Antimutagenic and Antiproliferative Activity of the Coccoloba uvifera L. Extract Loaded in Nanofibers of Gelatin/Agave Fructans Elaborated by Electrospinning

Background: The Coccoloba uvifera L. species is currently considered an important source of compounds of high biological value such as lupeol. This is related to different and important biological activities to human health. Objective: The objective of this study was to encapsulate the C. uvifera ex...

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Autores: Cruz-Salas, Carla N, Prieto López, Cristina, Calderón-Santoyo, Montserrat, Lagarón Cabello, José María, Ramos-Hernández, Jorge A, Ragazzo Sánchez, Juan Arturo
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/298789
Acceso en línea:http://hdl.handle.net/10261/298789
https://api.elsevier.com/content/abstract/scopus_id/85132144526
Access Level:acceso abierto
Palabra clave:Biopolymers
Coccoloba uvifera
Electrospinning
Encapsulation
High grade polymerization agave fructans
Nanofibers
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spelling Antimutagenic and Antiproliferative Activity of the Coccoloba uvifera L. Extract Loaded in Nanofibers of Gelatin/Agave Fructans Elaborated by ElectrospinningCruz-Salas, Carla NPrieto López, CristinaCalderón-Santoyo, MontserratLagarón Cabello, José MaríaRamos-Hernández, Jorge ARagazzo Sánchez, Juan ArturoBiopolymersCoccoloba uviferaElectrospinningEncapsulationHigh grade polymerization agave fructansNanofibersBackground: The Coccoloba uvifera L. species is currently considered an important source of compounds of high biological value such as lupeol. This is related to different and important biological activities to human health. Objective: The objective of this study was to encapsulate the C. uvifera extract in nanofibers made with the biopolymers gelatin (G)/high-grade polymerization agave fructans (HDPAF) in the proportions 1:0, 1:1, 1:2, 1:3 and 0:1, through the electrospinning process, in addition to evaluating the antimutagenic and antiproliferative properties of the encapsulated extract. Methods: The physicochemical characteristics of the nanofibers were evaluated, as well as the antiproliferative and antimutagenic activities of the encapsulated and unencapsulated extract. SEM evaluation shows nanofibers of smooth, continuous morphology and nanometric size (50-250 nm). The TGA, FTIR-ATR, HPLC-MS analyses reveal the presence of the extract in the nanofibers. Results: The extract did not show a mutagenic effect during the development of the Ames test, on the other hand, the MTT test showed the antiproliferative effect at the concentrations of 50 and 100 μg/mL of extract. Conclusion: The extract of C. uvifera loaded in nanofibers elaborated by electrospinning with the G/HDPAF biopolymers conserves its antimutagenic and antiproliferative properties.This study was supported by the Consejo Nacional de Ciencia y Tecnología (CONACyT, Mexico) for the project code 316948, CYTED thematic network code 319RT0576, and Spanish Ministry of Science, Innovation and Universities (project code RTI2018-097249-B-C21).Peer reviewedBentham Science PublishersConsejo Nacional de Ciencia y Tecnología (México)Ministerio de Ciencia e Innovación (España)Programa Iberoamericano de Ciencia y Tecnología para el DesarrolloConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/298789https://api.elsevier.com/content/abstract/scopus_id/85132144526reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097249-B-C21Anti-cancer agents in medicinal chemistryhttps://doi.org/10.2174/1871520622666220316161957Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2987892026-05-22T06:33:51Z
dc.title.none.fl_str_mv Antimutagenic and Antiproliferative Activity of the Coccoloba uvifera L. Extract Loaded in Nanofibers of Gelatin/Agave Fructans Elaborated by Electrospinning
title Antimutagenic and Antiproliferative Activity of the Coccoloba uvifera L. Extract Loaded in Nanofibers of Gelatin/Agave Fructans Elaborated by Electrospinning
