Risk factors for colonisation by Multidrug-Resistant bacteria in critical care units

Introduction Antimicrobial resistance is a major public health challenge recognised by the WHO as an urgent global healthcare concern. Patients in Intensive Care Units (ICUs) are particularly prone to colonisation and/or infection by multidrug-resistant organisms (MDROs). Objectives Delineate the ep...

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Detalles Bibliográficos
Autores: García Parejo, Yolanda, González Rubio, Jesús, García Guerrero, Jesús, Gómez-Juárez Sango, Ana Margarita, Cantero Escribano, José Miguel, Nájera López, Alberto
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/40719
Acceso en línea:https://www.sciencedirect.com/science/article/pii/S0964339724001459?via%3Dihub
https://hdl.handle.net/10578/40719
Access Level:acceso abierto
Palabra clave:Antimicrobial Resistance
Critical Patient Units
Healthcare-Associated Infections
Intensive Care
Multidrug-Resistant Bacteria
Nosocomial Infections
Zero-Resistance Project
Descripción
Sumario:Introduction Antimicrobial resistance is a major public health challenge recognised by the WHO as an urgent global healthcare concern. Patients in Intensive Care Units (ICUs) are particularly prone to colonisation and/or infection by multidrug-resistant organisms (MDROs). Objectives Delineate the epidemiological characteristics and risk factors for MDROs colonisation in mixed ICUs and Resuscitation Units by focusing on initial and nosocomial colonisation.Material and MethodsA descriptive observational study with analytical elements. It uses the Zero-Resistance register from the Preventive Medicine Service of the Albacete General University Hospital (Spain) from April 2016 to December 2021. It identifies the risk factors for MDROs colonisation. Results Of 7,541 cases, 61.0 % with initial colonisation had risk factors for MDROs versus 34.0 % not colonised upon hospitalisation (p < 0.001). Significant risk factors for initial colonisation included hospitalisation for = 5 days within the last 3 months, prior MDROs colonisation/infection and institutionalization. No significant risk factor differences were found for nosocomial colonisation. An association between longer ICU stays and nosocomial colonisation (p < 0.001) was noted. Conclusions Significant risk factors for initial MDROs colonisation were hospitalisation for = 5 days in the last 3 months, prior MDROs colonisation/infection and institutionalisation. Longer ICU stays increased the nosocomial colonisation risk. Implications for Clinical Practice This study underscores the importance to early identify and manage patients at risk for MDROs colonisation in ICUs. By recognising factors (i.e. previous hospitalisations, existing colonisation or infection, impact of prolonged ICU stay), healthcare providers can implement targeted strategies to mitigate the spread of MDROs; e.g. enhanced surveillance, stringent infection control measures and judicious antibiotics use. Our findings highlight the need for a comprehensive approach to manage antimicrobial resistance in critical care settings to ultimately improve patient outcomes and reduce MDROs burden in hospitals.