Changes in Liver Lipidomic Profile in G2019S-LRRK2 Mouse Model of Parkinson’s Disease

The identification of Parkinson’s disease (PD) biomarkers has become a main goal for the diagnosis of this neurodegenerative disorder. PD has not only been intrinsically related to neurological problems, but also to a series of alterations in peripheral metabolism. The purpose of this study was to i...

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Detalles Bibliográficos
Autores: Yakhine Diop, Sokhna M. S., Moreno Cruz, Paula, Manrique García, Laura, Gabrielly Pereira, Amanda, Morales García, José Ángel, Corral Nieto, Yaiza, Niso Santano, Mireia, González Polo, Rosa A., Uribe Carretero, Elisabet, Durand, Sylvère, Maiuri, Maria Chiara, Paredes Barquero, Marta, Alegre Cortés, Eva, Canales Cortés, Saray, López de Munain, Adolfo, Pérez Tur, Jordi, Pérez Castillo, Ana, Kroemer, Guido, Fuentes, José M., Bravo San Pedro, José M.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/72403
Acceso en línea:https://hdl.handle.net/20.500.14352/72403
Access Level:acceso abierto
Palabra clave:Lipids
Liver
LRRK2
Metabolome
Neurodegeneration
Parkinson
Psicología (Psicología)
Veterinaria
61 Psicología
3109 Ciencias Veterinarias
Descripción
Sumario:The identification of Parkinson’s disease (PD) biomarkers has become a main goal for the diagnosis of this neurodegenerative disorder. PD has not only been intrinsically related to neurological problems, but also to a series of alterations in peripheral metabolism. The purpose of this study was to identify metabolic changes in the liver in mouse models of PD with the scope of finding new peripheral biomarkers for PD diagnosis. To achieve this goal, we used mass spectrometry technology to determine the complete metabolomic profile of liver and striatal tissue samples from WT mice, 6-hydroxydopamine-treated mice (idiopathic model) and mice affected by the G2019S-LRRK2 mutation in LRRK2/PARK8 gene (genetic model). This analysis revealed that the metabolism of carbohydrates, nucleotides and nucleosides was similarly altered in the liver from the two PD mouse models. However, long-chain fatty acids, phosphatidylcholine and other related lipid metabolites were only altered in hepatocytes from G2019S-LRRK2 mice. In summary, these results reveal specific differences, mainly in lipid metabolism, between idiopathic and genetic PD models in peripheral tissues and open up new possibilities to better understand the etiology of this neurological disorder.

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