Developing an anatomically valid segmentation protocol for anterior regions of the medial temporal lobe for neurodegenerative diseases

The anterior portion of the medial temporal lobe (MTL) is one of the first regions targeted by pathology in sporadic Alzheimer'sdisease (AD) and limbic-predominant age-related TDP- 43 encephalopathy (LATE) indicating a potential for metrics from thisregion to serve as imaging biomarkers. Le...

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Detalhes bibliográficos
Autores: Sadeghpour, Niyousha, Lim, Sydney A., Wuestefeld, Anika, Denning, Amanda E., Ittyerah, Ranjit, Trotman, Winifred, Chung, Eunice, Sadaghiani, Shokufeh, Prabhakaran, Karthik, Bedard, Madigan L., Ohm, Daniel T., Artacho Pérula, Emilio, Iñiguez de Onzoño, María Mercedes, Muñoz López, Mónica, Molina Romero, Francisco Javier, Delgado González, José Carlos, Arroyo-Jiménez, María del Mar, Marcos Rabal, María del, Insausti Serrano, Ana María, Vilaseca González, Noemí, Cebada Sánchez, Sandra, Rosa-Prieto, Carlos de la, Insausti, Ricardo, McMillan, Corey, Lee, Edward B., Detre, John A., Das, Sandhitsu R., Xie, Long, Tisdall, M. Dylan, Irwin, David J., Wolk, David A., Yushkevich, Paul, Wisse, Laura E. M.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Universidad Pública de Navarra
Repositório:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/55586
Acesso em linha:https://hdl.handle.net/2454/55586
Access Level:Acceso aberto
Palavra-chave:Alzheimer&apos
s disease
Imaging biomarkers
Medial temporal lobe
Segmentation protocol
Descrição
Resumo:The anterior portion of the medial temporal lobe (MTL) is one of the first regions targeted by pathology in sporadic Alzheimer'sdisease (AD) and limbic-predominant age-related TDP- 43 encephalopathy (LATE) indicating a potential for metrics from thisregion to serve as imaging biomarkers. Leveraging a unique post-mortem dataset of histology and magnetic resonance imag-ing (MRI) scans, we aimed to (1) develop an anatomically valid segmentation protocol for anterior entorhinal cortex (ERC),Brodmann area (BA) 35, and BA36 for in vivo 3 T MRI and (2) incorporate this protocol in an automated approach. We included20 cases (61–97 years old, 50% females) with and without neurodegenerative diseases (11 vs. 9 cases) to ensure generalizability ofthe developed protocol. Digitized MTL Nissl-stained coronal histology sections from these cases were annotated and registeredto same-subject post-mortem MRI. The protocol was developed by determining the location of histological borders of the MTLcortices in relation to anatomical landmarks. Subsequently, the protocol was applied to 15 cases twice, with a 2-week interval,to assess intra-rater reliability with the Dice Similarity Index (DSI). Thereafter, it was implemented in our in-house AutomaticSegmentation of Hippocampal Subfields (ASHS)-T1 approach and evaluated with DSIs. The anterior histological border dis-tances of ERC, BA35 and BA36 were evaluated with respect to various anatomical landmarks, and the distance relative to the be-ginning of the hippocampus was chosen. To formulate segmentation rules, we examined the histological sections for the location of borders in relationship to anatomical landmarks in the coronal sections. The DSI for the anterior MTL cortices for the intra-rater reliability was 0.85–0.88, and for the ASHS-T1 against the manual segmentation, it was 0.62–0.65. We developed a reliablesegmentation protocol and incorporated it in an automated approach. Given the vulnerability of the anterior MTL cortices to taudeposition in AD and LATE, the updated approach is expected to improve imaging biomarkers for these diseases.

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