Increased mortality after kidney transplantation in mildly frail recipients
Background: physical Frailty Phenotype (PFP) is the most used frailty instrument among kidney transplant recipients, classifying patients as pre-frail if they have 1-2 criteria and as frail if they have ≥3. However, different definitions of robustness have been used among renal patients, including o...
| Autores: | , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/56036 |
| Acceso en línea: | http://hdl.handle.net/10230/56036 http://dx.doi.org/10.1093/ckj/sfac159 |
| Access Level: | acceso abierto |
| Palabra clave: | Fried Frailty phenotype Survival Ttransplant |
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Increased mortality after kidney transplantation in mildly frail recipientsPérez-Sáez, María JoséArias Cabrales, Carlos EnriqueRedondo Pachón, María DoloresBurballa Tàrrega, Carla, 1988-Buxeda, AnnaBach Pascual, AnnaFaura, AnnaJunyent-Iglesias, ErnestinaMarco Navarro, EsterRodríguez-Mañas, LeocadioCrespo Barrio, MartaPascual Santos, JulioFRAIL-MAR Study GroupFriedFrailty phenotypeSurvivalTtransplantBackground: physical Frailty Phenotype (PFP) is the most used frailty instrument among kidney transplant recipients, classifying patients as pre-frail if they have 1-2 criteria and as frail if they have ≥3. However, different definitions of robustness have been used among renal patients, including only those who have 0 criteria, or those with 0-1 criteria. Our aim was to determine the impact of one PFP criterion on transplant outcomes. Methods: we undertook a retrospective study of 296 kidney transplant recipients who had been evaluated for frailty by PFP at the time of evaluating for transplantation. Results: only 30.4% of patients had 0 criteria, and an additional 42.9% showed one PFP criterion. As PFP score increased, a higher percentage of women and cerebrovascular disease were found. Recipients with 0-1 criteria had lower 1-year mortality after transplant than those with ≥2 (1.8% vs 10.1%), but this difference was already present when we only considered those who scored 0 (mortality 1.1%) and 1 (mortality 2.4%) separately. The multivariable analysis confirmed that one PFP criterion was associated to a higher risk of patient death after kidney transplantation [hazard ratio 3.52 (95% confidence interval 1.03-15.9)]. Conclusions: listed kidney transplant candidates frequently show only one PFP frailty criterion. This has an independent impact on patient survival after transplantation.Oxford University Press202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/56036http://dx.doi.org/10.1093/ckj/sfac159reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCopyright © Pérez-Sáez MJ, Arias-Cabrales CE, Redondo-Pachón D, Burballa C, Buxeda A, Bach A, et al. 2022. Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact moc.puo@snoissimrep.slanruojhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/560362026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Increased mortality after kidney transplantation in mildly frail recipients |
| title |
Increased mortality after kidney transplantation in mildly frail recipients |
| spellingShingle |
Increased mortality after kidney transplantation in mildly frail recipients Pérez-Sáez, María José Fried Frailty phenotype Survival Ttransplant |
| title_short |
Increased mortality after kidney transplantation in mildly frail recipients |
| title_full |
Increased mortality after kidney transplantation in mildly frail recipients |
| title_fullStr |
Increased mortality after kidney transplantation in mildly frail recipients |
| title_full_unstemmed |
Increased mortality after kidney transplantation in mildly frail recipients |
| title_sort |
Increased mortality after kidney transplantation in mildly frail recipients |
| dc.creator.none.fl_str_mv |
Pérez-Sáez, María José Arias Cabrales, Carlos Enrique Redondo Pachón, María Dolores Burballa Tàrrega, Carla, 1988- Buxeda, Anna Bach Pascual, Anna Faura, Anna Junyent-Iglesias, Ernestina Marco Navarro, Ester Rodríguez-Mañas, Leocadio Crespo Barrio, Marta Pascual Santos, Julio FRAIL-MAR Study Group |
| author |
Pérez-Sáez, María José |
| author_facet |
Pérez-Sáez, María José Arias Cabrales, Carlos Enrique Redondo Pachón, María Dolores Burballa Tàrrega, Carla, 1988- Buxeda, Anna Bach Pascual, Anna Faura, Anna Junyent-Iglesias, Ernestina Marco Navarro, Ester Rodríguez-Mañas, Leocadio Crespo Barrio, Marta Pascual Santos, Julio FRAIL-MAR Study Group |
| author_role |
author |
| author2 |
Arias Cabrales, Carlos Enrique Redondo Pachón, María Dolores Burballa Tàrrega, Carla, 1988- Buxeda, Anna Bach Pascual, Anna Faura, Anna Junyent-Iglesias, Ernestina Marco Navarro, Ester Rodríguez-Mañas, Leocadio Crespo Barrio, Marta Pascual Santos, Julio FRAIL-MAR Study Group |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Fried Frailty phenotype Survival Ttransplant |
| topic |
Fried Frailty phenotype Survival Ttransplant |
| description |
Background: physical Frailty Phenotype (PFP) is the most used frailty instrument among kidney transplant recipients, classifying patients as pre-frail if they have 1-2 criteria and as frail if they have ≥3. However, different definitions of robustness have been used among renal patients, including only those who have 0 criteria, or those with 0-1 criteria. Our aim was to determine the impact of one PFP criterion on transplant outcomes. Methods: we undertook a retrospective study of 296 kidney transplant recipients who had been evaluated for frailty by PFP at the time of evaluating for transplantation. Results: only 30.4% of patients had 0 criteria, and an additional 42.9% showed one PFP criterion. As PFP score increased, a higher percentage of women and cerebrovascular disease were found. Recipients with 0-1 criteria had lower 1-year mortality after transplant than those with ≥2 (1.8% vs 10.1%), but this difference was already present when we only considered those who scored 0 (mortality 1.1%) and 1 (mortality 2.4%) separately. The multivariable analysis confirmed that one PFP criterion was associated to a higher risk of patient death after kidney transplantation [hazard ratio 3.52 (95% confidence interval 1.03-15.9)]. Conclusions: listed kidney transplant candidates frequently show only one PFP frailty criterion. This has an independent impact on patient survival after transplantation. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2023 2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/56036 http://dx.doi.org/10.1093/ckj/sfac159 |
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http://hdl.handle.net/10230/56036 http://dx.doi.org/10.1093/ckj/sfac159 |
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Inglés |
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Inglés |
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http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Oxford University Press |
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Oxford University Press |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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