NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls

Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls (NCC) in the ana...

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Detalles Bibliográficos
Autores: Krotka, Pavla, Hees, Katharina, Jacko, Peter, Magirr, Dominic, Posch, Martin, Bofill Roig, Marta|||0000-0002-4400-7541
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/415926
Acceso en línea:https://hdl.handle.net/2117/415926
https://dx.doi.org/10.1016/j.softx.2023.101437
Access Level:acceso abierto
Palabra clave:Statistics
Clinical trial simulation
Platform trials
Shared controls
Non-concurrent controls
Àrees temàtiques de la UPC::Economia i organització d'empreses
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repository_id_str
spelling NCC: An R-package for analysis and simulation of platform trials with non-concurrent controlsKrotka, PavlaHees, KatharinaJacko, PeterMagirr, DominicPosch, MartinBofill Roig, Marta|||0000-0002-4400-7541StatisticsClinical trial simulationPlatform trialsShared controlsNon-concurrent controlsÀrees temàtiques de la UPC::Economia i organització d'empresesPlatform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls (NCC) in the analysis. We present the R-package NCC for the design and analysis of platform trials using non-concurrent controls. NCC allows for simulating platform trials and evaluating the properties of analysis methods that make use of non-concurrent controls in a variety of settings. We describe the main NCC functions and show how to use the package to simulate and analyse platform trials by means of specific examples.Peer Reviewed20232023-07-0120242024-10-15journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/415926https://dx.doi.org/10.1016/j.softx.2023.101437reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4159262026-05-27T15:37:01Z
dc.title.none.fl_str_mv NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
title NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
spellingShingle NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
Krotka, Pavla
Statistics
Clinical trial simulation
Platform trials
Shared controls
Non-concurrent controls
Àrees temàtiques de la UPC::Economia i organització d'empreses
title_short NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
title_full NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
title_fullStr NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
title_full_unstemmed NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
title_sort NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
dc.creator.none.fl_str_mv Krotka, Pavla
Hees, Katharina
Jacko, Peter
Magirr, Dominic
Posch, Martin
Bofill Roig, Marta|||0000-0002-4400-7541
author Krotka, Pavla
author_facet Krotka, Pavla
Hees, Katharina
Jacko, Peter
Magirr, Dominic
Posch, Martin
Bofill Roig, Marta|||0000-0002-4400-7541
author_role author
author2 Hees, Katharina
Jacko, Peter
Magirr, Dominic
Posch, Martin
Bofill Roig, Marta|||0000-0002-4400-7541
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Statistics
Clinical trial simulation
Platform trials
Shared controls
Non-concurrent controls
Àrees temàtiques de la UPC::Economia i organització d'empreses
topic Statistics
Clinical trial simulation
Platform trials
Shared controls
Non-concurrent controls
Àrees temàtiques de la UPC::Economia i organització d'empreses
description Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in such trials can be improved by utilizing non-concurrent controls (NCC) in the analysis. We present the R-package NCC for the design and analysis of platform trials using non-concurrent controls. NCC allows for simulating platform trials and evaluating the properties of analysis methods that make use of non-concurrent controls in a variety of settings. We describe the main NCC functions and show how to use the package to simulate and analyse platform trials by means of specific examples.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-07-01
2024
2024-10-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/415926
https://dx.doi.org/10.1016/j.softx.2023.101437
url https://hdl.handle.net/2117/415926
https://dx.doi.org/10.1016/j.softx.2023.101437
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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