Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm-Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice

[Scope] Our laboratory has previously described the antioxidant and anti-inflammatory potential of a wild olive (acebuche, ACE) oil against hypertension-associated vascular retinopathies. The current study aims to analyze the antifibrotic effect of ACE oil on the retina of hypertensive mice.

Detalles Bibliográficos
Autores: Santana-Garrido, Álvaro, Reyes-Goya, Claudia, André, Helder, Vázquez, Carmen M., Mate, Alfonso
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/360435
Acceso en línea:http://hdl.handle.net/10261/360435
https://api.elsevier.com/content/abstract/scopus_id/85178422557
Access Level:acceso abierto
Palabra clave:Retina
Acebuche
Arterial hypertension
Fibrosis
Olive oil
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spelling Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm-Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive MiceSantana-Garrido, ÁlvaroReyes-Goya, ClaudiaAndré, HelderVázquez, Carmen M.Mate, AlfonsoRetinaAcebucheArterial hypertensionFibrosisOlive oil[Scope] Our laboratory has previously described the antioxidant and anti-inflammatory potential of a wild olive (acebuche, ACE) oil against hypertension-associated vascular retinopathies. The current study aims to analyze the antifibrotic effect of ACE oil on the retina of hypertensive mice.[Methods and results] Mice are rendered hypertensive by administration of NG-nitro-L-arginine-methyl-ester (L-NAME) and simultaneously subjected to dietary supplementation with ACE oil or a reference extra virgin olive oil (EVOO). Intraocular pressure (IOP) is measured by rebound tonometry, and retinal vasculature/layers are analyzed by fundus fluorescein angiography and optical coherence tomography. Different fibrosis-related parameters are analyzed in the retina and choroid of normotensive and hypertensive mice with or without oil supplementation. Besides preventing the alterations found in hypertensive animals, including increased IOP, reduced fluorescein signal, and altered retinal layer thickness, the ACE oil-enriched diet improves collagen metabolism by regulating the expression of major fibrotic process modulators (matrix metalloproteinases, tissue inhibitors of metalloproteinases, connective tissue growth factor, and transforming growth factor beta family).[Conclusion] Regular consumption of EVOO and ACE oil (with better outcomes in the latter) might help reduce abnormally high IOP values in the context of hypertension-related retinal damage, with significant reduction in the surrounding fibrotic process.This research was supported by Grant PID2019-109002RB-I00 funded by MCIN/AEI/10.13039/501100011033; and Junta de Andalucía, Consejería de Universidad, Investigación e Innovación, Secretaría General de Investigación e Innovación, ProyExcel_00516. Á.S.-G is a recipient of an FPU predoctoral fellowship from Ministerio de Universidades (FPU17/03465). Part of the results reported here were obtained during a mobility grant funded by the program Ayudas complementarias para estancias breves y traslados temporales, subprograma de Formación del Profesorado Universitario, Ministerio de Ciencia, Innovación y Universidades (EST19/00305). C.M.V received a mobility grant funded by the program Ayudas para la movilidad internacional del personal dedicado a la investigación, Universidad de Sevilla, to supervise part of the results obtained in this work at Karolinska Institutet. We are thankful for the technical support from Centro de Innovación, Tecnología e Innovación de la Universidad de Sevilla (CITIUS, Servicio de Biología, Servicio de Microscopía).Peer reviewedJohn Wiley & SonsMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Junta de AndalucíaMinisterio de Universidades (España)Ministerio de Ciencia, Innovación y Universidades (España)Universidad de SevillaMate, Alfonso [0000-0002-2719-8825]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/360435https://api.elsevier.com/content/abstract/scopus_id/85178422557reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109002RB-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1002/mnfr.202200623https://doi.org/10.1002/mnfr.202200623Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3604352026-05-22T06:33:51Z
dc.title.none.fl_str_mv Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm-Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice
title Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm-Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice
spellingShingle Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm-Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice
Santana-Garrido, Álvaro
Retina
Acebuche
Arterial hypertension
Fibrosis
Olive oil
title_short Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm-Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice
title_full Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm-Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice
title_fullStr Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm-Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice
title_full_unstemmed Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm-Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice
title_sort Exploring the Potential of Wild Olive (Acebuche) Oil as a Pharm-Food to Prevent Ocular Hypertension and Fibrotic Events in the Retina of Hypertensive Mice
dc.creator.none.fl_str_mv Santana-Garrido, Álvaro
Reyes-Goya, Claudia
André, Helder
Vázquez, Carmen M.
Mate, Alfonso
author Santana-Garrido, Álvaro
author_facet Santana-Garrido, Álvaro
Reyes-Goya, Claudia
André, Helder
Vázquez, Carmen M.
Mate, Alfonso
author_role author
author2 Reyes-Goya, Claudia
André, Helder
Vázquez, Carmen M.
Mate, Alfonso
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Junta de Andalucía
Ministerio de Universidades (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Universidad de Sevilla
Mate, Alfonso [0000-0002-2719-8825]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Retina
Acebuche
Arterial hypertension
Fibrosis
Olive oil
topic Retina
Acebuche
Arterial hypertension
Fibrosis
Olive oil
description [Scope] Our laboratory has previously described the antioxidant and anti-inflammatory potential of a wild olive (acebuche, ACE) oil against hypertension-associated vascular retinopathies. The current study aims to analyze the antifibrotic effect of ACE oil on the retina of hypertensive mice.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/360435
https://api.elsevier.com/content/abstract/scopus_id/85178422557
url http://hdl.handle.net/10261/360435
https://api.elsevier.com/content/abstract/scopus_id/85178422557
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109002RB-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1002/mnfr.202200623
https://doi.org/10.1002/mnfr.202200623
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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