Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease
Background and objective: Sex plays a role in Parkinson's disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Recursos: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p16057 |
| Acesso em linha: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16057 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149134153&doi=10.3390%2fjcm12041329&partnerID=40&md5=0a748ed187911b0a1b8db9796146b383 |
| Access Level: | acceso abierto |
| Palavra-chave: | motor non-motor symptoms gender Parkinson's disease quality of life sex |
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Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's DiseaseSantos-Garcia, DLaguna, AHernandez-Vara, JFonticoba, TDBartolome, CCPainceiras, MJFIniguez-Alvarado, MCDiaz, IGJesus, SBoungiorno, MTPlanellas, LCosgaya, MCaldentey, JGCaballol, NLegarda, ICabo, IManzanares, LLAramburu, IGRivera, MAAMayordomo, VGNogueira, VPuente, VGarcia-Soto, JDBorrue, CVila, BSSauco, MAVela, LEscalante, SCubo, EPadilla, FCCastrillo, JCMAlonso, PSLosada, MGAAriztegui, NLGaston, IKulisevsky, JGonzalez, MMSeijo, MMartinez, JRValero, CKurtis, MArdura, JGRedondo, RAOrdas, CDiaz, LMLMcAfee, DMartinez-Martin, PMir, Pmotornon-motor symptomsgenderParkinson's diseasequality of lifesexBackground and objective: Sex plays a role in Parkinson's disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 +/- 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 +/- 8.73 vs. 62.8 +/- 9.24; p = 0.297) or in the time from symptoms onset (5.66 +/- 4.65 vs. 5.21 +/- 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16057https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149134153&doi=10.3390%2fjcm12041329&partnerID=40&md5=0a748ed187911b0a1b8db9796146b383Journal of Clinical MedicineISSN: 20770383reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p160572026-06-14T12:41:47Z |
| dc.title.none.fl_str_mv |
Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease |
| title |
Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease |
| spellingShingle |
Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease Santos-Garcia, D motor non-motor symptoms gender Parkinson's disease quality of life sex |
| title_short |
Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease |
| title_full |
Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease |
| title_fullStr |
Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease |
| title_full_unstemmed |
Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease |
| title_sort |
Sex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson's Disease |
| dc.creator.none.fl_str_mv |
Santos-Garcia, D Laguna, A Hernandez-Vara, J Fonticoba, TD Bartolome, CC Painceiras, MJF Iniguez-Alvarado, MC Diaz, IG Jesus, S Boungiorno, MT Planellas, L Cosgaya, M Caldentey, JG Caballol, N Legarda, I Cabo, I Manzanares, LL Aramburu, IG Rivera, MAA Mayordomo, VG Nogueira, V Puente, V Garcia-Soto, JD Borrue, C Vila, BS Sauco, MA Vela, L Escalante, S Cubo, E Padilla, FC Castrillo, JCM Alonso, PS Losada, MGA Ariztegui, NL Gaston, I Kulisevsky, J Gonzalez, MM Seijo, M Martinez, JR Valero, C Kurtis, M Ardura, JG Redondo, RA Ordas, C Diaz, LML McAfee, D Martinez-Martin, P Mir, P |
| author |
Santos-Garcia, D |
| author_facet |
Santos-Garcia, D Laguna, A Hernandez-Vara, J Fonticoba, TD Bartolome, CC Painceiras, MJF Iniguez-Alvarado, MC Diaz, IG Jesus, S Boungiorno, MT Planellas, L Cosgaya, M Caldentey, JG Caballol, N Legarda, I Cabo, I Manzanares, LL Aramburu, IG Rivera, MAA Mayordomo, VG Nogueira, V Puente, V Garcia-Soto, JD Borrue, C Vila, BS Sauco, MA Vela, L Escalante, S Cubo, E Padilla, FC Castrillo, JCM Alonso, PS Losada, MGA Ariztegui, NL Gaston, I Kulisevsky, J Gonzalez, MM Seijo, M Martinez, JR Valero, C Kurtis, M Ardura, JG Redondo, RA Ordas, C Diaz, LML McAfee, D Martinez-Martin, P Mir, P |
| author_role |
author |
| author2 |
Laguna, A Hernandez-Vara, J Fonticoba, TD Bartolome, CC Painceiras, MJF Iniguez-Alvarado, MC Diaz, IG Jesus, S Boungiorno, MT Planellas, L Cosgaya, M Caldentey, JG Caballol, N Legarda, I Cabo, I Manzanares, LL Aramburu, IG Rivera, MAA Mayordomo, VG Nogueira, V Puente, V Garcia-Soto, JD Borrue, C Vila, BS Sauco, MA Vela, L Escalante, S Cubo, E Padilla, FC Castrillo, JCM Alonso, PS Losada, MGA Ariztegui, NL Gaston, I Kulisevsky, J Gonzalez, MM Seijo, M Martinez, JR Valero, C Kurtis, M Ardura, JG Redondo, RA Ordas, C Diaz, LML McAfee, D Martinez-Martin, P Mir, P |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
motor non-motor symptoms gender Parkinson's disease quality of life sex |
| topic |
motor non-motor symptoms gender Parkinson's disease quality of life sex |
| description |
Background and objective: Sex plays a role in Parkinson's disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 +/- 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 +/- 8.73 vs. 62.8 +/- 9.24; p = 0.297) or in the time from symptoms onset (5.66 +/- 4.65 vs. 5.21 +/- 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16057 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149134153&doi=10.3390%2fjcm12041329&partnerID=40&md5=0a748ed187911b0a1b8db9796146b383 |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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MDPI |
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MDPI |
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Journal of Clinical Medicine ISSN: 20770383 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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