Cooperative Force Generation of KIF1A Brownian Motors

KIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of co...

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Detalles Bibliográficos
Autores: Oriola Santandreu, David|||0000-0002-8356-7832, Casademunt Viader, Jaume
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/378645
Acceso en línea:https://hdl.handle.net/2117/378645
https://dx.doi.org/10.1103/PhysRevLett.111.048103
Access Level:acceso abierto
Palabra clave:Protein kinases
Monomers
Proteïnes quinases
Monòmers
Àrees temàtiques de la UPC::Física
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spelling Cooperative Force Generation of KIF1A Brownian MotorsOriola Santandreu, David|||0000-0002-8356-7832Casademunt Viader, JaumeProtein kinasesMonomersProteïnes quinasesMonòmersÀrees temàtiques de la UPC::FísicaKIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of cooperative force generation, implying for instance that ~10 monomeric KIF1As can team up to become ~100 times stronger than a single one. Consequently, we propose that KIF1A could outperform conventional (double-headed) kinesin collectively and thus explain its specificity in axonal trafficking. We elucidate the cooperativity mechanism with a lattice model that includes multiparticle transitions.Peer ReviewedAmerican Institute of Physics (AIP)20132013-07-2620222022-12-16journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/2117/378645https://dx.doi.org/10.1103/PhysRevLett.111.048103reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3786452026-05-27T15:37:01Z
dc.title.none.fl_str_mv Cooperative Force Generation of KIF1A Brownian Motors
title Cooperative Force Generation of KIF1A Brownian Motors
spellingShingle Cooperative Force Generation of KIF1A Brownian Motors
Oriola Santandreu, David|||0000-0002-8356-7832
Protein kinases
Monomers
Proteïnes quinases
Monòmers
Àrees temàtiques de la UPC::Física
title_short Cooperative Force Generation of KIF1A Brownian Motors
title_full Cooperative Force Generation of KIF1A Brownian Motors
title_fullStr Cooperative Force Generation of KIF1A Brownian Motors
title_full_unstemmed Cooperative Force Generation of KIF1A Brownian Motors
title_sort Cooperative Force Generation of KIF1A Brownian Motors
dc.creator.none.fl_str_mv Oriola Santandreu, David|||0000-0002-8356-7832
Casademunt Viader, Jaume
author Oriola Santandreu, David|||0000-0002-8356-7832
author_facet Oriola Santandreu, David|||0000-0002-8356-7832
Casademunt Viader, Jaume
author_role author
author2 Casademunt Viader, Jaume
author2_role author
dc.subject.none.fl_str_mv Protein kinases
Monomers
Proteïnes quinases
Monòmers
Àrees temàtiques de la UPC::Física
topic Protein kinases
Monomers
Proteïnes quinases
Monòmers
Àrees temàtiques de la UPC::Física
description KIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of cooperative force generation, implying for instance that ~10 monomeric KIF1As can team up to become ~100 times stronger than a single one. Consequently, we propose that KIF1A could outperform conventional (double-headed) kinesin collectively and thus explain its specificity in axonal trafficking. We elucidate the cooperativity mechanism with a lattice model that includes multiparticle transitions.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-07-26
2022
2022-12-16
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/378645
https://dx.doi.org/10.1103/PhysRevLett.111.048103
url https://hdl.handle.net/2117/378645
https://dx.doi.org/10.1103/PhysRevLett.111.048103
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Institute of Physics (AIP)
publisher.none.fl_str_mv American Institute of Physics (AIP)
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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