Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries

Tack, J; Stanghellini, V; Mearin, F; Yiannakou, Y; Layer, P; Coffin, B; Simren, M; Mackinnon, J; Wiseman, G; Marciniak, A; Bouchoucha; Ducrotte; Macaigne; Mion; Schneider; Le Sidanier; Tardy; Zerbib; Andresen; Bischoff; Jander; Jung; Krammer; Langhorst; Omankowsky; Schiefke; Steuer; Van der Voort; Von Arnim; Annese; Cuomo; De Angelis; Di Mario; Di Stefano; Ferrini; Gasbarrini; Giaccobe; Marchi; Marzio; Repici; Savarino; Angos; Berdier; Brotons; Caballero-Plasencia; Clave; Fort; Garcia; Gomez; Martinez; Perello; Rey; Sanchez-Antolin; Serra; Tantina; Toran; Ekesbo; Hellstrom; Kjellstrom; Lindberg; Walter; Arebi; Bridger; Butt; Emmanuel; Eugenicos; Kaushik; Millar; Sanders; Whorwell

Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries

BackgroundIrritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe IBS-C in six European countries (France, Germany, Italy, Spain, Sweden and the UK)...

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Autores:	Tack, J, Stanghellini, V, Mearin, F, Yiannakou, Y, Layer, P, Coffin, B, Simren, M, Mackinnon, J, Wiseman, G, Marciniak, A, Bouchoucha, Ducrotte, Macaigne, Mion, Schneider, Le Sidanier, Tardy, Zerbib, Andresen, Bischoff, Jander, Jung, Krammer, Langhorst, Omankowsky, Schiefke, Steuer, Van der Voort, Von Arnim, Annese, Cuomo, De Angelis, Di Mario, Di Stefano, Ferrini, Gasbarrini, Giaccobe, Marchi, Marzio, Repici, Savarino, Angos, Berdier, Brotons, Caballero-Plasencia, Clave, Fort, Garcia, Gomez, Martinez, Perello, Rey, Sanchez-Antolin, Serra, Tantina, Toran, Ekesbo, Hellstrom, Kjellstrom, Lindberg, Walter, Arebi, Bridger, Butt, Emmanuel, Eugenicos, Kaushik, Millar, Sanders, Whorwell
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2019
País:	España
Institución:	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:	oai:iibsantpau.fundanetsuite.com:p13821
Acceso en línea:	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13821
Access Level:	acceso abierto
Palabra clave:	IBS IBS-C Economic analysis Healthcare resource utilisation Europe

