Systematic review: The gut microbiome and its potential clinical application in inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract. It is well established that the gut microbiome has a profound impact on IBD pathogenesis. Our aim was to systematically review the literature on the IBD gut microbiome and its usefulness...

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Detalhes bibliográficos
Autores: Aldars-García, Laila, Chaparro Sánchez, María, Pérez Gisbert, Francisco Javier
Tipo de documento: artigo
Data de publicação:2021
País:España
Recursos:Universidad Autónoma de Madrid
Repositório:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglês
OAI Identifier:oai:repositorio.uam.es:10486/698160
Acesso em linha:http://hdl.handle.net/10486/698160
https://dx.doi.org/10.3390/microorganisms9050977
Access Level:Acceso aberto
Palavra-chave:Biomarkers
Crohn’s disease
Gutmicrobiome
Inflammatory bowel disease
Ulcerative colitis
Medicina
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spelling Systematic review: The gut microbiome and its potential clinical application in inflammatory bowel diseaseAldars-García, LailaChaparro Sánchez, MaríaPérez Gisbert, Francisco JavierBiomarkersCrohn’s diseaseGutmicrobiomeInflammatory bowel diseaseUlcerative colitisMedicinaInflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract. It is well established that the gut microbiome has a profound impact on IBD pathogenesis. Our aim was to systematically review the literature on the IBD gut microbiome and its usefulness to provide microbiome-based biomarkers. A systematic search of the online bibliographic database PubMed from inception to August 2020 with screening in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted. One-hundred and forty-four papers were eligible for inclusion. There was a wide heterogeneity in microbiome analysis methods or experimental design. The IBD intestinal microbiome was generally characterized by reduced species richness and diversity, and lower temporal stability, while changes in the gut microbiome seemed to play a pivotal role in determining the onset of IBD. Multiple studies have identified certain microbial taxa that are enriched or depleted in IBD, including bacteria, fungi, viruses, and archaea. The two main features in this sense are the decrease in beneficial bacteria and the increase in pathogenic bacteria. Significant differences were also present between remission and relapse IBD status. Shifts in gut microbial community composition and abundance have proven to be valuable as diagnostic biomarkers. The gut microbiome plays a major role in IBD, yet studies need to go from casualty to causality. Longitudinal designs including newly diagnosed treatment-naïve patients are needed to provide insights into the role of microbes in the onset of intestinal inflammation. A better understanding of the human gut microbiome could provide innovative targets for diagnosis, prognosis, treatment and even cure of this relevant disease.This work is supported by Sara Borrell contract CD19/00247 from the Instituto de Salud Carlos III (ISCIII) to L.A.-G.MDPI, Basel, SwitzerlandDepartamento de MedicinaFacultad de MedicinaInstituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)20212021-04-30research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/698160https://dx.doi.org/10.3390/microorganisms9050977reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6981602026-06-23T12:46:27Z
dc.title.none.fl_str_mv Systematic review: The gut microbiome and its potential clinical application in inflammatory bowel disease
title Systematic review: The gut microbiome and its potential clinical application in inflammatory bowel disease
spellingShingle Systematic review: The gut microbiome and its potential clinical application in inflammatory bowel disease
Aldars-García, Laila
Biomarkers
Crohn’s disease
Gutmicrobiome
Inflammatory bowel disease
Ulcerative colitis
Medicina
title_short Systematic review: The gut microbiome and its potential clinical application in inflammatory bowel disease
title_full Systematic review: The gut microbiome and its potential clinical application in inflammatory bowel disease
title_fullStr Systematic review: The gut microbiome and its potential clinical application in inflammatory bowel disease
title_full_unstemmed Systematic review: The gut microbiome and its potential clinical application in inflammatory bowel disease
title_sort Systematic review: The gut microbiome and its potential clinical application in inflammatory bowel disease
dc.creator.none.fl_str_mv Aldars-García, Laila
Chaparro Sánchez, María
Pérez Gisbert, Francisco Javier
author Aldars-García, Laila
author_facet Aldars-García, Laila
Chaparro Sánchez, María
Pérez Gisbert, Francisco Javier
author_role author
author2 Chaparro Sánchez, María
Pérez Gisbert, Francisco Javier
author2_role author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)
dc.subject.none.fl_str_mv Biomarkers
Crohn’s disease
Gutmicrobiome
Inflammatory bowel disease
Ulcerative colitis
Medicina
topic Biomarkers
Crohn’s disease
Gutmicrobiome
Inflammatory bowel disease
Ulcerative colitis
Medicina
description Inflammatory bowel disease (IBD) is a chronic relapsing-remitting systemic disease of the gastrointestinal tract. It is well established that the gut microbiome has a profound impact on IBD pathogenesis. Our aim was to systematically review the literature on the IBD gut microbiome and its usefulness to provide microbiome-based biomarkers. A systematic search of the online bibliographic database PubMed from inception to August 2020 with screening in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted. One-hundred and forty-four papers were eligible for inclusion. There was a wide heterogeneity in microbiome analysis methods or experimental design. The IBD intestinal microbiome was generally characterized by reduced species richness and diversity, and lower temporal stability, while changes in the gut microbiome seemed to play a pivotal role in determining the onset of IBD. Multiple studies have identified certain microbial taxa that are enriched or depleted in IBD, including bacteria, fungi, viruses, and archaea. The two main features in this sense are the decrease in beneficial bacteria and the increase in pathogenic bacteria. Significant differences were also present between remission and relapse IBD status. Shifts in gut microbial community composition and abundance have proven to be valuable as diagnostic biomarkers. The gut microbiome plays a major role in IBD, yet studies need to go from casualty to causality. Longitudinal designs including newly diagnosed treatment-naïve patients are needed to provide insights into the role of microbes in the onset of intestinal inflammation. A better understanding of the human gut microbiome could provide innovative targets for diagnosis, prognosis, treatment and even cure of this relevant disease.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-04-30
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/698160
https://dx.doi.org/10.3390/microorganisms9050977
url http://hdl.handle.net/10486/698160
https://dx.doi.org/10.3390/microorganisms9050977
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI, Basel, Switzerland
publisher.none.fl_str_mv MDPI, Basel, Switzerland
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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