Histological findings after intralesional methotrexate treatment in cutaneous squamous cell carcinoma

Intralesional methotrexate (il-MTX) has been reported as a useful therapy in keratoacanthoma (KA) and cutaneous squamous cell carcinoma (cSCC). However, the data available on the histological changes induced by this therapy are very scarce. We conducted a single center, prospective study that includ...

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Detalles Bibliográficos
Autores: Bergón-Sendín, M. (Marta)|||/items/b696ad1a-2c46-42e1-bd25-0a5cf2d160cb, Parra-Blanco, V. (Verónica)|||/items/ccdb42c9-2c09-4c48-b35d-ed4319da8488, Pulido-Pérez, A. (Ana)|||/items/a2eeb9e8-3841-4590-9773-f49be7058762, Nieto-Benito, L.M. (Lula María)|||/items/c8d8d21e-73ed-4a1a-8f86-83af82a8cf03, Rosell-Díaz, A.M. (Ángel Manuel)|||/items/af597dd8-1fec-41b6-b874-d7bc9ce2f78b, Suárez-Fernández, R. (Ricardo)|||/items/34fbb82c-251f-4ff9-a4f7-969e7c030427
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/68852
Acceso en línea:https://hdl.handle.net/10171/68852
Access Level:acceso abierto
Palabra clave:Intralesional methotrexate
Materias Investigacion::Ciencias de la Salud
Materias Investigacion::Ciencias de la Salud::Dermatología
Cutaneous squamous cell carcinoma (cSCC)
Keratoacanthoma (KA)
Descripción
Sumario:Intralesional methotrexate (il-MTX) has been reported as a useful therapy in keratoacanthoma (KA) and cutaneous squamous cell carcinoma (cSCC). However, the data available on the histological changes induced by this therapy are very scarce. We conducted a single center, prospective study that included 65 cases of cSCC treated with il-MTX before surgical treatment. Two histological studies were conducted in all patients: before intralesional treatment and after surgical removal. Lesions were assessed longitudinally both clinically and histologically. 60 patients (92.3%) responded to il-MTX treatment. There were no differences regarding aggressive histological features of the cSCC between responder and non-responder patients. All cases showed a chronic inflammatory infiltrate after il-MTX. Intratumoral necrosis areas were frequently observed. All cases showed local fibrosis with fine thickening of collagen bundles. Il-MTX induces a chronic lymphohistiocytic inflammatory reaction in both clinical responder and nonresponder patients. Tumor involution after il-MTX is followed by a fine fibrosis that explains the great cosmetic results and improves the accuracy of the follow-up.

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