spellingShingle Antimutagenic and Antiproliferative Activity of the Coccoloba uvifera L. Extract Loaded in Nanofibers of Gelatin/Agave Fructans Elaborated by Electrospinning
Cruz-Salas, Carla N
Biopolymers
Coccoloba uvifera
Electrospinning
Encapsulation
High grade polymerization agave fructans
Nanofibers
title_short Antimutagenic and Antiproliferative Activity of the Coccoloba uvifera L. Extract Loaded in Nanofibers of Gelatin/Agave Fructans Elaborated by Electrospinning
title_full Antimutagenic and Antiproliferative Activity of the Coccoloba uvifera L. Extract Loaded in Nanofibers of Gelatin/Agave Fructans Elaborated by Electrospinning
title_fullStr Antimutagenic and Antiproliferative Activity of the Coccoloba uvifera L. Extract Loaded in Nanofibers of Gelatin/Agave Fructans Elaborated by Electrospinning
title_full_unstemmed Antimutagenic and Antiproliferative Activity of the Coccoloba uvifera L. Extract Loaded in Nanofibers of Gelatin/Agave Fructans Elaborated by Electrospinning
title_sort Antimutagenic and Antiproliferative Activity of the Coccoloba uvifera L. Extract Loaded in Nanofibers of Gelatin/Agave Fructans Elaborated by Electrospinning
dc.creator.none.fl_str_mv Cruz-Salas, Carla N
Prieto López, Cristina
Calderón-Santoyo, Montserrat
Lagarón Cabello, José María
Ramos-Hernández, Jorge A
Ragazzo Sánchez, Juan Arturo
author Cruz-Salas, Carla N
author_facet Cruz-Salas, Carla N
Prieto López, Cristina
Calderón-Santoyo, Montserrat
Lagarón Cabello, José María
Ramos-Hernández, Jorge A
Ragazzo Sánchez, Juan Arturo
author_role author
author2 Prieto López, Cristina
Calderón-Santoyo, Montserrat
Lagarón Cabello, José María
Ramos-Hernández, Jorge A
Ragazzo Sánchez, Juan Arturo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Nacional de Ciencia y Tecnología (México)
Ministerio de Ciencia e Innovación (España)
Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Biopolymers
Coccoloba uvifera
Electrospinning
Encapsulation
High grade polymerization agave fructans
Nanofibers
topic Biopolymers
Coccoloba uvifera
Electrospinning
Encapsulation
High grade polymerization agave fructans
Nanofibers
description Background: The Coccoloba uvifera L. species is currently considered an important source of compounds of high biological value such as lupeol. This is related to different and important biological activities to human health. Objective: The objective of this study was to encapsulate the C. uvifera extract in nanofibers made with the biopolymers gelatin (G)/high-grade polymerization agave fructans (HDPAF) in the proportions 1:0, 1:1, 1:2, 1:3 and 0:1, through the electrospinning process, in addition to evaluating the antimutagenic and antiproliferative properties of the encapsulated extract. Methods: The physicochemical characteristics of the nanofibers were evaluated, as well as the antiproliferative and antimutagenic activities of the encapsulated and unencapsulated extract. SEM evaluation shows nanofibers of smooth, continuous morphology and nanometric size (50-250 nm). The TGA, FTIR-ATR, HPLC-MS analyses reveal the presence of the extract in the nanofibers. Results: The extract did not show a mutagenic effect during the development of the Ames test, on the other hand, the MTT test showed the antiproliferative effect at the concentrations of 50 and 100 μg/mL of extract. Conclusion: The extract of C. uvifera loaded in nanofibers elaborated by electrospinning with the G/HDPAF biopolymers conserves its antimutagenic and antiproliferative properties.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/298789
https://api.elsevier.com/content/abstract/scopus_id/85132144526
url http://hdl.handle.net/10261/298789
https://api.elsevier.com/content/abstract/scopus_id/85132144526
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-097249-B-C21
Anti-cancer agents in medicinal chemistry
https://doi.org/10.2174/1871520622666220316161957
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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