Is DNA Damage Response Ready for Action Anywhere?

Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that...

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Autores: Terrades Ill, Mariona, Martín Flix, Marta|||0000-0001-7849-3616, Hernández Garcia, Laia, Tusell Padrós, Laura|||0000-0002-2848-345X, Genescà, Anna|||0000-0002-0509-956X
Formato: artículo
Fecha de publicación:2012
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:147208
Acesso em linha:https://ddd.uab.cat/record/147208
https://dx.doi.org/urn:doi:10.3390/ijms130911569
Access Level:acceso abierto
Palavra-chave:Micronuclei
DSB repair
NER pathway
Chromosome instability
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spelling Is DNA Damage Response Ready for Action Anywhere?Terrades Ill, MarionaMartín Flix, Marta|||0000-0001-7849-3616Hernández Garcia, LaiaTusell Padrós, Laura|||0000-0002-2848-345XGenescà, Anna|||0000-0002-0509-956XMicronucleiDSB repairNER pathwayChromosome instabilityOrganisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that the condensation state of chromatin hinders a proper DDR. However, the condensation state of chromatin is not the only barrier to DDR. In this review, we have collected data regarding the presence of DDR factors on micronuclear DNA lesions that indicate that micronuclei are almost incapable of generating an effective DDR because of defects in their nuclear envelope. Finally, considering the recent observations about the reincorporation of micronuclei to the main bulk of chromosomes, we suggest that, under certain circumstances, micronuclei carrying DNA damage might be a source of chromosome instability. 22012-01-0120122012-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/147208https://dx.doi.org/urn:doi:10.3390/ijms130911569reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/3.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1472082026-06-06T12:50:31Z
dc.title.none.fl_str_mv Is DNA Damage Response Ready for Action Anywhere?
title Is DNA Damage Response Ready for Action Anywhere?
spellingShingle Is DNA Damage Response Ready for Action Anywhere?
Terrades Ill, Mariona
Micronuclei
DSB repair
NER pathway
Chromosome instability
title_short Is DNA Damage Response Ready for Action Anywhere?
title_full Is DNA Damage Response Ready for Action Anywhere?
title_fullStr Is DNA Damage Response Ready for Action Anywhere?
title_full_unstemmed Is DNA Damage Response Ready for Action Anywhere?
title_sort Is DNA Damage Response Ready for Action Anywhere?
dc.creator.none.fl_str_mv Terrades Ill, Mariona
Martín Flix, Marta|||0000-0001-7849-3616
Hernández Garcia, Laia
Tusell Padrós, Laura|||0000-0002-2848-345X
Genescà, Anna|||0000-0002-0509-956X
author Terrades Ill, Mariona
author_facet Terrades Ill, Mariona
Martín Flix, Marta|||0000-0001-7849-3616
Hernández Garcia, Laia
Tusell Padrós, Laura|||0000-0002-2848-345X
Genescà, Anna|||0000-0002-0509-956X
author_role author
author2 Martín Flix, Marta|||0000-0001-7849-3616
Hernández Garcia, Laia
Tusell Padrós, Laura|||0000-0002-2848-345X
Genescà, Anna|||0000-0002-0509-956X
author2_role author
author
author
author
dc.subject.none.fl_str_mv Micronuclei
DSB repair
NER pathway
Chromosome instability
topic Micronuclei
DSB repair
NER pathway
Chromosome instability
description Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that the condensation state of chromatin hinders a proper DDR. However, the condensation state of chromatin is not the only barrier to DDR. In this review, we have collected data regarding the presence of DDR factors on micronuclear DNA lesions that indicate that micronuclei are almost incapable of generating an effective DDR because of defects in their nuclear envelope. Finally, considering the recent observations about the reincorporation of micronuclei to the main bulk of chromosomes, we suggest that, under certain circumstances, micronuclei carrying DNA damage might be a source of chromosome instability.
publishDate 2012
dc.date.none.fl_str_mv 2
2012-01-01
2012
2012-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/147208
https://dx.doi.org/urn:doi:10.3390/ijms130911569
url https://ddd.uab.cat/record/147208
https://dx.doi.org/urn:doi:10.3390/ijms130911569
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/3.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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