Developing an Anatomically Valid Segmentation Protocol for Anterior Regions of the Medial Temporal Lobe for Neurodegenerative Diseases

The anterior portion of the medial temporal lobe (MTL) is one of the first regions targeted by pathology in sporadic Alzheimers disease (AD) and limbic-predominant age-related TDP-43 encephalopathy (LATE) indicating a potential for metrics from this region to serve as imaging biomarkers. Leveraging...

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Detalles Bibliográficos
Autores: Sadeghpour, Niyousha, Lim, Sydney A., Wuestefeld, Anika, Denning, Amanda E., Ittyerah, Ranjit, Trotman, Winifred, Chung, Eunice, Sadaghiani, Shokufeh, Prabhakaran, Karthik, Bedard, Madigan L., Ohm, Daniel T., Artacho Pérula, Emilio, Íñiguez de Onzoño Martín, María Mercedes, Muñoz López, Mónica, Molina Romero, Francisco Javier, Delgado González, José Carlos, Arroyo Jiménez, María del Mar, Marcos Rabal, María del Pilar, Insausti Serrano, Ana María, Villaseca González, Noemí, Cebada Sánchez, Sandra, Rosa Prieto, Carlos de la, Insausti Serrano, Ricardo, McMillan, Corey, Lee, Edward B., Detre, John A., Das, Sandhitsu R., Xie, Long, Tisdall, M. Dylan, Irwin, David J., Wolk, David A., Yushkevich, Paul A., Wisse, Laura E. M.
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/45061
Acceso en línea:https://pmc.ncbi.nlm.nih.gov/articles/PMC12361719/pdf/HIPO-35-0.pdf
https://hdl.handle.net/10578/45061
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Imaging biomarkers
Medial temporal lobe
Descripción
Sumario:The anterior portion of the medial temporal lobe (MTL) is one of the first regions targeted by pathology in sporadic Alzheimers disease (AD) and limbic-predominant age-related TDP-43 encephalopathy (LATE) indicating a potential for metrics from this region to serve as imaging biomarkers. Leveraging a unique post-mortem dataset of histology and magnetic resonance imaging (MRI) scans, we aimed to (1) develop an anatomically valid segmentation protocol for anterior entorhinal cortex (ERC), Brodmann area (BA) 35, and BA36 for in vivo 3 T MRI and (2) incorporate this protocol in an automated approach. We included 20 cases (61-97 years old, 50% females) with and without neurodegenerative diseases (11 vs. 9 cases) to ensure generalizability of the developed protocol. Digitized MTL Nissl-stained coronal histology sections from these cases were annotated and registered to same-subject post-mortem MRI. The protocol was developed by determining the location of histological borders of the MTL cortices in relation to anatomical landmarks. Subsequently, the protocol was applied to 15 cases twice, with a 2-week interval, to assess intra-rater reliability with the Dice Similarity Index (DSI). Thereafter, it was implemented in our in-house Automatic Segmentation of Hippocampal Subfields (ASHS)-T1 approach and evaluated with DSIs. The anterior histological border distances of ERC, BA35 and BA36 were evaluated with respect to various anatomical landmarks, and the distance relative to the beginning of the hippocampus was chosen. To formulate segmentation rules, we examined the histological sections for the location of borders in relationship to anatomical landmarks in the coronal sections. The DSI for the anterior MTL cortices for the intra-rater reliability was 0.85-0.88, and for the ASHS-T1 against the manual segmentation, it was 0.62-0.65. We developed a reliable segmentation protocol and incorporated it in an automated approach. Given the vulnerability of the anterior MTL cortices to tau deposition in AD and LATE, the updated approach is expected to improve imaging biomarkers for these diseases.

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