Molecular Management of High-Grade Serous Ovarian Carcinoma.

High-grade serous ovarian carcinoma (HGSOC) represents the most common form of epithelial ovarian carcinoma. The absence of specific symptoms leads to late-stage diagnosis, making HGSOC one of the gynecological cancers with the worst prognosis. The cellular origin of HGSOC and the role of reproducti...

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Autores: Punzon-Jimenez, Paula, Lago, Victor, Domingo, Santiago, Simon, Carlos, Mas, Aymara
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p17030
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/17030
Access Level:acceso abierto
Palabra clave:early diagnosis
high-grade serous ovarian carcinoma
liquid biopsy
molecular biomarkers
ovarian cancer
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spelling Molecular Management of High-Grade Serous Ovarian Carcinoma.Punzon-Jimenez, PaulaLago, VictorDomingo, SantiagoSimon, CarlosMas, Aymaraearly diagnosishigh-grade serous ovarian carcinomaliquid biopsymolecular biomarkersovarian cancerHigh-grade serous ovarian carcinoma (HGSOC) represents the most common form of epithelial ovarian carcinoma. The absence of specific symptoms leads to late-stage diagnosis, making HGSOC one of the gynecological cancers with the worst prognosis. The cellular origin of HGSOC and the role of reproductive hormones, genetic traits (such as alterations in P53 and DNA-repair mechanisms), chromosomal instability, or dysregulation of crucial signaling pathways have been considered when evaluating prognosis and response to therapy in HGSOC patients. However, the detection of HGSOC is still based on traditional methods such as carbohydrate antigen 125 (CA125) detection and ultrasound, and the combined use of these methods has yet to support significant reductions in overall mortality rates. The current paradigm for HGSOC management has moved towards early diagnosis via the non-invasive detection of molecular markers through liquid biopsies. This review presents an integrated view of the relevant cellular and molecular aspects involved in the etiopathogenesis of HGSOC and brings together studies that consider new horizons for the possible early detection of this gynecological cancer.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/17030INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESISSN: 16616596ISSNe: 14220067reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p170302026-06-07T16:35:31Z
dc.title.none.fl_str_mv Molecular Management of High-Grade Serous Ovarian Carcinoma.
title Molecular Management of High-Grade Serous Ovarian Carcinoma.
spellingShingle Molecular Management of High-Grade Serous Ovarian Carcinoma.
Punzon-Jimenez, Paula
early diagnosis
high-grade serous ovarian carcinoma
liquid biopsy
molecular biomarkers
ovarian cancer
title_short Molecular Management of High-Grade Serous Ovarian Carcinoma.
title_full Molecular Management of High-Grade Serous Ovarian Carcinoma.
title_fullStr Molecular Management of High-Grade Serous Ovarian Carcinoma.
title_full_unstemmed Molecular Management of High-Grade Serous Ovarian Carcinoma.
title_sort Molecular Management of High-Grade Serous Ovarian Carcinoma.
dc.creator.none.fl_str_mv Punzon-Jimenez, Paula
Lago, Victor
Domingo, Santiago
Simon, Carlos
Mas, Aymara
author Punzon-Jimenez, Paula
author_facet Punzon-Jimenez, Paula
Lago, Victor
Domingo, Santiago
Simon, Carlos
Mas, Aymara
author_role author
author2 Lago, Victor
Domingo, Santiago
Simon, Carlos
Mas, Aymara
author2_role author
author
author
author
dc.subject.none.fl_str_mv early diagnosis
high-grade serous ovarian carcinoma
liquid biopsy
molecular biomarkers
ovarian cancer
topic early diagnosis
high-grade serous ovarian carcinoma
liquid biopsy
molecular biomarkers
ovarian cancer
description High-grade serous ovarian carcinoma (HGSOC) represents the most common form of epithelial ovarian carcinoma. The absence of specific symptoms leads to late-stage diagnosis, making HGSOC one of the gynecological cancers with the worst prognosis. The cellular origin of HGSOC and the role of reproductive hormones, genetic traits (such as alterations in P53 and DNA-repair mechanisms), chromosomal instability, or dysregulation of crucial signaling pathways have been considered when evaluating prognosis and response to therapy in HGSOC patients. However, the detection of HGSOC is still based on traditional methods such as carbohydrate antigen 125 (CA125) detection and ultrasound, and the combined use of these methods has yet to support significant reductions in overall mortality rates. The current paradigm for HGSOC management has moved towards early diagnosis via the non-invasive detection of molecular markers through liquid biopsies. This review presents an integrated view of the relevant cellular and molecular aspects involved in the etiopathogenesis of HGSOC and brings together studies that consider new horizons for the possible early detection of this gynecological cancer.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/17030
url https://incliva.portalinvestigacion.com/publicaciones/17030
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN: 16616596
ISSNe: 14220067
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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