Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice

Background: In early stages of Alzheimers disease (AD), soluble amyloid-ß (Aß) is a key player disrupting neuronal activity and contributing to cognitive decline in advanced stages of the disease. While the hippocampus has been a central focus in prior research due to its susceptibility to Aß-induce...

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Autores: Djebari, Souhail, Contreras Marín, Ana, Castro Andrés, Víctor, Jiménez Herrera, Raquel, Iborra Lázaro, Guillermo, Sánchez Campusano, Raudel, Jiménez Díaz, Lydia, Navarro López, Juan de Dios
Formato: artículo
Fecha de publicación:2026
País:España
Recursos:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/47765
Acesso em linha:https://doi.org/10.1113/JP286196Digital Object Identifier (DOI)
https://hdl.handle.net/10578/47765
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP286196
Access Level:acceso abierto
Palavra-chave:alzheimer’s disease
amyloid-ß
hippocampus
oligomers
oscillatory activity
posterior parietal cortex
spatial memory
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spelling Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male miceDjebari, SouhailContreras Marín, AnaCastro Andrés, VíctorJiménez Herrera, RaquelIborra Lázaro, GuillermoSánchez Campusano, RaudelJiménez Díaz, LydiaNavarro López, Juan de Diosalzheimer’s diseaseamyloid-ßhippocampusoligomersoscillatory activityposterior parietal cortexspatial memoryBackground: In early stages of Alzheimers disease (AD), soluble amyloid-ß (Aß) is a key player disrupting neuronal activity and contributing to cognitive decline in advanced stages of the disease. While the hippocampus has been a central focus in prior research due to its susceptibility to Aß-induced alterations, a comprehensive understanding of early AD pathology requires exploring interconnected brain regions. The posterior parietal cortex (PPC), collaborating closely with the hippocampus and involved in various memory processes, particularly spatial memory formation, holds particular significance. Investigating the PPCs function is imperative, as it may contribute to early AD characteristics and provide a more holistic perspective on disease progression.Methods: To address this gap, we examined the relationship between neural oscillations and memory processes in the PPC and hippocampus in a mouse model of early hippocampal amyloidosis generated by intracerebroventricular oligomeric Aß1-42 (oAß1-42) injections by performing in vivo oscillatory activity recordings from these regions in alert animals, together with spatial and habituation memory tests (Barnes maze and open field habituation).Results: We found oAß1-42 to induce significant alterations in PPC oscillatory activity emerging several days after hippocampal disturbances showed by aberrant long-term potentiation (LTP) and network activity. Additionally, non-significant alterations of stereotyped behaviors were found.Conclusions: Our results indicate that these atypical patterns provide insight into the persistent spatial memory deficits observed in our amyloidosis model and the temporal progression of the deleterious effects caused by Aß. Furthermore, they support the potential use of PPC oscillatory activity as a valuable tool for early detection and intervention in AD.Research Square202620262026info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://doi.org/10.1113/JP286196Digital Object Identifier (DOI)https://hdl.handle.net/10578/47765https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP286196reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaIngléssubvenciones MCIN/AEI/10.13039/501100011033 (subvenciones PID2020-115823-GBI00; PID2024-155413NB-I00)JCCM/FEDER: una manera de hacer Europa (subvenciones SBPLY/21/180501/000150; SBPLY/24/180225/000181)UCLM/FEDER (subvenciones 2022-GRIN-34354; 2025-GRIN-38530)ANDALUCÍA/FEDER (UPO-1380660)MCIN/AEI (PID2022-141997NB-I00)beca de investigación postdoctoral Margarita Salas (2021-MS-20549), financiada por el programa NextGenerationEU/PRTR de la Unión Europeabeca predoctoral del Programa Plan Propio de Investigación UCLM/ESFinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/477652026-05-27T07:36:41Z
dc.title.none.fl_str_mv Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice
title Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice
spellingShingle Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice
