In Vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.

Two iridoids, oleuropeoside and ligustroside, and two triterpenoid compounds, oleanolic acid and ursolic acid, ha re been isolated from the leaves of Phillyrea latifolia L. (Oleaceae). These compounds were tested for interactions with the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways of a...

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Autores: Díaz Lanza, Ana María|||0000-0002-4216-3997, Abad, María José, Fernández Matellano, Lidia, Recuero, Cristina, Villaescusa Castillo, Lucinda|||0000-0001-7187-5515, Silván, Ana María, Bermejo, Paulina
Tipo de recurso: artículo
Fecha de publicación:2000
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/64382
Acceso en línea:http://hdl.handle.net/10017/64382
https://dx.doi.org/10.1248/bpb.23.1307
Access Level:acceso abierto
Palabra clave:Phillyrea latifolia
Iridoid
Triterpenoid
PGE(2)
LTC4
TXB2
Farmacia
Pharmacy
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spelling In Vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.Díaz Lanza, Ana María|||0000-0002-4216-3997Abad, María JoséFernández Matellano, LidiaRecuero, CristinaVillaescusa Castillo, Lucinda|||0000-0001-7187-5515Silván, Ana MaríaBermejo, PaulinaPhillyrea latifoliaIridoidTriterpenoidPGE(2)LTC4TXB2FarmaciaPharmacyTwo iridoids, oleuropeoside and ligustroside, and two triterpenoid compounds, oleanolic acid and ursolic acid, ha re been isolated from the leaves of Phillyrea latifolia L. (Oleaceae). These compounds were tested for interactions with the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways of arachidonate metabolism in calcium ionophore-stimulated mouse peritoneal macrophages and human platelets, and for their effect on cell viability Structure-activity relationships obtained for in vitro screening results were discussed, These compounds ale capable of exerting inhibitory actions on enzymes of the arachidonate cascade,,ill compounds assayed showed a significant effect on prostaglandin E-2 (PGE(2))-release, with inhibition percentages similar to the reference drug indomethacin (IC50 = 0.95 muM). The IC50 values of the active compounds ate: oleuropeoside 47 muM, ligustroside 38.53 muM, oleanolic acid 23.51 muM and ursolic acid 60.91 muM;. In the leukotriene C-4 (LTC4)-assay, only oleanolic acid showed a significant effect (IC50 = 16.79 muM). We also investigated the action of compounds on thromborane B-2 (TXB2)-release induced by calcium ionophore in human platelets. Of all the tested compounds, only. ligustroside (IC50 = 122.63 muM) and ursolic acid (IC50 = 50.21 muM) showed a significant effect, although with less potency than the reference drug ibuprofen (IC50 = 1.27 muM). Thus, our compounds possess an array of potentially beneficial anti-inflammatory properties which may, alongside other constituents, contribute to the claimed therapeutic properties of the plant from which they are derived.20002000-10-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/64382https://dx.doi.org/10.1248/bpb.23.1307reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/643822026-06-18T11:13:07Z
dc.title.none.fl_str_mv In Vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.
title In Vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.
spellingShingle In Vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.
Díaz Lanza, Ana María|||0000-0002-4216-3997
Phillyrea latifolia
Iridoid
Triterpenoid
PGE(2)
LTC4
TXB2
Farmacia
Pharmacy
title_short In Vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.
title_full In Vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.
title_fullStr In Vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.
title_full_unstemmed In Vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.
title_sort In Vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.
dc.creator.none.fl_str_mv Díaz Lanza, Ana María|||0000-0002-4216-3997
Abad, María José
Fernández Matellano, Lidia
Recuero, Cristina
Villaescusa Castillo, Lucinda|||0000-0001-7187-5515
Silván, Ana María
Bermejo, Paulina
author Díaz Lanza, Ana María|||0000-0002-4216-3997
author_facet Díaz Lanza, Ana María|||0000-0002-4216-3997
Abad, María José
Fernández Matellano, Lidia
Recuero, Cristina
Villaescusa Castillo, Lucinda|||0000-0001-7187-5515
Silván, Ana María
Bermejo, Paulina
author_role author
author2 Abad, María José
Fernández Matellano, Lidia
Recuero, Cristina
Villaescusa Castillo, Lucinda|||0000-0001-7187-5515
Silván, Ana María
Bermejo, Paulina
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Phillyrea latifolia
Iridoid
Triterpenoid
PGE(2)
LTC4
TXB2
Farmacia
Pharmacy
topic Phillyrea latifolia
Iridoid
Triterpenoid
PGE(2)
LTC4
TXB2
Farmacia
Pharmacy
description Two iridoids, oleuropeoside and ligustroside, and two triterpenoid compounds, oleanolic acid and ursolic acid, ha re been isolated from the leaves of Phillyrea latifolia L. (Oleaceae). These compounds were tested for interactions with the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways of arachidonate metabolism in calcium ionophore-stimulated mouse peritoneal macrophages and human platelets, and for their effect on cell viability Structure-activity relationships obtained for in vitro screening results were discussed, These compounds ale capable of exerting inhibitory actions on enzymes of the arachidonate cascade,,ill compounds assayed showed a significant effect on prostaglandin E-2 (PGE(2))-release, with inhibition percentages similar to the reference drug indomethacin (IC50 = 0.95 muM). The IC50 values of the active compounds ate: oleuropeoside 47 muM, ligustroside 38.53 muM, oleanolic acid 23.51 muM and ursolic acid 60.91 muM;. In the leukotriene C-4 (LTC4)-assay, only oleanolic acid showed a significant effect (IC50 = 16.79 muM). We also investigated the action of compounds on thromborane B-2 (TXB2)-release induced by calcium ionophore in human platelets. Of all the tested compounds, only. ligustroside (IC50 = 122.63 muM) and ursolic acid (IC50 = 50.21 muM) showed a significant effect, although with less potency than the reference drug ibuprofen (IC50 = 1.27 muM). Thus, our compounds possess an array of potentially beneficial anti-inflammatory properties which may, alongside other constituents, contribute to the claimed therapeutic properties of the plant from which they are derived.
publishDate 2000
dc.date.none.fl_str_mv 2000
2000-10-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/64382
https://dx.doi.org/10.1248/bpb.23.1307
url http://hdl.handle.net/10017/64382
https://dx.doi.org/10.1248/bpb.23.1307
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-ShareAlike 4.0 International
http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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