Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home

This work was supported by the Kids Corona Project, Hospital Sant Joan de Déu, Barcelona, Spain, which received donations from Stavros Niarchos Foundation and Banco de Santander. ISGlobal receives support from the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Och...

Descripción completa

Detalles Bibliográficos
Autores: Rocafort, Muntsa, Henares, Desiree, Brotons de los Reyes, Pedro, Launes, Cristian, de Sevilla, Mariona F, Fumado, Victoria, Barrabeig, Irene, Arias, Sara, Redin, Alba, Ponomarenko, Julia, Melé-Casas, Maria, Millat-Martinez, Pere, Claverol, Joana, Balanza, Nuria, Mira, Alex, Garcia-Garcia, Juan J., Bassat, Quique, Jordan, Iolanda, Muñoz-Almagro, Carmen
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/3414
Acceso en línea:http://hdl.handle.net/20.500.12328/3414
https://dx.doi.org/10.3390/v14071521
Access Level:acceso abierto
Palabra clave:Microbiota nasofaríngia
Nens
Adults
COVID-19
Microbiota nasofaríngea
Niños
Adultos
Nasopharyngeal microbiota
Children
61
id ES_71152b978b2979aa22f0b4ec1bc0692d
oai_identifier_str oai:recercat.cat:20.500.12328/3414
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home
title Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home
spellingShingle Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home
Rocafort, Muntsa
Microbiota nasofaríngia
Nens
Adults
COVID-19
Microbiota nasofaríngea
Niños
Adultos
COVID-19
Nasopharyngeal microbiota
Children
Adults
COVID-19
61
title_short Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home
title_full Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home
title_fullStr Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home
title_full_unstemmed Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home
title_sort Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at home
dc.creator.none.fl_str_mv Rocafort, Muntsa
Henares, Desiree
Brotons de los Reyes, Pedro
Launes, Cristian
de Sevilla, Mariona F
Fumado, Victoria
Barrabeig, Irene
Arias, Sara
Redin, Alba
Ponomarenko, Julia
Melé-Casas, Maria
Millat-Martinez, Pere
Claverol, Joana
Balanza, Nuria
Mira, Alex
Garcia-Garcia, Juan J.
Bassat, Quique
Jordan, Iolanda
Muñoz-Almagro, Carmen
author Rocafort, Muntsa
author_facet Rocafort, Muntsa
Henares, Desiree
Brotons de los Reyes, Pedro
Launes, Cristian
de Sevilla, Mariona F
Fumado, Victoria
Barrabeig, Irene
Arias, Sara
Redin, Alba
Ponomarenko, Julia
Melé-Casas, Maria
Millat-Martinez, Pere
Claverol, Joana
Balanza, Nuria
Mira, Alex
Garcia-Garcia, Juan J.
Bassat, Quique
Jordan, Iolanda
Muñoz-Almagro, Carmen
author_role author
author2 Henares, Desiree
Brotons de los Reyes, Pedro
Launes, Cristian
de Sevilla, Mariona F
Fumado, Victoria
Barrabeig, Irene
Arias, Sara
Redin, Alba
Ponomarenko, Julia
Melé-Casas, Maria
Millat-Martinez, Pere
Claverol, Joana
Balanza, Nuria
Mira, Alex
Garcia-Garcia, Juan J.
Bassat, Quique
Jordan, Iolanda
Muñoz-Almagro, Carmen
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Microbiota nasofaríngia
Nens
Adults
COVID-19
Microbiota nasofaríngea
Niños
Adultos
COVID-19
Nasopharyngeal microbiota
Children
Adults
COVID-19
61
topic Microbiota nasofaríngia
Nens
Adults
COVID-19
Microbiota nasofaríngea
Niños
Adultos
COVID-19
Nasopharyngeal microbiota
Children
Adults
COVID-19
61
description This work was supported by the Kids Corona Project, Hospital Sant Joan de Déu, Barcelona, Spain, which received donations from Stavros Niarchos Foundation and Banco de Santander. ISGlobal receives support from the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa 2019–2023 Program (CEX2018-000806-S). ISGlobal and IRSJD receives support from the Generalitat de Catalunya through the Centres de Recerca de Catalunya Program.Centro de Investigação em Saúde de Manhiça is supported by the government of Mozambique and the Spanish Agency for International Development. CRG is supported by MEIC to the EMBL partnership, Centro de Excelencia Severo Ochoa and CERCA Programme of the Generalitat de Catalunya. DH is supported by a Predoctoral Contract for Training in Research into Health (project number FI17/00248). NB is supported by an FPU predoctoral fellowship from the Spanish Ministry of Universities (FPU18/04260). AM is supported by grants from the Spanish Ministry of Science, (RTI 2018-102032-B-I00) and from the Valencian Innovation Agency (INNVAL20/19/006).
