Increased Stroke Risk in Patients with Parkinson’s Disease with LRRK2 Mutations

Parkinson’s disease (PD) is associated with an increasedstroke risk, however, no relationship between coronary arterydisease (CAD) and PD was found.1To date, little is knownabout the influence of PD-related genes, such as the leucine-rich repeat kinase 2 (LRRK2), the parkin (PRKN) and theglucocerebr...

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Detalles Bibliográficos
Autores: Macías-García, Daniel, Periñán Tocino, María Teresa, Muñoz Delgado, Laura, Jesús, Silvia, Jiménez Jaraba, María Valle, Buiza Rueda, Dolores, Bonilla Toribio, Marta, Adarmes-Gómez, Astrid, Carrillo García, Fátima María, Gómez Garre, Pilar, Mir Rivera, Pablo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/140346
Acceso en línea:https://hdl.handle.net/11441/140346
https://doi.org/10.1002/mds.28863
Access Level:acceso abierto
Palabra clave:Parkinson’s disease
LRRK2 Mutations
Stroke Risk
Descripción
Sumario:Parkinson’s disease (PD) is associated with an increasedstroke risk, however, no relationship between coronary arterydisease (CAD) and PD was found.1To date, little is knownabout the influence of PD-related genes, such as the leucine-rich repeat kinase 2 (LRRK2), the parkin (PRKN) and theglucocerebrosidase (GBA) genes, in the vascular risk of thesepatients. This work aims to determine whether the vascularrisk differs between sporadic/familial PD forms and controls.

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