Polylysine-based complex coacervates as pH-Responsive carriers for doxorubicin hydrochloride

Complex coacervation is a versatile and efficient technique for encapsulating bioactive molecules, with broad applications in the food and pharmaceutical industries. The process relies on the cooperative electrostatic interaction between oppositely charged polyelectrolytes in aqueous media. In this...

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Autores: Haro Gutiérrez, Pilar Adriana, Barba Godinez, Jonathan Michel|||0009-0003-2842-0103, García Carvajal, Zaira Yunuen, Tinajero, Ernesto|||0000-0001-5993-8114
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/448604
Acceso en línea:https://hdl.handle.net/2117/448604
https://dx.doi.org/10.1002/pat.70292
Access Level:acceso embargado
Palabra clave:Complex coacervate
Drug delivery
Pectin
Polylysines
Polypeptides
Àrees temàtiques de la UPC::Enginyeria química
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spelling Polylysine-based complex coacervates as pH-Responsive carriers for doxorubicin hydrochlorideHaro Gutiérrez, Pilar AdrianaBarba Godinez, Jonathan Michel|||0009-0003-2842-0103García Carvajal, Zaira YunuenTinajero, Ernesto|||0000-0001-5993-8114Complex coacervateDrug deliveryPectinPolylysinesPolypeptidesÀrees temàtiques de la UPC::Enginyeria químicaComplex coacervation is a versatile and efficient technique for encapsulating bioactive molecules, with broad applications in the food and pharmaceutical industries. The process relies on the cooperative electrostatic interaction between oppositely charged polyelectrolytes in aqueous media. In this study, we present a simple and effective strategy for preparing polyelectrolyte complexes (PECs) using polylysines as cationic polypeptides and pectin as the anionic counterpart. Specifically, we utilized biosynthetically produced epsilon-polylysine (ePL), an emerging and accessible polypeptide, to develop pH-responsive nanocarriers for the encapsulation and controlled release of doxorubicin hydrochloride. Our coacervation-based approach achieved high encapsulation efficiencies, with successful pH-triggered drug release via complex dissociation. This simple ePL-based PEC formulation, using accessible biopolymers, shows promise for drug delivery applications.Peer Reviewed20252025-08-0120252025-12-0420262026-08-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/448604https://dx.doi.org/10.1002/pat.70292reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengembargoed accesshttp://purl.org/coar/access_right/c_f1cfAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/embargoedAccessoai:upcommons.upc.edu:2117/4486042026-05-27T15:37:01Z
dc.title.none.fl_str_mv Polylysine-based complex coacervates as pH-Responsive carriers for doxorubicin hydrochloride
title Polylysine-based complex coacervates as pH-Responsive carriers for doxorubicin hydrochloride
spellingShingle Polylysine-based complex coacervates as pH-Responsive carriers for doxorubicin hydrochloride
Haro Gutiérrez, Pilar Adriana
Complex coacervate
Drug delivery
Pectin
Polylysines
Polypeptides
Àrees temàtiques de la UPC::Enginyeria química
title_short Polylysine-based complex coacervates as pH-Responsive carriers for doxorubicin hydrochloride
title_full Polylysine-based complex coacervates as pH-Responsive carriers for doxorubicin hydrochloride
title_fullStr Polylysine-based complex coacervates as pH-Responsive carriers for doxorubicin hydrochloride
title_full_unstemmed Polylysine-based complex coacervates as pH-Responsive carriers for doxorubicin hydrochloride
title_sort Polylysine-based complex coacervates as pH-Responsive carriers for doxorubicin hydrochloride
dc.creator.none.fl_str_mv Haro Gutiérrez, Pilar Adriana
Barba Godinez, Jonathan Michel|||0009-0003-2842-0103
García Carvajal, Zaira Yunuen
Tinajero, Ernesto|||0000-0001-5993-8114
author Haro Gutiérrez, Pilar Adriana
author_facet Haro Gutiérrez, Pilar Adriana
Barba Godinez, Jonathan Michel|||0009-0003-2842-0103
García Carvajal, Zaira Yunuen
Tinajero, Ernesto|||0000-0001-5993-8114
author_role author
author2 Barba Godinez, Jonathan Michel|||0009-0003-2842-0103
García Carvajal, Zaira Yunuen
Tinajero, Ernesto|||0000-0001-5993-8114
author2_role author
author
author
dc.subject.none.fl_str_mv Complex coacervate
Drug delivery
Pectin
Polylysines
Polypeptides
Àrees temàtiques de la UPC::Enginyeria química
topic Complex coacervate
Drug delivery
Pectin
Polylysines
Polypeptides
Àrees temàtiques de la UPC::Enginyeria química
description Complex coacervation is a versatile and efficient technique for encapsulating bioactive molecules, with broad applications in the food and pharmaceutical industries. The process relies on the cooperative electrostatic interaction between oppositely charged polyelectrolytes in aqueous media. In this study, we present a simple and effective strategy for preparing polyelectrolyte complexes (PECs) using polylysines as cationic polypeptides and pectin as the anionic counterpart. Specifically, we utilized biosynthetically produced epsilon-polylysine (ePL), an emerging and accessible polypeptide, to develop pH-responsive nanocarriers for the encapsulation and controlled release of doxorubicin hydrochloride. Our coacervation-based approach achieved high encapsulation efficiencies, with successful pH-triggered drug release via complex dissociation. This simple ePL-based PEC formulation, using accessible biopolymers, shows promise for drug delivery applications.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-08-01
2025
2025-12-04
2026
2026-08-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/448604
https://dx.doi.org/10.1002/pat.70292
url https://hdl.handle.net/2117/448604
https://dx.doi.org/10.1002/pat.70292
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv embargoed access
http://purl.org/coar/access_right/c_f1cf
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv embargoed access
http://purl.org/coar/access_right/c_f1cf
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
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