Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study

The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnos...

Descripción completa

Detalles Bibliográficos
Autores: Jimenez-Sousa, Maria Angeles, Liu, Pilar, Medrano, Luz Maria, Fernandez-Rodriguez, Amanda, Almansa, Raquel, Gómez-Sánchez, Esther, Rico, Lucía, Lorenzo, Mario, Fadrique, Alejandra, Tamayo, Eduardo, Resino, Salvador
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/9153
Acceso en línea:http://hdl.handle.net/20.500.12105/9153
Access Level:acceso abierto
Palabra clave:Aged
Alleles
Cardiac Surgical Procedures
Case-Control Studies
European Continental Ancestry Group
Female
Gene Frequency
Genotype
Humans
Lipopolysaccharide Receptors
Male
Middle Aged
Polymorphism, Single Nucleotide
Retrospective Studies
Risk Factors
Sepsis
Shock, Septic
Descripción
Sumario:The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnosis was established by international consensus definitions. The outcome variable was the death within 28, 60 and 90 days after septic shock diagnosis. The CD14 rs2569190 polymorphism was analyzed by Agena Bioscience's MassARRAY platform. For the genetic association analysis with survival was selected a recessive inheritance model (GG vs. AA/AG). One hundred thirteen out of 205 patients (55.1%) died with a survival median of 39 days (95%CI = 30.6; 47.4). Patients with rs2569190 GG genotype had shorter survival probability than rs2569190 AA/AG genotype at 60 days (62.3% vs 50%; p = 0.035), and 90 days (62.3% vs 52.6%; p = 0.046). The rs2569190 GG genotype was associated with increased risk of septic shock-related death in the first 60 days (adjusted hazard ratio (aHR) = 1.67; p = 0.016) and 90 days (aHR = 1.64; p = 0.020) compared to rs2569190 AA/AG genotype. In conclusion, the presence of CD14 rs2569190 GG genotype was associated with death in shock septic patients who underwent major surgery. Further studies with bigger sample size are required to verify this relationship.

Similares en LA Referencia