Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/139819 |
| Acceso en línea: | https://hdl.handle.net/2445/139819 |
| Access Level: | acceso abierto |
| Palabra clave: | Helicobacteri pilòric Càncer colorectal Helicobacter pylori Colorectal cancer |
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Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in SpainFernández de Larrea Baz, NereaMichel, AngelikaRomero, BeatrizPérez Gómez, BeatrizMoreno Aguado, VíctorMartín Sánchez, VicenteDierssen Sotos, TrinidadJiménez Moleón, José JuanCastilla, JesúsTardón, AdoninaRuiz, IrunePeiró Pérez, RosanaTejada, AntonioChirlaque, María DoloresButt, Julia A.Olmedo Requena, RocíoGómez Acebo, InésLinares, PedroBoldo, ElenaCastells Garangou, AntoniPawlita, MichaelCastaño-Vinyals, GemmaKogevinas, ManolisSanjosé Llongueras, Silvia dePollán, MarinaCampo, Rosa delWaterboer, TimAragonès Sanz, NúriaHelicobacteri pilòricCàncer colorectalHelicobacter pyloriColorectal cancerBackground: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain.Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to >= 4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI).Results: H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cag delta showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women.Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.Frontiers Media2019201920172019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/139819Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fmicb.2017.00888Frontiers in Microbiology, 2017, vol. 8https://doi.org/10.3389/fmicb.2017.00888cc-by (c) Fernández de Larrea Baz, Nerea et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1398192026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain |
| title |
Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain |
| spellingShingle |
Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain Fernández de Larrea Baz, Nerea Helicobacteri pilòric Càncer colorectal Helicobacter pylori Colorectal cancer |
| title_short |
Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain |
| title_full |
Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain |
| title_fullStr |
Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain |
| title_full_unstemmed |
Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain |
| title_sort |
Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain |
| dc.creator.none.fl_str_mv |
Fernández de Larrea Baz, Nerea Michel, Angelika Romero, Beatriz Pérez Gómez, Beatriz Moreno Aguado, Víctor Martín Sánchez, Vicente Dierssen Sotos, Trinidad Jiménez Moleón, José Juan Castilla, Jesús Tardón, Adonina Ruiz, Irune Peiró Pérez, Rosana Tejada, Antonio Chirlaque, María Dolores Butt, Julia A. Olmedo Requena, Rocío Gómez Acebo, Inés Linares, Pedro Boldo, Elena Castells Garangou, Antoni Pawlita, Michael Castaño-Vinyals, Gemma Kogevinas, Manolis Sanjosé Llongueras, Silvia de Pollán, Marina Campo, Rosa del Waterboer, Tim Aragonès Sanz, Núria |
| author |
Fernández de Larrea Baz, Nerea |
| author_facet |
Fernández de Larrea Baz, Nerea Michel, Angelika Romero, Beatriz Pérez Gómez, Beatriz Moreno Aguado, Víctor Martín Sánchez, Vicente Dierssen Sotos, Trinidad Jiménez Moleón, José Juan Castilla, Jesús Tardón, Adonina Ruiz, Irune Peiró Pérez, Rosana Tejada, Antonio Chirlaque, María Dolores Butt, Julia A. Olmedo Requena, Rocío Gómez Acebo, Inés Linares, Pedro Boldo, Elena Castells Garangou, Antoni Pawlita, Michael Castaño-Vinyals, Gemma Kogevinas, Manolis Sanjosé Llongueras, Silvia de Pollán, Marina Campo, Rosa del Waterboer, Tim Aragonès Sanz, Núria |
| author_role |
author |
| author2 |
Michel, Angelika Romero, Beatriz Pérez Gómez, Beatriz Moreno Aguado, Víctor Martín Sánchez, Vicente Dierssen Sotos, Trinidad Jiménez Moleón, José Juan Castilla, Jesús Tardón, Adonina Ruiz, Irune Peiró Pérez, Rosana Tejada, Antonio Chirlaque, María Dolores Butt, Julia A. Olmedo Requena, Rocío Gómez Acebo, Inés Linares, Pedro Boldo, Elena Castells Garangou, Antoni Pawlita, Michael Castaño-Vinyals, Gemma Kogevinas, Manolis Sanjosé Llongueras, Silvia de Pollán, Marina Campo, Rosa del Waterboer, Tim Aragonès Sanz, Núria |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Helicobacteri pilòric Càncer colorectal Helicobacter pylori Colorectal cancer |
| topic |
Helicobacteri pilòric Càncer colorectal Helicobacter pylori Colorectal cancer |
| description |
Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain.Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to >= 4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI).Results: H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cag delta showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women.Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2019 2019 2019 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/2445/139819 |
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https://hdl.handle.net/2445/139819 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.3389/fmicb.2017.00888 Frontiers in Microbiology, 2017, vol. 8 https://doi.org/10.3389/fmicb.2017.00888 |
| dc.rights.none.fl_str_mv |
cc-by (c) Fernández de Larrea Baz, Nerea et al., 2017 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
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cc-by (c) Fernández de Larrea Baz, Nerea et al., 2017 http://creativecommons.org/licenses/by/3.0/es |
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openAccess |
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12 p. application/pdf |
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Frontiers Media |
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Frontiers Media |
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Articles publicats en revistes (Ciències Clíniques) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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