Laser-driven radiation sources for in vitro radiobiological studies

Laser-driven radiation sources have emerged as a compact and promising alternative to conventional large-scale accelerators for radiobiological research. However, their application in this field remains challenging due to limitations in dose control, reproducibility, and beam stability. This thesis...

ver descrição completa

Detalhes bibliográficos
Autor: Reija Vecino, Alicia
Tipo de documento: tese
Data de publicação:2026
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositório:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglês
OAI Identifier:oai:dnet:minerva_____::869cd0eb2d807cc972fd16b3b9059988
Acesso em linha:https://hdl.handle.net/10347/47565
Access Level:Acceso aberto
Palavra-chave:radiobiology
laser
acceleration
cell
240606 Física médica
220910 Láseres
id ES_6c5cd4957f9f309ea8a28a67d8ad5937
oai_identifier_str oai:dnet:minerva_____::869cd0eb2d807cc972fd16b3b9059988
network_acronym_str ES
network_name_str España
repository_id_str
spelling Laser-driven radiation sources for in vitro radiobiological studiesReija Vecino, Aliciaradiobiologylaseraccelerationcell240606 Física médica220910 LáseresLaser-driven radiation sources have emerged as a compact and promising alternative to conventional large-scale accelerators for radiobiological research. However, their application in this field remains challenging due to limitations in dose control, reproducibility, and beam stability. This thesis investigates the feasibility of employing laser-driven radiation sources for in vitro radiobiological studies, with a particular emphasis on the validation of irradiation experiments performed at high repetition rates. Two independent experimental setups were designed, commissioned, and validated to enable multi-shot irradiation of human lung adenocarcinoma cell cultures using laser-driven x-rays and protons.Benlliure Anaya, JoséSeimetz, MichaelUniversidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)20262026-01-0120262026-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/10347/47565reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:minerva_____::869cd0eb2d807cc972fd16b3b90599882026-06-15T12:47:27Z
dc.title.none.fl_str_mv Laser-driven radiation sources for in vitro radiobiological studies
title Laser-driven radiation sources for in vitro radiobiological studies
spellingShingle Laser-driven radiation sources for in vitro radiobiological studies
Reija Vecino, Alicia
radiobiology
laser
acceleration
cell
240606 Física médica
220910 Láseres
title_short Laser-driven radiation sources for in vitro radiobiological studies
title_full Laser-driven radiation sources for in vitro radiobiological studies
title_fullStr Laser-driven radiation sources for in vitro radiobiological studies
title_full_unstemmed Laser-driven radiation sources for in vitro radiobiological studies
title_sort Laser-driven radiation sources for in vitro radiobiological studies
dc.creator.none.fl_str_mv Reija Vecino, Alicia
author Reija Vecino, Alicia
author_facet Reija Vecino, Alicia
author_role author
dc.contributor.none.fl_str_mv Benlliure Anaya, José
Seimetz, Michael
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS)
dc.subject.none.fl_str_mv radiobiology
laser
acceleration
cell
240606 Física médica
220910 Láseres
topic radiobiology
laser
acceleration
cell
240606 Física médica
220910 Láseres
description Laser-driven radiation sources have emerged as a compact and promising alternative to conventional large-scale accelerators for radiobiological research. However, their application in this field remains challenging due to limitations in dose control, reproducibility, and beam stability. This thesis investigates the feasibility of employing laser-driven radiation sources for in vitro radiobiological studies, with a particular emphasis on the validation of irradiation experiments performed at high repetition rates. Two independent experimental setups were designed, commissioned, and validated to enable multi-shot irradiation of human lung adenocarcinoma cell cultures using laser-driven x-rays and protons.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-01-01
2026
2026-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/47565
url https://hdl.handle.net/10347/47565
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410263063592960
score 15,811543

Registros relacionados