Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort study
Background: Intralesional methotrexate (MTX-il) has been used as neoadjuvant therapy for keratoacanthoma but has only been utilized in a few isolated cases of cutaneous squamous cell carcinoma as neoadjuvant therapy (cSCC). Objectives: The objective of this study was to evaluate the effectiveness in...
| Autores: | , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/68772 |
| Acesso em linha: | https://hdl.handle.net/10171/68772 |
| Access Level: | acceso abierto |
| Palavra-chave: | Intralesional methotrexate (MTX-il) Neoadjuvant therapy for keratoacanthoma Cutaneous squamous cell carcinoma as neoadjuvant therapy (cSCC) |
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Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort studySalido-Vallejo, R. (Rafael)|||/items/358e939a-9001-4a19-a55d-f8dc95c53c34Cuevas-Asencio, I. (I.)|||/items/1b3e379f-607e-44a8-a9f9-f073622fefddGarnacho-Saucedo, G.M. (Gloria Maria)|||/items/d68294c4-ab9c-42b1-a72c-91d7dfed74aeGonzález-Menchen, A. (Alberto)|||/items/f9024e64-bfa7-4547-8d4a-41352919a633Alcantara-Reifs, C. (C.)|||/items/6623ef92-a43c-4494-98de-4403c9c0152cCorte-Sanchez, S. (S.) de la|||/items/97db73b2-cdb7-4cb4-8072-c8796a510387Vélez, A. (Antonio)|||/items/14e4b784-db1b-4af8-a8d0-29cd1db6034bMoreno-Giménez, J.C. (J. C.)|||/items/e50a1778-e30c-4028-b522-79648a2f7958Intralesional methotrexate (MTX-il)Neoadjuvant therapy for keratoacanthomaCutaneous squamous cell carcinoma as neoadjuvant therapy (cSCC)Background: Intralesional methotrexate (MTX-il) has been used as neoadjuvant therapy for keratoacanthoma but has only been utilized in a few isolated cases of cutaneous squamous cell carcinoma as neoadjuvant therapy (cSCC). Objectives: The objective of this study was to evaluate the effectiveness in clinical practice of presurgical MTX-il infiltration to reduce the size of the cSCC. Safety and the impact on subsequent reconstructive surgical techniques was also assessment. Methods: Single, retrospective, observational study of two historical cohorts differentiated in time. Subjects included were diagnosed with infiltrating cSCC. Patients included in group-A received neoadjuvant MTX-il and patients included in group-B underwent scheduled surgery without prior infiltration. Univariate and multivariate analyses were performed. Results: Group-A patients (n = 43) showed an average reduction in the tumour area of 0.52 cm(2) , while in group-B (n = 43), the area increased by 0.49 cm(2) . A multivariate linear regression analysis demonstrated that MTX-il was the only independent variable that significantly reduced the tumour size [mean 42.6% (95% CI: 31.17-54.03)]. Tumours ≥2 cm in size required significantly a lower percentage of complex reconstructions (P = 0.026). Lower lip tumours showed a higher reduction in group treated with MTX-il (P = 0.045). The only complication observed was discomfort during methotrexate infiltration (60.47%). Conclusions: Neoadjuvant MTX-il reduced the presurgical size of cSCC lesions and could simplify their subsequent surgery.WileyDadun. Depósito Académico Digital Universidad de Navarra20242024-02-0520152015-01-0120152015-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/68772reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/687722026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort study |
| title |
Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort study |
| spellingShingle |
Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort study Salido-Vallejo, R. (Rafael)|||/items/358e939a-9001-4a19-a55d-f8dc95c53c34 Intralesional methotrexate (MTX-il) Neoadjuvant therapy for keratoacanthoma Cutaneous squamous cell carcinoma as neoadjuvant therapy (cSCC) |
| title_short |
Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort study |
| title_full |
Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort study |
| title_fullStr |
Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort study |
| title_full_unstemmed |
Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort study |
| title_sort |
Neoadjuvant intralesional methotrexate in cutaneous squamous cell carcinoma: a comparative cohort study |
| dc.creator.none.fl_str_mv |
