Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry....

ver descrição completa

Detalhes bibliográficos
Autores: Chaparro, M, Garre, A, Ortiz, AN, Palomares, MTDL, Rodriguez, C, Riestra, S, Vela, M, Benitez, JM, Salgado, EF, Rodriguez, ES, Hernandez, V, Ferreiro-Iglesias, R, Diaz, AP, Barrio, J, Huguet, JM, Sicilia, B, Martin-Arranz, MD, Calvet, X, Ginard, D, Alonso-Abreu, I, Fernandez-Salazar, L, Trastoy, PV, Rivero, M, Vera-Mendoza, I, Vega, P, Navarro, P, Sierra, M, Cabriada, JL, Aguas, M, Vicente, R, Navarro-Llavat, M, Echarri, A, Gomollon, F, del Rio, EG, Pinero, C, Casanova, MJ, Spicakova, K, de Zarate, JO, Cortes, ET, Gutierrez, A, Alonso-Galan, H, Hernandez-Martinez, A, Marrero, JM, Poyatos, RL, Calafat, M, Romero, LM, Robledo, P, Bosch, O, Jimenez, N, Comas, ME, Duque, JM, Coronel, AMF, Sampedro, MJ, Abizanda, ES, Martinez, BH, Pozzati, L, Rosaenz, HF, Suarez, BC, Serrano, PL, Lucendo, AJ, Vicente, MM, Bermejo, F, Palanca, JJR, Menacho, M, Carmona, A, Camargo, R, Alsina, ST, Maroto, N, de la Puerta, JN, Castro, E, Marin-Jimenez, I, Botella, B, Sapina, A, Cruz, N, Forcelledo, JLF, Bouhmidi, A, Castano-Milla, C, Opio, V, Nicolas, I, Kutz, M, Bechiarelli, AA, Gordillo, J, Ber, Y, Dominguez, YT, Duran, MTN, Mondejar, SR, Martinez-Cerezo, FJ, Kolle, L, Sabat, M, Ledezma, C, Iyo, E, Roncero, O, Irisarri, R, Lluis, L, Gomez, IB, Zapata, EM, Alcala, MJ, Pascual, CM, Montealegre, M, Mata, L, Monrobel, A, Camba, AH, Hernandez, L, Tejada, M, Mir, A, Galve, ML, Soler, M, Hervias, D, Gomez-Valero, JA, Barreiro-de Acosta, M, Rodriguez-Artalejo, F, Garcia-Esquinas, E, Gisbert, JP
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositório:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p4561
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4561
Access Level:Acceso aberto
Palavra-chave:epidemiology
incidence
inflammatory bowel disease
Crohn's disease
ulcerative colitis
Descrição
Resumo:(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery.

Registros relacionados