Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson's Disease Patients: A 2-Year Follow-Up Study
Objective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson's disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients without MF at baseline, who were recruited from January 2016 to November 2017...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:fisabio.fundanetsuite.com:p13758 |
| Acceso en línea: | https://fisabio.portalinvestigacion.com/publicaciones/13758 |
| Access Level: | acceso abierto |
| Palabra clave: | burden follow-up non-motor symptoms motor fluctuations Parkinson's disease |
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Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson's Disease Patients: A 2-Year Follow-Up StudySantos-Garcia, DFonticoba, TDBartolome, CCPainceiras, MJFCastro, ESCanfield, HMiro, CMJesus, SAguilar, MPastor, PPlanellas, LCosgaya, MCaldentey, JGCaballol, NLegarda, IHernandez-Vara, JCabo, IManzanares, LLAramburu, IGRivera, MAAMayordomo, VGNogueira, VPuente, VGarcia-Soto, JDBorrue, CVila, BSSauco, MAVela, LEscalante, SCubo, EPadilla, FCCastrillo, JCMAlonso, PSLosada, MGAAriztegui, NLGaston, IKulisevsky, JEstrada, MBSeijo, MMartinez, JRValero, CKurtis, Mde Fabregues, OArdura, JGRedondo, RAOrdas, CDiaz, LMLMcAfee, DMartinez-Martin, PMir, Pburdenfollow-upnon-motor symptomsmotor fluctuationsParkinson's diseaseObjective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson's disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. MF development at V2 was defined as a score >= 1 in the item-39 of the UPDRS-Part IV, whereas NMS burden was defined according to the Non-motor Symptoms Scale (NMSS) total score. Results: Three hundred and thirty PD patients (62.67 +/- 8.7 years old; 58.8% males) were included. From V0 to V2, 27.6% of the patients developed MF. The mean NMSS total score at baseline was higher in those patients who developed MF after the 2-year follow-up (46.34 +/- 36.48 vs. 34.3 +/- 29.07; p = 0.001). A greater increase in the NMSS total score from V0 to V2 was observed in patients who developed MF (+16.07 +/- 37.37) compared to those who did not develop MF (+6.2 +/- 25.8) (p = 0.021). Development of MF after a 2-year follow-up was associated with an increase in the NMSS total score (beta = 0.128; p = 0.046) after adjustment to age, gender, years from symptoms onset, levodopa equivalent daily dose (LEDD) and the NMSS total score at baseline, and the change in LEDD from V0 to V2. Conclusions: In PD patients, the development of MF is associated with a greater increase in the NMS burden after a 2-year follow-up.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/13758DiagnosticsISSN: 20754418reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p137582026-06-11T12:45:17Z |
| dc.title.none.fl_str_mv |
Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson's Disease Patients: A 2-Year Follow-Up Study |
| title |
Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson's Disease Patients: A 2-Year Follow-Up Study |
| spellingShingle |
Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson's Disease Patients: A 2-Year Follow-Up Study Santos-Garcia, D burden follow-up non-motor symptoms motor fluctuations Parkinson's disease |
| title_short |
Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson's Disease Patients: A 2-Year Follow-Up Study |
| title_full |
Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson's Disease Patients: A 2-Year Follow-Up Study |
| title_fullStr |
Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson's Disease Patients: A 2-Year Follow-Up Study |
| title_full_unstemmed |
Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson's Disease Patients: A 2-Year Follow-Up Study |
| title_sort |
Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson's Disease Patients: A 2-Year Follow-Up Study |
| dc.creator.none.fl_str_mv |
