Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice
Background: In early stages of Alzheimers disease (AD), soluble amyloid-ß (Aß) is a key player disrupting neuronal activity and contributing to cognitive decline in advanced stages of the disease. While the hippocampus has been a central focus in prior research due to its susceptibility to Aß-induce...
| Autores: | , , , , , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2026 |
| País: | España |
| Recursos: | Universidad de Castilla-La Mancha |
| Repositório: | RUIdeRA. Repositorio Institucional de la UCLM |
| OAI Identifier: | oai:ruidera.uclm.es:10578/47765 |
| Acesso em linha: | https://doi.org/10.1113/JP286196Digital Object Identifier (DOI) https://hdl.handle.net/10578/47765 https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP286196 |
| Access Level: | Acceso aberto |
| Palavra-chave: | alzheimer’s disease amyloid-ß hippocampus oligomers oscillatory activity posterior parietal cortex spatial memory |
| Resumo: | Background: In early stages of Alzheimers disease (AD), soluble amyloid-ß (Aß) is a key player disrupting neuronal activity and contributing to cognitive decline in advanced stages of the disease. While the hippocampus has been a central focus in prior research due to its susceptibility to Aß-induced alterations, a comprehensive understanding of early AD pathology requires exploring interconnected brain regions. The posterior parietal cortex (PPC), collaborating closely with the hippocampus and involved in various memory processes, particularly spatial memory formation, holds particular significance. Investigating the PPCs function is imperative, as it may contribute to early AD characteristics and provide a more holistic perspective on disease progression.Methods: To address this gap, we examined the relationship between neural oscillations and memory processes in the PPC and hippocampus in a mouse model of early hippocampal amyloidosis generated by intracerebroventricular oligomeric Aß1-42 (oAß1-42) injections by performing in vivo oscillatory activity recordings from these regions in alert animals, together with spatial and habituation memory tests (Barnes maze and open field habituation).Results: We found oAß1-42 to induce significant alterations in PPC oscillatory activity emerging several days after hippocampal disturbances showed by aberrant long-term potentiation (LTP) and network activity. Additionally, non-significant alterations of stereotyped behaviors were found.Conclusions: Our results indicate that these atypical patterns provide insight into the persistent spatial memory deficits observed in our amyloidosis model and the temporal progression of the deleterious effects caused by Aß. Furthermore, they support the potential use of PPC oscillatory activity as a valuable tool for early detection and intervention in AD. |
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