Tryptase: genetic and functional considerations.
[EN] Tryptase is one of the main proteases located in the secretory granules of the mast cells, and is released through degranulation. It is therefore assumed to play an important role in inflammatory and allergic processes. Four genes are known to encode for these enzymes, with different alleles th...
| Autores: | , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2012 |
| País: | España |
| Recursos: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/158971 |
| Acesso em linha: | http://hdl.handle.net/10366/158971 |
| Access Level: | acceso abierto |
| Palavra-chave: | Tryptase SNP Mast cells Inflammation Genetic Predisposition to Disease Tryptases Mutation Inflammation Mediators Genetics Hypersensitivity Animals Mast Cells Humans Immunity Cell Degranulation Allergy and Immunology 3207.01 Alergias 2409 Genética hipersensibilidad alergia e inmunología animales humanos mastocitos triptasas mediadores de la inflamación mutación inmunidad desgranulación celular genética predisposición genética a la enfermedad |
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oai:gredos.usal.es:10366/158971 |
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Tryptase: genetic and functional considerations.Hernández Hernández, LauraSanz Lozano, Catalina SofíaGarcía Solaesa, VirginiaPadrón, JGarcía Sánchez, María AsunciónDávila González, Ignacio JesúsIsidoro García, MaríaLorente Toledano, FélixTryptaseSNPMast cellsInflammationGenetic Predisposition to DiseaseTryptasesMutationInflammation MediatorsGeneticsHypersensitivityAnimalsMast CellsHumansImmunityCell DegranulationAllergy and Immunology3207.01 Alergias2409 Genéticahipersensibilidadalergia e inmunologíaanimaleshumanosmastocitostriptasasmediadores de la inflamaciónmutacióninmunidaddesgranulación celulargenéticapredisposición genética a la enfermedad[EN] Tryptase is one of the main proteases located in the secretory granules of the mast cells, and is released through degranulation. It is therefore assumed to play an important role in inflammatory and allergic processes. Four genes are known to encode for these enzymes, with different alleles that give rise to different types of tryptases. The term "tryptase" generally refers to β-tryptase, which in vivo is a heterotetramer, possessing a structure of vital importance for enabling drug and substrate access to the active site of the molecule. Tryptase has been reported to possess antagonistic functions, since it plays an important role both in inflammatory phenomena and as a protector against infection. In allergic processes it is associated to bronchial hyperresponsiveness in asthmatic patients, where PAR-2 is of great importance as an airway receptor. Lastly, the genes that encode for tryptase are highly polymorphic and complex. As a result, it is important to establish a relationship between genotype and phenotype in disorders such as asthma, and to identify mutations that are presumably of pharmacological relevance.Elservier202420242012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/158971reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1589712026-06-07T06:28:51Z |
| dc.title.none.fl_str_mv |
Tryptase: genetic and functional considerations. |
| title |
Tryptase: genetic and functional considerations. |
| spellingShingle |
Tryptase: genetic and functional considerations. Hernández Hernández, Laura Tryptase SNP Mast cells Inflammation Genetic Predisposition to Disease Tryptases Mutation Inflammation Mediators Genetics Hypersensitivity Animals Mast Cells Humans Immunity Cell Degranulation Allergy and Immunology 3207.01 Alergias 2409 Genética hipersensibilidad alergia e inmunología animales humanos mastocitos triptasas mediadores de la inflamación mutación inmunidad desgranulación celular genética predisposición genética a la enfermedad |
| title_short |
Tryptase: genetic and functional considerations. |
| title_full |
Tryptase: genetic and functional considerations. |
| title_fullStr |
Tryptase: genetic and functional considerations. |
| title_full_unstemmed |
Tryptase: genetic and functional considerations. |
| title_sort |
Tryptase: genetic and functional considerations. |
| dc.creator.none.fl_str_mv |
Hernández Hernández, Laura Sanz Lozano, Catalina Sofía García Solaesa, Virginia Padrón, J García Sánchez, María Asunción Dávila González, Ignacio Jesús Isidoro García, María Lorente Toledano, Félix |
| author |
Hernández Hernández, Laura |
| author_facet |
Hernández Hernández, Laura Sanz Lozano, Catalina Sofía García Solaesa, Virginia Padrón, J García Sánchez, María Asunción Dávila González, Ignacio Jesús Isidoro García, María Lorente Toledano, Félix |
| author_role |
author |
| author2 |
Sanz Lozano, Catalina Sofía García Solaesa, Virginia Padrón, J García Sánchez, María Asunción Dávila González, Ignacio Jesús Isidoro García, María Lorente Toledano, Félix |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Tryptase SNP Mast cells Inflammation Genetic Predisposition to Disease Tryptases Mutation Inflammation Mediators Genetics Hypersensitivity Animals Mast Cells Humans Immunity Cell Degranulation Allergy and Immunology 3207.01 Alergias 2409 Genética hipersensibilidad alergia e inmunología animales humanos mastocitos triptasas mediadores de la inflamación mutación inmunidad desgranulación celular genética predisposición genética a la enfermedad |
| topic |
Tryptase SNP Mast cells Inflammation Genetic Predisposition to Disease Tryptases Mutation Inflammation Mediators Genetics Hypersensitivity Animals Mast Cells Humans Immunity Cell Degranulation Allergy and Immunology 3207.01 Alergias 2409 Genética hipersensibilidad alergia e inmunología animales humanos mastocitos triptasas mediadores de la inflamación mutación inmunidad desgranulación celular genética predisposición genética a la enfermedad |
| description |
[EN] Tryptase is one of the main proteases located in the secretory granules of the mast cells, and is released through degranulation. It is therefore assumed to play an important role in inflammatory and allergic processes. Four genes are known to encode for these enzymes, with different alleles that give rise to different types of tryptases. The term "tryptase" generally refers to β-tryptase, which in vivo is a heterotetramer, possessing a structure of vital importance for enabling drug and substrate access to the active site of the molecule. Tryptase has been reported to possess antagonistic functions, since it plays an important role both in inflammatory phenomena and as a protector against infection. In allergic processes it is associated to bronchial hyperresponsiveness in asthmatic patients, where PAR-2 is of great importance as an airway receptor. Lastly, the genes that encode for tryptase are highly polymorphic and complex. As a result, it is important to establish a relationship between genotype and phenotype in disorders such as asthma, and to identify mutations that are presumably of pharmacological relevance. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10366/158971 |
| url |
http://hdl.handle.net/10366/158971 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
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Elservier |
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Elservier |
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reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca instname:Universidad de Salamanca (USAL) |
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Universidad de Salamanca (USAL) |
| reponame_str |
GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| collection |
GREDOS. Repositorio Institucional de la Universidad de Salamanca |
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1869410478327857152 |
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15,811543 |