Device-associated multidrug-resistant bacteria surveillance in critically ill children: 10 years of experience

Aim Multidrug-resistant bacterial infections are a public health problem worldwide. However, most of the information available refers to adults. The main objectives were to determine the incidence, risk factors, and outcomes for device-associated infections, especially those involving multidrug-resi...

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Autores: Girona-Alarcón M, Fresán E, Garcia-Garcia A, Bobillo-Perez S, Balaguer M, Felipe A, Esteban ME, Jordan I
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p17728
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17728
Access Level:acceso abierto
Palabra clave:antimicrobial resistance
multidrug-resistant bacteria
nosocomial infection
paediatrics
paediatric intensive care
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spelling Device-associated multidrug-resistant bacteria surveillance in critically ill children: 10 years of experienceGirona-Alarcón MFresán EGarcia-Garcia ABobillo-Perez SBalaguer MFelipe AEsteban MEJordan Iantimicrobial resistancemultidrug-resistant bacterianosocomial infectionpaediatricspaediatric intensive careAim Multidrug-resistant bacterial infections are a public health problem worldwide. However, most of the information available refers to adults. The main objectives were to determine the incidence, risk factors, and outcomes for device-associated infections, especially those involving multidrug-resistant bacteria. Methods This is a prospective, observational study. Children aged >= 1 month and <18 years admitted to the paediatric intensive care unit from 2008 to 2017, with a device-associated infection microbiologically confirmed were included. Patients infected with resistant bacteria were compared with those who had a drug-susceptible infection. Results The study included 213 patients. Out of all the device-associated infections, 22% (48 patients) were caused by multidrug-resistant bacteria. The most frequent were extended-spectrum beta-lactamase (ESBL)-producing enterobacteria. Cardiovascular diseases, age under 1year, comorbidity, prolonged use of invasive device, and length of stay until infection were risk factors for resistant bacteria, but not specifically for ESBL-producing bacteria. Length of stay and mortality was increased in patients with multidrug-resistant bacteria. Conclusion Being under 1-year-old and having a cardiovascular disease were the two major risk factors for resistant bacterial infection. ESBL-producing bacteria were the most frequent multidrug-resistant agents. However, patients with ESBL-producing bacteria did not have any additional risk factors, so they may have been colonised in the community.WILEY2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17728ACTA PAEDIATRICAISSN: 08035253ISSNe: 16512227reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p177282026-05-27T12:37:41Z
dc.title.none.fl_str_mv Device-associated multidrug-resistant bacteria surveillance in critically ill children: 10 years of experience
title Device-associated multidrug-resistant bacteria surveillance in critically ill children: 10 years of experience
spellingShingle Device-associated multidrug-resistant bacteria surveillance in critically ill children: 10 years of experience
Girona-Alarcón M
antimicrobial resistance
multidrug-resistant bacteria
nosocomial infection
paediatrics
paediatric intensive care
title_short Device-associated multidrug-resistant bacteria surveillance in critically ill children: 10 years of experience
title_full Device-associated multidrug-resistant bacteria surveillance in critically ill children: 10 years of experience
title_fullStr Device-associated multidrug-resistant bacteria surveillance in critically ill children: 10 years of experience
title_full_unstemmed Device-associated multidrug-resistant bacteria surveillance in critically ill children: 10 years of experience
title_sort Device-associated multidrug-resistant bacteria surveillance in critically ill children: 10 years of experience
dc.creator.none.fl_str_mv Girona-Alarcón M
Fresán E
Garcia-Garcia A
Bobillo-Perez S
Balaguer M
Felipe A
Esteban ME
Jordan I
author Girona-Alarcón M
author_facet Girona-Alarcón M
Fresán E
Garcia-Garcia A
Bobillo-Perez S
Balaguer M
Felipe A
Esteban ME
Jordan I
author_role author
author2 Fresán E
Garcia-Garcia A
Bobillo-Perez S
Balaguer M
Felipe A
Esteban ME
Jordan I
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv antimicrobial resistance
multidrug-resistant bacteria
nosocomial infection
paediatrics
paediatric intensive care
topic antimicrobial resistance
multidrug-resistant bacteria
nosocomial infection
paediatrics
paediatric intensive care
description Aim Multidrug-resistant bacterial infections are a public health problem worldwide. However, most of the information available refers to adults. The main objectives were to determine the incidence, risk factors, and outcomes for device-associated infections, especially those involving multidrug-resistant bacteria. Methods This is a prospective, observational study. Children aged >= 1 month and <18 years admitted to the paediatric intensive care unit from 2008 to 2017, with a device-associated infection microbiologically confirmed were included. Patients infected with resistant bacteria were compared with those who had a drug-susceptible infection. Results The study included 213 patients. Out of all the device-associated infections, 22% (48 patients) were caused by multidrug-resistant bacteria. The most frequent were extended-spectrum beta-lactamase (ESBL)-producing enterobacteria. Cardiovascular diseases, age under 1year, comorbidity, prolonged use of invasive device, and length of stay until infection were risk factors for resistant bacteria, but not specifically for ESBL-producing bacteria. Length of stay and mortality was increased in patients with multidrug-resistant bacteria. Conclusion Being under 1-year-old and having a cardiovascular disease were the two major risk factors for resistant bacterial infection. ESBL-producing bacteria were the most frequent multidrug-resistant agents. However, patients with ESBL-producing bacteria did not have any additional risk factors, so they may have been colonised in the community.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17728
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17728
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv ACTA PAEDIATRICA
ISSN: 08035253
ISSNe: 16512227
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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