Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease

This article belongs to the Section Phytochemicals and Human Health.

Detalles Bibliográficos
Autores: Preciado, Silvia, Martínez-Villaluenga, Cristina, Rico, Daniel, Muntión, Sandra, García-Macías, María-Carmen, Navarro-Bailón, Almudena, Martín Diana, Ana Belén, Sánchez-Guijo, Fermín
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/345124
Acceso en línea:http://hdl.handle.net/10261/345124
Access Level:acceso abierto
Palabra clave:Wheat bran
Mouse model
Ferulic acid
Immunomodulation
Graft-versus-host disease
Anti-inflammatory activity
id ES_6d53d717c94ac84471ed5cd1dfc4e045
oai_identifier_str oai:digital.csic.es:10261/345124
network_acronym_str ES
network_name_str España
repository_id_str
spelling Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host diseasePreciado, SilviaMartínez-Villaluenga, CristinaRico, DanielMuntión, SandraGarcía-Macías, María-CarmenNavarro-Bailón, AlmudenaMartín Diana, Ana BelénSánchez-Guijo, FermínWheat branMouse modelFerulic acidImmunomodulationGraft-versus-host diseaseAnti-inflammatory activityThis article belongs to the Section Phytochemicals and Human Health.Graft-versus-host disease (GvHD) is a common and severe complication following allogeneic hematopoietic stem cell transplantation (HSCT). Its prevention and treatment is a major challenge. Ferulic acid (FA) has anti-inflammatory and antioxidant properties that could be attractive in this setting. Our aim was to evaluate a bioactive ingredient derived from wheat bran (WB), selected for its high concentration of FA, in a murine model of GvHD. The ingredient was obtained via a bioprocess involving hydrolysis and spray-drying. GvHD was induced via HSCT between MHC-mismatched mouse strains. FA treatment was administered orally. Survival and disease scores (weight loss, hunching, activity, fur texture, and skin integrity, each scored between 0 and 2 depending on disease severity) were recorded daily, histological evaluation was performed at the end of the experiment, and serum inflammatory cytokines were analyzed on days 9 and 28. Treatment with FA did not protect GvHD mice from death, nor did it diminish GvHD scores. However, histological analysis showed that ulcers with large areas of inflammatory cells, vessels, and keratin were less common in skin samples from FA-treated mice. Areas of intense inflammatory response were also seen in fewer small intestine samples from treated mice. In addition, a slight decrease in INF-γ and TNF-α expression was observed in the serum of treated mice on day 28. The results showed some local effect of the ingredient intervention, but that the dose used may not be sufficient to control or reduce the inflammatory response at the systemic level in mice with GvHD. Higher dosages of FA may have an impact when evaluating the immunomodulatory capabilities of the hydrolyzed WB ingredient. Thus, further experiments and the use of technological strategies that enrich the ingredients in soluble ferulic acid to improve its efficacy in this setting are warranted.This work was partially supported by Agencia Estatal de Investigación/FEDER, UE (AGL2017-83718-R), Instituto de Salud Carlos III (PI16/01407) and by Consejería de Educación (CAS079P17) and Consejería de Sanidad (GRS1879/A/18) of the Junta de Castilla y León. SP is supported by Fundación Española de Hematología y Hemoterapia (FEHH). SM is supported by RETIC program of ISCIII-European Regional Development Fund (RD21/0017/0006), “A way to make Europe”.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Ministerio de Ciencia e Innovación (España)Instituto de Salud Carlos IIIAgencia Estatal de Investigación (España)Junta de Castilla y LeónFundacion de la Sociedad Española de Hematología y HemoterapiaEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/345124reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-83718-Rhttps://doi.org/10.3390/nu15214582Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3451242026-05-22T06:33:51Z
dc.title.none.fl_str_mv Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
title Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
spellingShingle Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
Preciado, Silvia
Wheat bran
Mouse model
Ferulic acid
Immunomodulation
Graft-versus-host disease
Anti-inflammatory activity
title_short Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
title_full Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
title_fullStr Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
title_full_unstemmed Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
title_sort Effects of dietary supplementation with a ferulic acid-rich bioactive component of wheat bran in a murine model of graft-versus-host disease
dc.creator.none.fl_str_mv Preciado, Silvia
Martínez-Villaluenga, Cristina
Rico, Daniel
Muntión, Sandra
García-Macías, María-Carmen
Navarro-Bailón, Almudena
Martín Diana, Ana Belén
Sánchez-Guijo, Fermín
author Preciado, Silvia
author_facet Preciado, Silvia
Martínez-Villaluenga, Cristina
Rico, Daniel
Muntión, Sandra
García-Macías, María-Carmen
Navarro-Bailón, Almudena
Martín Diana, Ana Belén
Sánchez-Guijo, Fermín
author_role author
author2 Martínez-Villaluenga, Cristina
Rico, Daniel
Muntión, Sandra
García-Macías, María-Carmen
Navarro-Bailón, Almudena
Martín Diana, Ana Belén
Sánchez-Guijo, Fermín
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Ministerio de Ciencia e Innovación (España)
Instituto de Salud Carlos III
Agencia Estatal de Investigación (España)
Junta de Castilla y León
Fundacion de la Sociedad Española de Hematología y Hemoterapia
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Wheat bran
Mouse model
Ferulic acid
Immunomodulation
Graft-versus-host disease
Anti-inflammatory activity
topic Wheat bran
Mouse model
Ferulic acid
Immunomodulation
Graft-versus-host disease
Anti-inflammatory activity
description This article belongs to the Section Phytochemicals and Human Health.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/345124
url http://hdl.handle.net/10261/345124
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-83718-R
https://doi.org/10.3390/nu15214582
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410344325087232
score 15,811543

Similares en LA Referencia