NAD/NADH ratio in Ndufs4−/− macrophages [Dataset]

The NAD/NADH ratio was measured through colorimetric detection in deproteinized cell extracts from parental (Par) and Ndufs4−/− RAW 264.7 cells. *, P <0.05; **, P <0.01; ***, P<0.005; ****, P<0.001. Each point represents a biological replicate. Data are shown as the mean ± SEM.

Detalles Bibliográficos
Autores: Serrano-Lorenzo, Pablo, Gobelli, Dino, Garrido-Moraga, Rocío, Esteban-Amo, María J., López-López, José R., Orduña, Antonio, Fuente, Miguel A. de la, Martín, Miguel Ángel, Simarro-Grande, María
Tipo de recurso: conjunto de datos
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/352332
Acceso en línea:http://hdl.handle.net/10261/352332
Access Level:acceso abierto
Palabra clave:Leigh syndrome patients
Inflammatory cytokine profile
Increasing evidence demonstrate
Div >< p
Mitochondrial respiration alterations
Macrophage effector functions
Effector functions
Maximal respiration
Vitro </
Supernumerary subunit
Shift towards
Phagocytose gram
Ndufs4 </
Mutational hotspot
Modulatory role
Lower levels
Lipopolysaccharide challenge
Improved ability
Critical role
Atp production
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oai_identifier_str oai:digital.csic.es:10261/352332
network_acronym_str ES
network_name_str España
repository_id_str
spelling NAD/NADH ratio in Ndufs4−/− macrophages [Dataset]Serrano-Lorenzo, PabloGobelli, DinoGarrido-Moraga, RocíoEsteban-Amo, María J.López-López, José R.Orduña, AntonioFuente, Miguel A. de laMartín, Miguel ÁngelSimarro-Grande, MaríaLeigh syndrome patientsInflammatory cytokine profileIncreasing evidence demonstrateDiv >< pMitochondrial respiration alterationsMacrophage effector functionsEffector functionsMaximal respirationVitro </Supernumerary subunitShift towardsPhagocytose gramNdufs4 </Mutational hotspotModulatory roleLower levelsLipopolysaccharide challengeImproved abilityCritical roleAtp productionThe NAD/NADH ratio was measured through colorimetric detection in deproteinized cell extracts from parental (Par) and Ndufs4−/− RAW 264.7 cells. *, P <0.05; **, P <0.01; ***, P<0.005; ****, P<0.001. Each point represents a biological replicate. Data are shown as the mean ± SEM.Peer reviewedFigshareConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1Publisher's versioninfo:eu-repo/semantics/publishedVersionimage/tiffhttp://hdl.handle.net/10261/352332reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSerrano-Lorenzo, Pablo; Gobelli, Dino; Garrido-Moraga, Rocío; Esteban-Amo, María J.; López-López, José R.; Orduña, Antonio; Fuente, Miguel A. de la; Martín, Miguel Ángel; Simarro-Grande, María. Development of a novel in vitro model to study the modulatory role of the respiratory complex I in macrophage effector functions. http://dx.doi.org/10.1371/journal.pone.0291442 . http://hdl.handle.net/10261/342166https://doi.org/10.1371/journal.pone.0291442.s006Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3523322026-05-22T06:33:51Z
dc.title.none.fl_str_mv NAD/NADH ratio in Ndufs4−/− macrophages [Dataset]
title NAD/NADH ratio in Ndufs4−/− macrophages [Dataset]
spellingShingle NAD/NADH ratio in Ndufs4−/− macrophages [Dataset]
Serrano-Lorenzo, Pablo
Leigh syndrome patients
Inflammatory cytokine profile
Increasing evidence demonstrate
Div >< p
Mitochondrial respiration alterations
Macrophage effector functions
Effector functions
Maximal respiration
Vitro </
Supernumerary subunit
Shift towards
Phagocytose gram
Ndufs4 </
Mutational hotspot
Modulatory role
Lower levels
Lipopolysaccharide challenge
Improved ability
Critical role
Atp production
title_short NAD/NADH ratio in Ndufs4−/− macrophages [Dataset]
title_full NAD/NADH ratio in Ndufs4−/− macrophages [Dataset]
title_fullStr NAD/NADH ratio in Ndufs4−/− macrophages [Dataset]
title_full_unstemmed NAD/NADH ratio in Ndufs4−/− macrophages [Dataset]
title_sort NAD/NADH ratio in Ndufs4−/− macrophages [Dataset]
dc.creator.none.fl_str_mv Serrano-Lorenzo, Pablo
Gobelli, Dino
Garrido-Moraga, Rocío
Esteban-Amo, María J.
López-López, José R.
Orduña, Antonio
Fuente, Miguel A. de la
Martín, Miguel Ángel
Simarro-Grande, María
author Serrano-Lorenzo, Pablo
author_facet Serrano-Lorenzo, Pablo
Gobelli, Dino
Garrido-Moraga, Rocío
Esteban-Amo, María J.
López-López, José R.
Orduña, Antonio
Fuente, Miguel A. de la
Martín, Miguel Ángel
Simarro-Grande, María
author_role author
author2 Gobelli, Dino
Garrido-Moraga, Rocío
Esteban-Amo, María J.
López-López, José R.
Orduña, Antonio
Fuente, Miguel A. de la
Martín, Miguel Ángel
Simarro-Grande, María
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Leigh syndrome patients
Inflammatory cytokine profile
Increasing evidence demonstrate
Div >< p
Mitochondrial respiration alterations
Macrophage effector functions
Effector functions
Maximal respiration
Vitro </
Supernumerary subunit
Shift towards
Phagocytose gram
Ndufs4 </
Mutational hotspot
Modulatory role
Lower levels
Lipopolysaccharide challenge
Improved ability
Critical role
Atp production
topic Leigh syndrome patients
Inflammatory cytokine profile
Increasing evidence demonstrate
Div >< p
Mitochondrial respiration alterations
Macrophage effector functions
Effector functions
Maximal respiration
Vitro </
Supernumerary subunit
Shift towards
Phagocytose gram
Ndufs4 </
Mutational hotspot
Modulatory role
Lower levels
Lipopolysaccharide challenge
Improved ability
Critical role
Atp production
description The NAD/NADH ratio was measured through colorimetric detection in deproteinized cell extracts from parental (Par) and Ndufs4−/− RAW 264.7 cells. *, P <0.05; **, P <0.01; ***, P<0.005; ****, P<0.001. Each point represents a biological replicate. Data are shown as the mean ± SEM.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
http://purl.org/coar/resource_type/c_ddb1
Publisher's version
info:eu-repo/semantics/publishedVersion
format dataset
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/352332
url http://hdl.handle.net/10261/352332
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Serrano-Lorenzo, Pablo; Gobelli, Dino; Garrido-Moraga, Rocío; Esteban-Amo, María J.; López-López, José R.; Orduña, Antonio; Fuente, Miguel A. de la; Martín, Miguel Ángel; Simarro-Grande, María. Development of a novel in vitro model to study the modulatory role of the respiratory complex I in macrophage effector functions. http://dx.doi.org/10.1371/journal.pone.0291442 . http://hdl.handle.net/10261/342166
https://doi.org/10.1371/journal.pone.0291442.s006
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv image/tiff
dc.publisher.none.fl_str_mv Figshare
publisher.none.fl_str_mv Figshare
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410144021905408
score 15.811543

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