Anodic Benzylic C(sp3)-H Amination: A Unified Access to Pyrrolidines and Piperidines
An electrochemical aliphatic C-H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C-H amination strategy involves an anodic C-H activation to generate a benzylic cation...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2072/356013 |
| Acceso en línea: | http://hdl.handle.net/2072/356013 https://doi.org/10.1039/C8GC01411F |
| Access Level: | acceso abierto |
| Palabra clave: | 54 |
| Sumario: | An electrochemical aliphatic C-H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C-H amination strategy involves an anodic C-H activation to generate a benzylic cation, which is efficiently trapped by the nitrogen nucleophile. The applicability of the process is demonstrated for 40 examples comprising both 5- and 6- membered ring formation. |
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