Djebari, Souhail
alzheimer’s disease
amyloid-ß
hippocampus
oligomers
oscillatory activity
posterior parietal cortex
spatial memory
title_short Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice
title_full Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice
title_fullStr Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice
title_full_unstemmed Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice
title_sort Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice
dc.creator.none.fl_str_mv Djebari, Souhail
Contreras Marín, Ana
Castro Andrés, Víctor
Jiménez Herrera, Raquel
Iborra Lázaro, Guillermo
Sánchez Campusano, Raudel
Jiménez Díaz, Lydia
Navarro López, Juan de Dios
author Djebari, Souhail
author_facet Djebari, Souhail
Contreras Marín, Ana
Castro Andrés, Víctor
Jiménez Herrera, Raquel
Iborra Lázaro, Guillermo
Sánchez Campusano, Raudel
Jiménez Díaz, Lydia
Navarro López, Juan de Dios
author_role author
author2 Contreras Marín, Ana
Castro Andrés, Víctor
Jiménez Herrera, Raquel
Iborra Lázaro, Guillermo
Sánchez Campusano, Raudel
Jiménez Díaz, Lydia
Navarro López, Juan de Dios
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv alzheimer’s disease
amyloid-ß
hippocampus
oligomers
oscillatory activity
posterior parietal cortex
spatial memory
topic alzheimer’s disease
amyloid-ß
hippocampus
oligomers
oscillatory activity
posterior parietal cortex
spatial memory
description Background: In early stages of Alzheimers disease (AD), soluble amyloid-ß (Aß) is a key player disrupting neuronal activity and contributing to cognitive decline in advanced stages of the disease. While the hippocampus has been a central focus in prior research due to its susceptibility to Aß-induced alterations, a comprehensive understanding of early AD pathology requires exploring interconnected brain regions. The posterior parietal cortex (PPC), collaborating closely with the hippocampus and involved in various memory processes, particularly spatial memory formation, holds particular significance. Investigating the PPCs function is imperative, as it may contribute to early AD characteristics and provide a more holistic perspective on disease progression.Methods: To address this gap, we examined the relationship between neural oscillations and memory processes in the PPC and hippocampus in a mouse model of early hippocampal amyloidosis generated by intracerebroventricular oligomeric Aß1-42 (oAß1-42) injections by performing in vivo oscillatory activity recordings from these regions in alert animals, together with spatial and habituation memory tests (Barnes maze and open field habituation).Results: We found oAß1-42 to induce significant alterations in PPC oscillatory activity emerging several days after hippocampal disturbances showed by aberrant long-term potentiation (LTP) and network activity. Additionally, non-significant alterations of stereotyped behaviors were found.Conclusions: Our results indicate that these atypical patterns provide insight into the persistent spatial memory deficits observed in our amyloidosis model and the temporal progression of the deleterious effects caused by Aß. Furthermore, they support the potential use of PPC oscillatory activity as a valuable tool for early detection and intervention in AD.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1113/JP286196Digital Object Identifier (DOI)
https://hdl.handle.net/10578/47765
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP286196
url https://doi.org/10.1113/JP286196Digital Object Identifier (DOI)
https://hdl.handle.net/10578/47765
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP286196
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv subvenciones MCIN/AEI/10.13039/501100011033 (subvenciones PID2020-115823-GBI00; PID2024-155413NB-I00)
JCCM/FEDER: una manera de hacer Europa (subvenciones SBPLY/21/180501/000150; SBPLY/24/180225/000181)
UCLM/FEDER (subvenciones 2022-GRIN-34354; 2025-GRIN-38530)
ANDALUCÍA/FEDER (UPO-1380660)
MCIN/AEI (PID2022-141997NB-I00)
beca de investigación postdoctoral Margarita Salas (2021-MS-20549), financiada por el programa NextGenerationEU/PRTR de la Unión Europea
beca predoctoral del Programa Plan Propio de Investigación UCLM/ESF
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Research Square
publisher.none.fl_str_mv Research Square
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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