Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions

Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the brain parenchyma, gliosis and, axonal damage. The etiology is still unknown but it...

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Author: Muñoz San Martín, María
Format: doctoral thesis
Status:Published version
Publication Date:2021
Country:España
Institution:CBUC, CESCA
Repository:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/672871
Online Access:http://hdl.handle.net/10803/672871
Access Level:Open access
Keyword:Esclerosi múltiple
Esclerosis múltiple
Multiple sclerosis
microRNAs
Epigenètica
Epigenética
Epigenetics
Líquid cefaloraquidi
Líquido cefalorraquídeo
Cerebrospinal fluid
Biomarcadors
Biomarcadores
Biomarkers
575
616.8
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oai_identifier_str oai:www.tdx.cat:10803/672871
network_acronym_str ES
network_name_str España
repository_id_str
spelling Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditionsMuñoz San Martín, MaríaEsclerosi múltipleEsclerosis múltipleMultiple sclerosismicroRNAsEpigenèticaEpigenéticaEpigeneticsLíquid cefaloraquidiLíquido cefalorraquídeoCerebrospinal fluidBiomarcadorsBiomarcadoresBiomarkers575616.8Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the brain parenchyma, gliosis and, axonal damage. The etiology is still unknown but it has been suggested that some epigenetic mechanisms such as microRNAs (miRNAs) are involved in the complex interaction between some genetic and environmental factors producing the pathology and the symptoms in MS. miRNAs might regulate gene expression post-transcriptionally. They also present many properties to be considered as promising biomarkers for different pathological conditions as they could be released into biological fluids. In this doctoral thesis, specific miRNA signatures in different clinical and pre- clinical forms of MS are described. Altogether, miR-21-5p, miR-20a-5p, miR-142-5p, miR-143-3p, miR-146a-5p and miR-448 are proposed as potential miRNA candidates involved in MS pathogenesis as their deregulation has been manifested in different sub-studiesLa esclerosis múltiple (EM) es considerada una enfermedad crónica, inflamatoria y neurodegenerativa, caracterizada por la existencia de áreas desmielinizadas en el sistema nervioso central, infiltración de células inflamatorias en el parénquima cerebral, gliosis y daño axonal. La etiología aún se desconoce, pero se cree que diferentes mecanismos epigenéticos como los microRNAs (miRNAs) influyen en la compleja interacción entre factores genéticos y ambientales que producen la patología y los síntomas en la EM. miRNAs son capaces de regular la expresión génica postranscripcionalmente y presentan, a su vez, muchas propiedades para ser considerados potenciales biomarcadores en diferentes condiciones patológicas. En esta tesis doctoral se describen perfiles de miRNAs específicos en diferentes formas clínicas y preclínicas de EM. En resumen, miR-21-5p, miR- 20a-5p, miR-142-5p, miR-143-3p, miR-146a-5p y miR- 448 se proponen como posibles miRNAs candidatos a estar involucrados en la patogénesis de la EM ya que su desregulación se ha observado en diferentes subestudiosPrograma de Doctorat en Biologia Molecular, Biomedicina i SalutUniversitat de GironaQuintana Camps, EsterRamió i Torrentà, LluísKádár García, ElisabethUniversitat de Girona. Departament de Ciències MèdiquesUniversitat de Girona. Departament de Biologia202120212021info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion343 p.application/pdfapplication/pdfhttp://hdl.handle.net/10803/672871TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésADVERTIMENT. Tots els drets reservats. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al servei TDX. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs.info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/6728712026-06-14T12:46:07Z
dc.title.none.fl_str_mv Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions
title Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions
spellingShingle Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions
Muñoz San Martín, María
Esclerosi múltiple
Esclerosis múltiple
Multiple sclerosis
microRNAs
Epigenètica
Epigenética
Epigenetics
Líquid cefaloraquidi
Líquido cefalorraquídeo
Cerebrospinal fluid
Biomarcadors
Biomarcadores
Biomarkers
575
616.8
title_short Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions
title_full Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions
title_fullStr Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions
title_full_unstemmed Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions
title_sort Role of miRNAs in multiple sclerosis: study of miRNAs in cerebrospinal fluid for different clinical conditions
dc.creator.none.fl_str_mv Muñoz San Martín, María
author Muñoz San Martín, María
author_facet Muñoz San Martín, María
author_role author
dc.contributor.none.fl_str_mv Quintana Camps, Ester
Ramió i Torrentà, Lluís
Kádár García, Elisabeth
Universitat de Girona. Departament de Ciències Mèdiques
Universitat de Girona. Departament de Biologia
dc.subject.none.fl_str_mv Esclerosi múltiple
Esclerosis múltiple
Multiple sclerosis
microRNAs
Epigenètica
Epigenética
Epigenetics
Líquid cefaloraquidi
Líquido cefalorraquídeo
Cerebrospinal fluid
Biomarcadors
Biomarcadores
Biomarkers
575
616.8
topic Esclerosi múltiple
Esclerosis múltiple
Multiple sclerosis
microRNAs
Epigenètica
Epigenética
Epigenetics
Líquid cefaloraquidi
Líquido cefalorraquídeo
Cerebrospinal fluid
Biomarcadors
Biomarcadores
Biomarkers
575
616.8
description Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the brain parenchyma, gliosis and, axonal damage. The etiology is still unknown but it has been suggested that some epigenetic mechanisms such as microRNAs (miRNAs) are involved in the complex interaction between some genetic and environmental factors producing the pathology and the symptoms in MS. miRNAs might regulate gene expression post-transcriptionally. They also present many properties to be considered as promising biomarkers for different pathological conditions as they could be released into biological fluids. In this doctoral thesis, specific miRNA signatures in different clinical and pre- clinical forms of MS are described. Altogether, miR-21-5p, miR-20a-5p, miR-142-5p, miR-143-3p, miR-146a-5p and miR-448 are proposed as potential miRNA candidates involved in MS pathogenesis as their deregulation has been manifested in different sub-studies
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/672871
url http://hdl.handle.net/10803/672871
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 343 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universitat de Girona
publisher.none.fl_str_mv Universitat de Girona
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410416735551488
score 15,301603

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