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spelling	Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countriesTack, JStanghellini, VMearin, FYiannakou, YLayer, PCoffin, BSimren, MMackinnon, JWiseman, GMarciniak, ABouchouchaDucrotteMacaigneMionSchneiderLe SidanierTardyZerbibAndresenBischoffJanderJungKrammerLanghorstOmankowskySchiefkeSteuerVan der VoortVon ArnimAnneseCuomoDe AngelisDi MarioDi StefanoFerriniGasbarriniGiaccobeMarchiMarzioRepiciSavarinoAngosBerdierBrotonsCaballero-PlasenciaClaveFortGarciaGomezMartinezPerelloReySanchez-AntolinSerraTantinaToranEkesboHellstromKjellstromLindbergWalterArebiBridgerButtEmmanuelEugenicosKaushikMillarSandersWhorwellIBSIBS-CEconomic analysisHealthcare resource utilisationEuropeBackgroundIrritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe IBS-C in six European countries (France, Germany, Italy, Spain, Sweden and the UK).MethodsAn observational, one year retrospective-prospective (6months each) study of patients diagnosed in the last five years with IBS-C (Rome III criteria) and moderate to severe disease at inclusion (IBS Symptom Severity Scale score175). The primary objective was to assess the direct cost to European healthcare systems.ResultsFive hundred twenty-five patients were included, 60% (range: 43.1-78.8%) suffered from severe IBS-C. During follow-up 11.1-24.0% of patients had a hospitalisation/emergency room (ER) visit, median stay range: 1.5-12.0days and 41.1-90.4% took prescription drugs for IBS-C. 21.4-50.8% of employed patients took sick leave (mean: 11.6-64.1days). The mean annual direct cost to the healthcare systems was Euro937.1- Euro2108.0. The total direct cost (combined costs to healthcare systems and patient) for IBS-C was Euro1421.7-Euro2487.1.ConclusionsIBS-C is not a life-threatening condition; however, it has large impact on healthcare systems and society. Direct and indirect costs for moderate to severe IBS-C were high with the largest direct cost driver being hospitalisations/ER visits.BMC2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13821BMC GASTROENTEROLOGYISSN: 1471230Xreponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p138212026-06-14T12:41:47Z
dc.title.none.fl_str_mv	Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
title	Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
spellingShingle	Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries Tack, J IBS IBS-C Economic analysis Healthcare resource utilisation Europe
title_short	Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
title_full	Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
title_fullStr	Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
title_full_unstemmed	Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
title_sort	Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries
dc.creator.none.fl_str_mv	Tack, J Stanghellini, V Mearin, F Yiannakou, Y Layer, P Coffin, B Simren, M Mackinnon, J Wiseman, G Marciniak, A Bouchoucha Ducrotte Macaigne Mion Schneider Le Sidanier Tardy Zerbib Andresen Bischoff Jander Jung Krammer Langhorst Omankowsky Schiefke Steuer Van der Voort Von Arnim Annese Cuomo De Angelis Di Mario Di Stefano Ferrini Gasbarrini Giaccobe Marchi Marzio Repici Savarino Angos Berdier Brotons Caballero-Plasencia Clave Fort Garcia Gomez Martinez Perello Rey Sanchez-Antolin Serra Tantina Toran Ekesbo Hellstrom Kjellstrom Lindberg Walter Arebi Bridger Butt Emmanuel Eugenicos Kaushik Millar Sanders Whorwell
author	Tack, J
author_facet	Tack, J Stanghellini, V Mearin, F Yiannakou, Y Layer, P Coffin, B Simren, M Mackinnon, J Wiseman, G Marciniak, A Bouchoucha Ducrotte Macaigne Mion Schneider Le Sidanier Tardy Zerbib Andresen Bischoff Jander Jung Krammer Langhorst Omankowsky Schiefke Steuer Van der Voort Von Arnim Annese Cuomo De Angelis Di Mario Di Stefano Ferrini Gasbarrini Giaccobe Marchi Marzio Repici Savarino Angos Berdier Brotons Caballero-Plasencia Clave Fort Garcia Gomez Martinez Perello Rey Sanchez-Antolin Serra Tantina Toran Ekesbo Hellstrom Kjellstrom Lindberg Walter Arebi Bridger Butt Emmanuel Eugenicos Kaushik Millar Sanders Whorwell
author_role	author
author2	Stanghellini, V Mearin, F Yiannakou, Y Layer, P Coffin, B Simren, M Mackinnon, J Wiseman, G Marciniak, A Bouchoucha Ducrotte Macaigne Mion Schneider Le Sidanier Tardy Zerbib Andresen Bischoff Jander Jung Krammer Langhorst Omankowsky Schiefke Steuer Van der Voort Von Arnim Annese Cuomo De Angelis Di Mario Di Stefano Ferrini Gasbarrini Giaccobe Marchi Marzio Repici Savarino Angos Berdier Brotons Caballero-Plasencia Clave Fort Garcia Gomez Martinez Perello Rey Sanchez-Antolin Serra Tantina Toran Ekesbo Hellstrom Kjellstrom Lindberg Walter Arebi Bridger Butt Emmanuel Eugenicos Kaushik Millar Sanders Whorwell
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	IBS IBS-C Economic analysis Healthcare resource utilisation Europe
topic	IBS IBS-C Economic analysis Healthcare resource utilisation Europe
description	BackgroundIrritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe IBS-C in six European countries (France, Germany, Italy, Spain, Sweden and the UK).MethodsAn observational, one year retrospective-prospective (6months each) study of patients diagnosed in the last five years with IBS-C (Rome III criteria) and moderate to severe disease at inclusion (IBS Symptom Severity Scale score175). The primary objective was to assess the direct cost to European healthcare systems.ResultsFive hundred twenty-five patients were included, 60% (range: 43.1-78.8%) suffered from severe IBS-C. During follow-up 11.1-24.0% of patients had a hospitalisation/emergency room (ER) visit, median stay range: 1.5-12.0days and 41.1-90.4% took prescription drugs for IBS-C. 21.4-50.8% of employed patients took sick leave (mean: 11.6-64.1days). The mean annual direct cost to the healthcare systems was Euro937.1- Euro2108.0. The total direct cost (combined costs to healthcare systems and patient) for IBS-C was Euro1421.7-Euro2487.1.ConclusionsIBS-C is not a life-threatening condition; however, it has large impact on healthcare systems and society. Direct and indirect costs for moderate to severe IBS-C were high with the largest direct cost driver being hospitalisations/ER visits.
publishDate	2019
dc.date.none.fl_str_mv	2019
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13821
url	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13821
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	BMC
publisher.none.fl_str_mv	BMC
dc.source.none.fl_str_mv	BMC GASTROENTEROLOGY ISSN: 1471230X reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Economic burden of moderate to severe irritable bowel syndrome with constipation in six European countries

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