Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys

CONTEXT: The scarcity of cross-national reports and the changes in Diagnostic and Statistical Manual version 5 (DSM-5) regarding panic disorder (PD) and panic attacks (PAs) call for new epidemiological data on PD and PAs and its subtypes in the general population. OBJECTIVE: To present representativ...

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Authors: Jonge, Peter de, Roest, Annelieke M., Lim, Carmen C. W., Florescu, Silvia E., Bromet, Evelyn J., Stein, Dan J., 1962-, Harris, Meredith G., Nakov, Vladimir, Caldas de Almeida, José Miguel, Levinson, Daphna, Al-Hamzawi, Ali Obaid, Haro Abad, Josep Maria, Viana, Maria Carmen, Borgs, Gui, O'Neill, Siobhan, Girolamo, Giovanni de, Demyttenaere, Koen, Gureje, Oye, Iwata, Noboru, Lee, Sing, Hu, Chiyi, Karam, Aimee, Moskalewicz, Jacek, Kovess-Masfety, Viviane, Navarro Mateu, Fernando, Oakley Browne, Mark, Piazza, Maria, Posada Villa, José, Torres, Yolanda, Have, Margreet ten, Kessler, Ronald C., Scott, Kate M. (Kate Margaret), 1960-
Format: article
Status:Versión aceptada para publicación
Publication Date:2016
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/128129
Online Access:https://hdl.handle.net/2445/128129
Access Level:Open access
Keyword:Atacs de pànic
Trastorns de pànic
Epidemiologia
Panic attacks
Panic disorders
Epidemiology
Description
Summary:CONTEXT: The scarcity of cross-national reports and the changes in Diagnostic and Statistical Manual version 5 (DSM-5) regarding panic disorder (PD) and panic attacks (PAs) call for new epidemiological data on PD and PAs and its subtypes in the general population. OBJECTIVE: To present representative data about the cross-national epidemiology of PD and PAs in accordance with DSM-5 definitions. DESIGN AND SETTING: Nationally representative cross-sectional surveys using the World Health Organization Composite International Diagnostic Interview version 3.0. PARTICIPANTS: Respondents (n = 142,949) from 25 high, middle, and lower-middle income countries across the world aged 18 years or older. MAIN OUTCOME MEASURES: PD and presence of single and recurrent PAs. RESULTS: Lifetime prevalence of PAs was 13.2% (SE 0.1%). Among persons that ever had a PA, the majority had recurrent PAs (66.5%; SE 0.5%), while only 12.8% fulfilled DSM-5 criteria for PD. Recurrent PAs were associated with a subsequent onset of a variety of mental disorders (OR 2.0; 95% CI 1.8-2.2) and their course (OR 1.3; 95% CI 1.2-2.4) whereas single PAs were not (OR 1.1; 95% CI 0.9-1.3 and OR 0.7; 95% CI 0.6-0.8). Cross-national lifetime prevalence estimates were 1.7% (SE 0.0%) for PD with a median age of onset of 32 (IQR 20-47). Some 80.4% of persons with lifetime PD had a lifetime comorbid mental disorder. CONCLUSIONS: We extended previous epidemiological data to a cross-national context. The presence of recurrent PAs in particular is associated with subsequent onset and course of mental disorders beyond agoraphobia and PD, and might serve as a generic risk marker for psychopathology.

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