Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain

Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori...

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Detalles Bibliográficos
Autores: Fernández de Larrea Baz, Nerea, Michel, Angelika, Romero, Beatriz, Pérez Gómez, Beatriz, Moreno Aguado, Víctor, Martín Sánchez, Vicente, Dierssen Sotos, Trinidad, Jiménez Moleón, José Juan, Castilla, Jesús, Tardón, Adonina, Ruiz, Irune, Peiró Pérez, Rosana, Tejada, Antonio, Chirlaque, María Dolores, Butt, Julia A., Olmedo Requena, Rocío, Gómez Acebo, Inés, Linares, Pedro, Boldo, Elena, Castells Garangou, Antoni, Pawlita, Michael, Castaño-Vinyals, Gemma, Kogevinas, Manolis, Sanjosé Llongueras, Silvia de, Pollán, Marina, Campo, Rosa del, Waterboer, Tim, Aragonès Sanz, Núria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/139819
Acceso en línea:https://hdl.handle.net/2445/139819
Access Level:acceso abierto
Palabra clave:Helicobacteri pilòric
Càncer colorectal
Helicobacter pylori
Colorectal cancer
Descripción
Sumario:Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain.Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to >= 4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI).Results: H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cag delta showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women.Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.

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