Cooperative action of KIF1A Brownian motors with finite dwell time
We study in detail the cooperative action of small groups of KIF1A motors in its monomeric (single-headed) form within an arrangement relevant to vesicle traffic or membrane tube extraction. It has been recently shown that under these circumstances, the presence of a finite dwell time in the motor c...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2014 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/378633 |
| Acceso en línea: | https://hdl.handle.net/2117/378633 https://dx.doi.org/10.1103/PhysRevE.89.032722 |
| Access Level: | acceso abierto |
| Palabra clave: | Protein kinases Monomers Proteïnes quinases Monòmers Àrees temàtiques de la UPC::Física |
| Sumario: | We study in detail the cooperative action of small groups of KIF1A motors in its monomeric (single-headed) form within an arrangement relevant to vesicle traffic or membrane tube extraction. It has been recently shown that under these circumstances, the presence of a finite dwell time in the motor cycle contributes to remarkably enhance collective force generation [D. Oriola and J. Casademunt, Phys. Rev. Lett. 111, 048103 (2013)]. We analyze this mechanism in detail by means of a two-state noise-driven ratchet model with hard-core repulsive interactions. We obtain staircase-shaped velocity-force curves and show that motors self-organize in clusters with a nontrivial force distribution that conveys a large part of the load to the central motors. Under heavy loads, large clusters adopt a synchronic mode of totally asymmetric steps. We also find a dramatic increase of the collective efficiency with the number of motors. Finally, we complete the study by addressing different interactions that impose spatial constraints such as rigid coupling and raft-induced confinement. Our results reinforce the hypothesis that the specificity of KIF1A to axonal vesicular transport may be deeply related to its high cooperativity. |
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