Salido-Vallejo, R. (Rafael)|||/items/358e939a-9001-4a19-a55d-f8dc95c53c34 Cuevas-Asencio, I. (I.)|||/items/1b3e379f-607e-44a8-a9f9-f073622fefdd Garnacho-Saucedo, G.M. (Gloria Maria)|||/items/d68294c4-ab9c-42b1-a72c-91d7dfed74ae González-Menchen, A. (Alberto)|||/items/f9024e64-bfa7-4547-8d4a-41352919a633 Alcantara-Reifs, C. (C.)|||/items/6623ef92-a43c-4494-98de-4403c9c0152c Corte-Sanchez, S. (S.) de la|||/items/97db73b2-cdb7-4cb4-8072-c8796a510387 Vélez, A. (Antonio)|||/items/14e4b784-db1b-4af8-a8d0-29cd1db6034b Moreno-Giménez, J.C. (J. C.)|||/items/e50a1778-e30c-4028-b522-79648a2f7958 |
| author |
Salido-Vallejo, R. (Rafael)|||/items/358e939a-9001-4a19-a55d-f8dc95c53c34 |
| author_facet |
Salido-Vallejo, R. (Rafael)|||/items/358e939a-9001-4a19-a55d-f8dc95c53c34 Cuevas-Asencio, I. (I.)|||/items/1b3e379f-607e-44a8-a9f9-f073622fefdd Garnacho-Saucedo, G.M. (Gloria Maria)|||/items/d68294c4-ab9c-42b1-a72c-91d7dfed74ae González-Menchen, A. (Alberto)|||/items/f9024e64-bfa7-4547-8d4a-41352919a633 Alcantara-Reifs, C. (C.)|||/items/6623ef92-a43c-4494-98de-4403c9c0152c Corte-Sanchez, S. (S.) de la|||/items/97db73b2-cdb7-4cb4-8072-c8796a510387 Vélez, A. (Antonio)|||/items/14e4b784-db1b-4af8-a8d0-29cd1db6034b Moreno-Giménez, J.C. (J. C.)|||/items/e50a1778-e30c-4028-b522-79648a2f7958 |
| author_role |
author |
| author2 |
Cuevas-Asencio, I. (I.)|||/items/1b3e379f-607e-44a8-a9f9-f073622fefdd Garnacho-Saucedo, G.M. (Gloria Maria)|||/items/d68294c4-ab9c-42b1-a72c-91d7dfed74ae González-Menchen, A. (Alberto)|||/items/f9024e64-bfa7-4547-8d4a-41352919a633 Alcantara-Reifs, C. (C.)|||/items/6623ef92-a43c-4494-98de-4403c9c0152c Corte-Sanchez, S. (S.) de la|||/items/97db73b2-cdb7-4cb4-8072-c8796a510387 Vélez, A. (Antonio)|||/items/14e4b784-db1b-4af8-a8d0-29cd1db6034b Moreno-Giménez, J.C. (J. C.)|||/items/e50a1778-e30c-4028-b522-79648a2f7958 |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Intralesional methotrexate (MTX-il) Neoadjuvant therapy for keratoacanthoma Cutaneous squamous cell carcinoma as neoadjuvant therapy (cSCC) |
| topic |
Intralesional methotrexate (MTX-il) Neoadjuvant therapy for keratoacanthoma Cutaneous squamous cell carcinoma as neoadjuvant therapy (cSCC) |
| description |
Background: Intralesional methotrexate (MTX-il) has been used as neoadjuvant therapy for keratoacanthoma but has only been utilized in a few isolated cases of cutaneous squamous cell carcinoma as neoadjuvant therapy (cSCC). Objectives: The objective of this study was to evaluate the effectiveness in clinical practice of presurgical MTX-il infiltration to reduce the size of the cSCC. Safety and the impact on subsequent reconstructive surgical techniques was also assessment. Methods: Single, retrospective, observational study of two historical cohorts differentiated in time. Subjects included were diagnosed with infiltrating cSCC. Patients included in group-A received neoadjuvant MTX-il and patients included in group-B underwent scheduled surgery without prior infiltration. Univariate and multivariate analyses were performed. Results: Group-A patients (n = 43) showed an average reduction in the tumour area of 0.52 cm(2) , while in group-B (n = 43), the area increased by 0.49 cm(2) . A multivariate linear regression analysis demonstrated that MTX-il was the only independent variable that significantly reduced the tumour size [mean 42.6% (95% CI: 31.17-54.03)]. Tumours ≥2 cm in size required significantly a lower percentage of complex reconstructions (P = 0.026). Lower lip tumours showed a higher reduction in group treated with MTX-il (P = 0.045). The only complication observed was discomfort during methotrexate infiltration (60.47%). Conclusions: Neoadjuvant MTX-il reduced the presurgical size of cSCC lesions and could simplify their subsequent surgery. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2015-01-01 2015 2015-01-01 2024 2024-02-05 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/68772 |
| url |
https://hdl.handle.net/10171/68772 |
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Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Wiley |
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Wiley |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869410622929633281 |
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15,812455 |