Long-Term Impact of COVID-19 on Disorders of Gut-Brain Interaction: Incidence, Symptom Burden, and Psychological Comorbidities

Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the potential exacerbation of gastrointestinal symptoms in patients with disorders of gut-brain interaction (DGBIs). However, the distinct symptom trajectories and psychological burden in patients wi...

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Detalhes bibliográficos
Autores: Marasco, G, Hod, K, Colecchia, L, Cremon, C, Barbaro, MR, Cacciari, G, Falangone, F, Kagramanova, A, Bordin, D, Drug, V, Miftode, E, Fusaroli, P, Mohamed, SY, Ricci, C, Bellini, M, Rahman, MM, Melcarne, L, Santos, J, Lobo, B, Bor, S, Yapali, S, Akyol, D, Sapmaz, FP, Urun, YY, Eskazan, T, Celebi, A, Kacmaz, H, Ebik, B, Binicier, HC, Bugdayci, MS, Yagci, MB, Pullukcu, H, Kaya, BY, Tureyen, A, Hatemi, I, Koc, ES, Sirin, G, Caliskan, AR, Bengi, G, Alis, EE, Lukic, S, Trajkovska, M, Dumitrascu, D, Pietrangelo, A, Corradini, E, Simren, M, Sjolund, J, Tornkvist, N, Ghoshal, UC, Kolokolnikova, O, Colecchia, A, Serra, J, Maconi, G, De Giorgio, R, Danese, S, Portincasa, P, Di Sabatino, A, Maggio, M, Philippou, E, Lee, YY, Salvi, D, Venturi, A, Borghi, C, Zoli, M, Gionchetti, P, Viale, P, Stanghellini, V, Barbara, G
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p6331
Acesso em linha:https://i3pt.portalinvestigacion.com/publicaciones/6331
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105000887430&doi=10.1002%2Fueg2.70005&partnerID=40&md5=f4367813cfbeb7e79c36e60abe3aefd6
Access Level:acceso abierto
Palavra-chave:anxiety
COVID-19
depression
disorders of gut-brain interaction
functional dyspepsia
gastrointestinal symptoms
irritable bowel syndrome
post-infection gastrointestinal disorders
Descrição
Resumo:Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the potential exacerbation of gastrointestinal symptoms in patients with disorders of gut-brain interaction (DGBIs). However, the distinct symptom trajectories and psychological burden in patients with post-COVID-19 DGBIs compared with patients with pre-existing irritable bowel syndrome (IBS)/functional dyspepsia (FD) and non-DGBI controls remain poorly understood. Objectives To examine the long-term gastrointestinal symptom progression and psychological comorbidities in patients with post-COVID-19 DGBI, patients with pre-existing IBS/FD and non-DGBI controls. Methods This post hoc analysis of a prospective multicenter cohort study reviewed patient charts for demographic data and medical history. Participants completed the Gastrointestinal Symptom Rating Scale at four time points: baseline, 1, 6, and 12 months, and the Hospital Anxiety and Depression Scale at 6 and 12 months. The cohort was divided into three groups: (1) post-COVID-19 DGBIs (2) non-DGBI, and (3) pre-existing IBS/FD, with the post-COVID-19 DGBIs group compared to the latter two control groups. Results Among 599 eligible patients, 27 (4.5%) were identified as post-COVID-19 DGBI. This group experienced worsening abdominal pain, hunger pain, heartburn, and acid regurgitation, unlike symptom improvement or stability in non-DGBI controls (p < 0.001 for all symptoms, except hunger pain, p = 0.001). While patients with pre-existing IBS/FD improved in most gastrointestinal symptoms but worsened in constipation and incomplete evacuation, patients with post-COVID-19 DGBI exhibited consistent symptom deterioration across multiple gastrointestinal domains. Anxiety and depression remained unchanged in patients with post-COVID-19 DGBI, contrasting with significant reductions in controls (non-DGBI: p = 0.003 and p = 0.057; pre-existing IBS/FD: p = 0.019 and p = 0.007, respectively). Conclusions COVID-19 infection is associated with the development of newly diagnosed DGBIs and distinct symptom trajectories when compared with patients with pre-existing IBS/FD. Patients with post-COVID-19 DGBI experience progressive gastrointestinal symptom deterioration and persistent psychological distress, underscoring the need for tailored management strategies for this unique subgroup.

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