Polylysine-based complex coacervates as pH-Responsive carriers for doxorubicin hydrochloride
Complex coacervation is a versatile and efficient technique for encapsulating bioactive molecules, with broad applications in the food and pharmaceutical industries. The process relies on the cooperative electrostatic interaction between oppositely charged polyelectrolytes in aqueous media. In this...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/448604 |
| Acceso en línea: | https://hdl.handle.net/2117/448604 https://dx.doi.org/10.1002/pat.70292 |
| Access Level: | acceso embargado |
| Palabra clave: | Complex coacervate Drug delivery Pectin Polylysines Polypeptides Àrees temàtiques de la UPC::Enginyeria química |
| Sumario: | Complex coacervation is a versatile and efficient technique for encapsulating bioactive molecules, with broad applications in the food and pharmaceutical industries. The process relies on the cooperative electrostatic interaction between oppositely charged polyelectrolytes in aqueous media. In this study, we present a simple and effective strategy for preparing polyelectrolyte complexes (PECs) using polylysines as cationic polypeptides and pectin as the anionic counterpart. Specifically, we utilized biosynthetically produced epsilon-polylysine (ePL), an emerging and accessible polypeptide, to develop pH-responsive nanocarriers for the encapsulation and controlled release of doxorubicin hydrochloride. Our coacervation-based approach achieved high encapsulation efficiencies, with successful pH-triggered drug release via complex dissociation. This simple ePL-based PEC formulation, using accessible biopolymers, shows promise for drug delivery applications. |
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