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/3414
https://dx.doi.org/10.3390/v14071521
url http://hdl.handle.net/20.500.12328/3414
https://dx.doi.org/10.3390/v14071521
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Viruses
14;7
https://www.mdpi.com/1999-4915/14/7/1521
info:eu-repo/grantAgreement/ES/MICINN/RTI2018-102032-B-I00
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410627260252160
spelling Impact of COVID-19 lockdown on the nasopharyngeal microbiota of children and adults self-confined at homeRocafort, MuntsaHenares, DesireeBrotons de los Reyes, PedroLaunes, Cristiande Sevilla, Mariona FFumado, VictoriaBarrabeig, IreneArias, SaraRedin, AlbaPonomarenko, JuliaMelé-Casas, MariaMillat-Martinez, PereClaverol, JoanaBalanza, NuriaMira, AlexGarcia-Garcia, Juan J.Bassat, QuiqueJordan, IolandaMuñoz-Almagro, CarmenMicrobiota nasofaríngiaNensAdultsCOVID-19Microbiota nasofaríngeaNiñosAdultosCOVID-19Nasopharyngeal microbiotaChildrenAdultsCOVID-1961This work was supported by the Kids Corona Project, Hospital Sant Joan de Déu, Barcelona, Spain, which received donations from Stavros Niarchos Foundation and Banco de Santander. ISGlobal receives support from the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa 2019–2023 Program (CEX2018-000806-S). ISGlobal and IRSJD receives support from the Generalitat de Catalunya through the Centres de Recerca de Catalunya Program.Centro de Investigação em Saúde de Manhiça is supported by the government of Mozambique and the Spanish Agency for International Development. CRG is supported by MEIC to the EMBL partnership, Centro de Excelencia Severo Ochoa and CERCA Programme of the Generalitat de Catalunya. DH is supported by a Predoctoral Contract for Training in Research into Health (project number FI17/00248). NB is supported by an FPU predoctoral fellowship from the Spanish Ministry of Universities (FPU18/04260). AM is supported by grants from the Spanish Ministry of Science, (RTI 2018-102032-B-I00) and from the Valencian Innovation Agency (INNVAL20/19/006).The increased incidence of COVID-19 cases and deaths in Spain in March 2020 led to the declaration by the Spanish government of a state of emergency imposing strict confinement measures on the population. The objective of this study was to characterize the nasopharyngeal microbiota of children and adults and its relation to SARS-CoV-2 infection and COVID-19 severity during the pandemic lockdown in Spain. This cross-sectional study included family households located in metropolitan Barcelona, Spain, with one adult with a previous confirmed COVID-19 episode and one or more exposed co-habiting child contacts. Nasopharyngeal swabs were used to determine SARS-CoV-2 infection status, characterize the nasopharyngeal microbiota and determine common respiratory DNA/RNA viral co-infections. A total of 173 adult cases and 470 exposed children were included. Overall, a predominance of Corynebacterium and Dolosigranulum and a limited abundance of common pathobionts including Haemophilus and Streptococcus were found both among adults and children. Children with current SARS-CoV-2 infection presented higher bacterial richness and increased Fusobacterium, Streptococcus and Prevotella abundance than non-infected children. Among adults, persistent SARS-CoV-2 RNA was associated with an increased abundance of an unclassified member of the Actinomycetales order. COVID-19 severity was associated with increased Staphylococcus and reduced Dolosigranulum abundance. The stringent COVID-19 lockdown in Spain had a significant impact on the nasopharyngeal microbiota of children, reflected in the limited abundance of common respiratory pathobionts and the predominance of Corynebacterium, regardless of SARS-CoV-2 detection. COVID-19 severity in adults was associated with decreased nasopharynx levels of healthy commensal bacteria.info:eu-repo/semantics/publishedVersionMDPI2022info:eu-repo/semantics/article17http://hdl.handle.net/20.500.12328/3414https://dx.doi.org/10.3390/v14071521reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésViruses14;7https://www.mdpi.com/1999-4915/14/7/1521info:eu-repo/grantAgreement/ES/MICINN/RTI2018-102032-B-I00This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://creativecommons.org/licenses/by/4.0/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/34142026-05-29T05:05:01Z
score 15,811543

Similares en LA Referencia