrán Romero, Luis Matías
Castell Montsalve, Francisco Javier
Stiefel García-Junco, Pablo Enrique
author_role author
author2 Muñoz Hernández, Rocío
Giménez Miranda, Luis
Beltrán Romero, Luis Matías
Castell Montsalve, Francisco Javier
Stiefel García-Junco, Pablo Enrique
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Fisiología
Instituto de Salud Carlos III
dc.subject.none.fl_str_mv endothelialdysfunction
endothelialmicroparticle
HOMA
pancreasfatcontent
QUICKI
topic endothelialdysfunction
endothelialmicroparticle
HOMA
pancreasfatcontent
QUICKI
description Thepancreasfatcontenthasbeenpoorlyinvestigatedinessentialhypertension.Theauthorsaimtorelatepancreasandliverfatcontentwithparametersmeasuringinsulinresistance, beta-cell function and also with markers of endothelial dysfunction andplateletorendothelialcelldestruction.Theauthorsstudiedagroupof40malehyper-tensivepatientswithwell-controlledbloodpressure,maintainingastableweight,andhavingnotchangedtheirmedicationduringthelastyear.Pancreasfatcontentwascor-relatedwithHOMA-IR(r=.616,p<.001),HOMA-S(r=−.439,p<.005),betacellfunctionparameter(r=.457,p<.005),andQUICKI(r=.412,p<.01),whereasliverfatwasnotpatientsinthehighestquartileofpancreasfatcontenthadmorecirculatingendothelialmicroparticlesthanpatientsintheotherquartiles(median129[94.3–200]vs.60.9[49.4–88.8],p=.002).However,patientsinthehighestquartileofthepancreasfat content distribution did not differ from the lowest in hyperemic response afterischemianorcirculatingplateletmicroparticlescount.Liverfatcontentwasnotrelatedto any of the parameters studied. In a multivariate stepwise binary logistic regres-sionanalysis(WaldMethod)circulatingendothelialmicroparticlesremainsignificantlyassociatedwithpancreasfatcontentafteradjustingforconfoundingfactors,suchastobacco,diabetesmellitus,hypercholesterolemia,ormetabolicsyndrome.Ourresultsreflectthatinessentialhypertension,pancreasfatcontentissuperiortoliverfattostudybeta-cellfunctionalityandinsulinresistance.Moreover,theauthorsdescribedforthefirsttimethatpancreasfatcontentisrelatedtoendothelialcelldestruction.Furtherstudiesareneededtoconfirmthispoint.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/156709
https://doi.org/10.1111/jch.14600
url https://hdl.handle.net/11441/156709
https://doi.org/10.1111/jch.14600
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical Hypertension, 25 (1), 38-46.
PI13/01917
https://doi.org/10.1111/jch.14600
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Open Access
publisher.none.fl_str_mv Wiley Open Access
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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