Santos-Garcia, D Fonticoba, TD Bartolome, CC Painceiras, MJF Castro, ES Canfield, H Miro, CM Jesus, S Aguilar, M Pastor, P Planellas, L Cosgaya, M Caldentey, JG Caballol, N Legarda, I Hernandez-Vara, J Cabo, I Manzanares, LL Aramburu, IG Rivera, MAA Mayordomo, VG Nogueira, V Puente, V Garcia-Soto, JD Borrue, C Vila, BS Sauco, MA Vela, L Escalante, S Cubo, E Padilla, FC Castrillo, JCM Alonso, PS Losada, MGA Ariztegui, NL Gaston, I Kulisevsky, J Estrada, MB Seijo, M Martinez, JR Valero, C Kurtis, M de Fabregues, O Ardura, JG Redondo, RA Ordas, C Diaz, LML McAfee, D Martinez-Martin, P Mir, P |
| author |
Santos-Garcia, D |
| author_facet |
Santos-Garcia, D Fonticoba, TD Bartolome, CC Painceiras, MJF Castro, ES Canfield, H Miro, CM Jesus, S Aguilar, M Pastor, P Planellas, L Cosgaya, M Caldentey, JG Caballol, N Legarda, I Hernandez-Vara, J Cabo, I Manzanares, LL Aramburu, IG Rivera, MAA Mayordomo, VG Nogueira, V Puente, V Garcia-Soto, JD Borrue, C Vila, BS Sauco, MA Vela, L Escalante, S Cubo, E Padilla, FC Castrillo, JCM Alonso, PS Losada, MGA Ariztegui, NL Gaston, I Kulisevsky, J Estrada, MB Seijo, M Martinez, JR Valero, C Kurtis, M de Fabregues, O Ardura, JG Redondo, RA Ordas, C Diaz, LML McAfee, D Martinez-Martin, P Mir, P |
| author_role |
author |
| author2 |
Fonticoba, TD Bartolome, CC Painceiras, MJF Castro, ES Canfield, H Miro, CM Jesus, S Aguilar, M Pastor, P Planellas, L Cosgaya, M Caldentey, JG Caballol, N Legarda, I Hernandez-Vara, J Cabo, I Manzanares, LL Aramburu, IG Rivera, MAA Mayordomo, VG Nogueira, V Puente, V Garcia-Soto, JD Borrue, C Vila, BS Sauco, MA Vela, L Escalante, S Cubo, E Padilla, FC Castrillo, JCM Alonso, PS Losada, MGA Ariztegui, NL Gaston, I Kulisevsky, J Estrada, MB Seijo, M Martinez, JR Valero, C Kurtis, M de Fabregues, O Ardura, JG Redondo, RA Ordas, C Diaz, LML McAfee, D Martinez-Martin, P Mir, P |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
burden follow-up non-motor symptoms motor fluctuations Parkinson's disease |
| topic |
burden follow-up non-motor symptoms motor fluctuations Parkinson's disease |
| description |
Objective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson's disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. MF development at V2 was defined as a score >= 1 in the item-39 of the UPDRS-Part IV, whereas NMS burden was defined according to the Non-motor Symptoms Scale (NMSS) total score. Results: Three hundred and thirty PD patients (62.67 +/- 8.7 years old; 58.8% males) were included. From V0 to V2, 27.6% of the patients developed MF. The mean NMSS total score at baseline was higher in those patients who developed MF after the 2-year follow-up (46.34 +/- 36.48 vs. 34.3 +/- 29.07; p = 0.001). A greater increase in the NMSS total score from V0 to V2 was observed in patients who developed MF (+16.07 +/- 37.37) compared to those who did not develop MF (+6.2 +/- 25.8) (p = 0.021). Development of MF after a 2-year follow-up was associated with an increase in the NMSS total score (beta = 0.128; p = 0.046) after adjustment to age, gender, years from symptoms onset, levodopa equivalent daily dose (LEDD) and the NMSS total score at baseline, and the change in LEDD from V0 to V2. Conclusions: In PD patients, the development of MF is associated with a greater increase in the NMS burden after a 2-year follow-up. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://fisabio.portalinvestigacion.com/publicaciones/13758 |
| url |
https://fisabio.portalinvestigacion.com/publicaciones/13758 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
MDPI |
| publisher.none.fl_str_mv |
MDPI |
| dc.source.none.fl_str_mv |
Diagnostics ISSN: 20754418 reponame:r-FISABIO. Repositorio Institucional de Producción Científica instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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r-FISABIO. Repositorio Institucional de Producción Científica |
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1869410306867855360 |
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15.812429 |