Motor Fluctuations Development Is Associated with Non-Mostor Symptoms Burden Progression in Parkinson's Disease Patients

The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson's disease (PD) patients regarding the development of motor fluctuations (MF). PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated...

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Autores: Santos García, Diego|||0000-0002-3126-5111, de Deus Fonticoba, Teresa, Cores Bartolomé, Carlos|||0000-0002-8352-2263, Feal Painceiras, Maria J., Suárez Castro, Ester, Canfield Medina, H., Martínez Miró, Cristina|||0000-0003-3968-5441, Jesús, Silvia, Aguilar Barberà, Miquel, Pastor, Pau|||0000-0002-7493-8777, Planellas, Lluis|||0000-0002-0769-6675, Cosgaya, Marina, García Caldentey, Juan, Caballol, Nuria|||0000-0003-3363-3077, Legarda, Inés, Hernández-Vara, Jorge|||0000-0002-9129-5224, Cabo-Lopez, Iria|||0000-0003-2436-6499, López Manzanares, Lydia|||0000-0003-4615-4542, Gonzalez-Aramburu, Isabel|||0000-0002-3696-4093, Ávila Rivera, Maria A., Gómez Mayordomo, Víctor|||0000-0001-9343-8439, Nogueira, Víctor, Puente, Víctor, Dotor García-Soto, Julio, Borrué, Carmen, Solano Vila, Berta|||0009-0007-8945-0487, Álvarez Sauco, María, Vela, Lydia|||0000-0001-6663-395X, Escalante, Sonia|||0000-0001-8931-1400, Cubo, Esther|||0000-0003-0018-1182, Carrillo Padilla, Francisco, Martínez-Castrillo, Juan Carlos|||0000-0001-7744-6850, Sánchez Alonso, Pilar|||0000-0003-0496-4707, Alonso Losada, Maria G., López Ariztegui, Nuria|||0000-0001-7172-3191, Gastón, Itziar, Kulisevsky, Jaime|||0000-0003-4870-1431, Blázquez Estrada, Marta|||0000-0003-3348-9992, Seijo, Manuel, Ruiz Martínez, Javier|||0000-0001-7326-6270, Valero, Caridad, Kurtis, Mónica|||0000-0003-3037-9712, Fàbregues-Boixar i Nebot, Oriol de|||0000-0002-3518-5338, González Ardura, Jessica, Alonso Redondo, Ruben, Ordás Bandera, Carlos Manuel|||0000-0003-3551-8769, López Díaz, Luis M., McAfee, Darrian, Martinez-Martin, Pablo|||0000-0003-0837-5280, Mir, Pablo|||0000-0003-1656-302X, Santacruz, Pilar, Pascual Sedano, Berta María|||0000-0002-9298-8241, Pagonabarraga Mora, Javier|||0000-0002-3248-704X, Martí, Maria José, Martí-Andres, Gloria|||0000-0001-6474-8454, Lucas-del-Pozo, Sara|||0000-0002-5431-8204, Horta-Barba, Andrea|||0000-0003-0050-5466, Crespo Cuevas, Ane Miren|||0000-0003-1400-5809, Cámara Lorenzo, Ana, Bejr-kasem, Helena|||0000-0001-8828-5976
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:290566
Acceso en línea:https://ddd.uab.cat/record/290566
https://dx.doi.org/urn:doi:10.3390/diagnostics12051147
Access Level:acceso abierto
Palabra clave:Parkinson's disease
Burden
Follow-up
Motor fluctuations
Non-motor symptoms
Descripción
Sumario:The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson's disease (PD) patients regarding the development of motor fluctuations (MF). PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. MF development at V2 was defined as a score ≥ 1 in the item-39 of the UPDRS-Part IV, whereas NMS burden was defined according to the Non-motor Symptoms Scale (NMSS) total score. Three hundred and thirty PD patients (62.67 ± 8.7 years old; 58.8% males) were included. From V0 to V2, 27.6% of the patients developed MF. The mean NMSS total score at baseline was higher in those patients who developed MF after the 2-year follow-up (46.34 ± 36.48 vs. 34.3 ± 29.07; p = 0.001). A greater increase in the NMSS total score from V0 to V2 was observed in patients who developed MF (+16.07 ± 37.37) compared to those who did not develop MF (+6.2 ± 25.8) (p = 0.021). Development of MF after a 2-year follow-up was associated with an increase in the NMSS total score (β = 0.128; p = 0.046) after adjustment to age, gender, years from symptoms onset, levodopa equivalent daily dose (LEDD) and the NMSS total score at baseline, and the change in LEDD from V0 to V2. In PD patients, the development of MF is associated with a greater increase in the NMS burden after a 2-year follow-up.

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