Anodic Benzylic C(sp3)-H Amination: A Unified Access to Pyrrolidines and Piperidines

An electrochemical aliphatic C-H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C-H amination strategy involves an anodic C-H activation to generate a benzylic cation...

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Detalles Bibliográficos
Autores: Herold, Sebastian, Bafaluy, Daniel, Muñiz, Kilian
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2072/356013
Acceso en línea:http://hdl.handle.net/2072/356013
https://doi.org/10.1039/C8GC01411F
Access Level:acceso abierto
Palabra clave:54
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spelling Anodic Benzylic C(sp3)-H Amination: A Unified Access to Pyrrolidines and PiperidinesHerold, SebastianBafaluy, DanielMuñiz, Kilian54An electrochemical aliphatic C-H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C-H amination strategy involves an anodic C-H activation to generate a benzylic cation, which is efficiently trapped by the nitrogen nucleophile. The applicability of the process is demonstrated for 40 examples comprising both 5- and 6- membered ring formation.2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion3191 p.application/pdfhttp://hdl.handle.net/2072/356013https://doi.org/10.1039/C8GC01411FRECERCAT (Dipòsit de la Recerca de Catalunya)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésL'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2072/3560132026-05-29T05:05:01Z
dc.title.none.fl_str_mv Anodic Benzylic C(sp3)-H Amination: A Unified Access to Pyrrolidines and Piperidines
title Anodic Benzylic C(sp3)-H Amination: A Unified Access to Pyrrolidines and Piperidines
spellingShingle Anodic Benzylic C(sp3)-H Amination: A Unified Access to Pyrrolidines and Piperidines
Herold, Sebastian
54
title_short Anodic Benzylic C(sp3)-H Amination: A Unified Access to Pyrrolidines and Piperidines
title_full Anodic Benzylic C(sp3)-H Amination: A Unified Access to Pyrrolidines and Piperidines
title_fullStr Anodic Benzylic C(sp3)-H Amination: A Unified Access to Pyrrolidines and Piperidines
title_full_unstemmed Anodic Benzylic C(sp3)-H Amination: A Unified Access to Pyrrolidines and Piperidines
title_sort Anodic Benzylic C(sp3)-H Amination: A Unified Access to Pyrrolidines and Piperidines
dc.creator.none.fl_str_mv Herold, Sebastian
Bafaluy, Daniel
Muñiz, Kilian
author Herold, Sebastian
author_facet Herold, Sebastian
Bafaluy, Daniel
Muñiz, Kilian
author_role author
author2 Bafaluy, Daniel
Muñiz, Kilian
author2_role author
author
dc.subject.none.fl_str_mv 54
topic 54
description An electrochemical aliphatic C-H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C-H amination strategy involves an anodic C-H activation to generate a benzylic cation, which is efficiently trapped by the nitrogen nucleophile. The applicability of the process is demonstrated for 40 examples comprising both 5- and 6- membered ring formation.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/2072/356013
https://doi.org/10.1039/C8GC01411F
url http://hdl.handle.net/2072/356013
https://doi.org/10.1039/C8GC01411F
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 3191 p.
application/pdf
dc.source.none.fl_str_mv RECERCAT (Dipòsit de la Recerca de Catalunya)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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