TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery

BACKGROUND: In many immune-related diseases, inflammatory responses and several clinical outcomes are related to increased NF-κB activity. We aimed to evaluate whether SNPs related to the NF-κB signaling pathway are associated with higher susceptibility to infection, septic shock, and septic-shock-r...

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Autores: Jimenez-Sousa, Maria Angeles, Fadrique, Alejandra, Liu, Pilar, Fernandez-Rodriguez, Amanda, Lorenzo-López, Mario, Gómez-Sánchez, Esther, Gomez-Sanz, Alicia, Heredia-Rodríguez, María, Gómez-Pesquera, Estefanía, Martinez, Isidoro, Tamayo, Eduardo, Resino, Salvador
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/8895
Acceso en línea:http://hdl.handle.net/20.500.12105/8895
Access Level:acceso abierto
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spelling TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major SurgeryJimenez-Sousa, Maria AngelesFadrique, AlejandraLiu, PilarFernandez-Rodriguez, AmandaLorenzo-López, MarioGómez-Sánchez, EstherGomez-Sanz, AliciaHeredia-Rodríguez, MaríaGómez-Pesquera, EstefaníaMartinez, IsidoroTamayo, EduardoResino, SalvadorBACKGROUND: In many immune-related diseases, inflammatory responses and several clinical outcomes are related to increased NF-κB activity. We aimed to evaluate whether SNPs related to the NF-κB signaling pathway are associated with higher susceptibility to infection, septic shock, and septic-shock-related death in European patients who underwent major surgery. METHODS: We performed a case-control study on 184 patients with septic shock and 212 with systemic inflammatory response syndrome, and a longitudinal substudy on septic shock patients. Thirty-three SNPs within genes belonging to or regulating the NF-κB signaling pathway were genotyped by Agena Bioscience's MassARRAY platform. RESULTS: No significant results were found for susceptibility to infection and septic shock in the multivariate analysis after adjusting for multiple comparisons. Regarding septic-shock-related death, patients with TNFAIP3 rs6920220 AA, TNIP1 rs73272842 AA, TNIP1 rs3792783 GG, and TNIP1 rs7708392 CC genotypes had the highest risk of septic-shock-related death in the first 28 and 90 days. Also, the MyD88 rs7744 GG genotype was associated with a higher risk of death during the first 90 days. Haplotype analysis shows us that patients with the TNIP1 GAG haplotype (composed of rs73272842, rs3792783, and rs7708392) had a lower risk of death in the first 28 days and the TNIP1 AGC haplotype was associated with a higher risk of death in the first 90 days. CONCLUSIONS: The SNPs in the genes TNFAIP3, TNIP1, and MyD88 were linked to the risk of septic-shock-related death in patients who underwent major surgery.Multidisciplinary Digital Publishing Institute (MDPI)Instituto de Salud Carlos IIIJunta de Castilla y León (España)20202020-01-1520192019-02-2620192019-02-26journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/8895reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PI15 01451ES GRS 463 AES 773 AES CT25-ESP01-01 Not availableES CP14CIII 00010open accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/88952026-06-12T12:43:37Z
dc.title.none.fl_str_mv TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery
title TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery
spellingShingle TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery
Jimenez-Sousa, Maria Angeles
title_short TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery
title_full TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery
title_fullStr TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery
title_full_unstemmed TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery
title_sort TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery
dc.creator.none.fl_str_mv Jimenez-Sousa, Maria Angeles
Fadrique, Alejandra
Liu, Pilar
Fernandez-Rodriguez, Amanda
Lorenzo-López, Mario
Gómez-Sánchez, Esther
Gomez-Sanz, Alicia
Heredia-Rodríguez, María
Gómez-Pesquera, Estefanía
Martinez, Isidoro
Tamayo, Eduardo
Resino, Salvador
author Jimenez-Sousa, Maria Angeles
author_facet Jimenez-Sousa, Maria Angeles
Fadrique, Alejandra
Liu, Pilar
Fernandez-Rodriguez, Amanda
Lorenzo-López, Mario
Gómez-Sánchez, Esther
Gomez-Sanz, Alicia
Heredia-Rodríguez, María
Gómez-Pesquera, Estefanía
Martinez, Isidoro
Tamayo, Eduardo
Resino, Salvador
author_role author
author2 Fadrique, Alejandra
Liu, Pilar
Fernandez-Rodriguez, Amanda
Lorenzo-López, Mario
Gómez-Sánchez, Esther
Gomez-Sanz, Alicia
Heredia-Rodríguez, María
Gómez-Pesquera, Estefanía
Martinez, Isidoro
Tamayo, Eduardo
Resino, Salvador
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Junta de Castilla y León (España)
description BACKGROUND: In many immune-related diseases, inflammatory responses and several clinical outcomes are related to increased NF-κB activity. We aimed to evaluate whether SNPs related to the NF-κB signaling pathway are associated with higher susceptibility to infection, septic shock, and septic-shock-related death in European patients who underwent major surgery. METHODS: We performed a case-control study on 184 patients with septic shock and 212 with systemic inflammatory response syndrome, and a longitudinal substudy on septic shock patients. Thirty-three SNPs within genes belonging to or regulating the NF-κB signaling pathway were genotyped by Agena Bioscience's MassARRAY platform. RESULTS: No significant results were found for susceptibility to infection and septic shock in the multivariate analysis after adjusting for multiple comparisons. Regarding septic-shock-related death, patients with TNFAIP3 rs6920220 AA, TNIP1 rs73272842 AA, TNIP1 rs3792783 GG, and TNIP1 rs7708392 CC genotypes had the highest risk of septic-shock-related death in the first 28 and 90 days. Also, the MyD88 rs7744 GG genotype was associated with a higher risk of death during the first 90 days. Haplotype analysis shows us that patients with the TNIP1 GAG haplotype (composed of rs73272842, rs3792783, and rs7708392) had a lower risk of death in the first 28 days and the TNIP1 AGC haplotype was associated with a higher risk of death in the first 90 days. CONCLUSIONS: The SNPs in the genes TNFAIP3, TNIP1, and MyD88 were linked to the risk of septic-shock-related death in patients who underwent major surgery.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-02-26
2019
2019-02-26
2020
2020-01-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/8895
url http://hdl.handle.net/20.500.12105/8895
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ES PI15 01451
ES GRS 463 A
ES 773 A
ES CT25-ESP01-01 Not available
ES CP14CIII 00010
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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