Tryptase: genetic and functional considerations.
[EN] Tryptase is one of the main proteases located in the secretory granules of the mast cells, and is released through degranulation. It is therefore assumed to play an important role in inflammatory and allergic processes. Four genes are known to encode for these enzymes, with different alleles th...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2012 |
| País: | España |
| Institución: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/158971 |
| Acceso en línea: | http://hdl.handle.net/10366/158971 |
| Access Level: | acceso abierto |
| Palabra clave: | Tryptase SNP Mast cells Inflammation Genetic Predisposition to Disease Tryptases Mutation Inflammation Mediators Genetics Hypersensitivity Animals Mast Cells Humans Immunity Cell Degranulation Allergy and Immunology 3207.01 Alergias 2409 Genética hipersensibilidad alergia e inmunología animales humanos mastocitos triptasas mediadores de la inflamación mutación inmunidad desgranulación celular genética predisposición genética a la enfermedad |
| Sumario: | [EN] Tryptase is one of the main proteases located in the secretory granules of the mast cells, and is released through degranulation. It is therefore assumed to play an important role in inflammatory and allergic processes. Four genes are known to encode for these enzymes, with different alleles that give rise to different types of tryptases. The term "tryptase" generally refers to β-tryptase, which in vivo is a heterotetramer, possessing a structure of vital importance for enabling drug and substrate access to the active site of the molecule. Tryptase has been reported to possess antagonistic functions, since it plays an important role both in inflammatory phenomena and as a protector against infection. In allergic processes it is associated to bronchial hyperresponsiveness in asthmatic patients, where PAR-2 is of great importance as an airway receptor. Lastly, the genes that encode for tryptase are highly polymorphic and complex. As a result, it is important to establish a relationship between genotype and phenotype in disorders such as asthma, and to identify mutations that are presumably of pharmacological relevance. |
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