Novelty detection in an auditory oddball task on freely moving rats

The relative importance or saliency of sensory inputs depend on the animal’s environmental context and the behavioural responses to these same inputs can vary over time. Here we show how freely moving rats, trained to discriminate between deviant tones embedded in a regular pattern of repeating stim...

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Detalles Bibliográficos
Autores: Quintela-Vega, Laura, Morado-Díaz, Camilo J., Terreros, Gonzalo, Sánchez Sánchez, Jazmín, Pérez González, David, Malmierca, Manuel S.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/154982
Acceso en línea:http://hdl.handle.net/10366/154982
Access Level:acceso abierto
Palabra clave:Audición
Plasticidad neuronal
Detección
Animal experimentation
Neuronal Plasticity
Brain
Neurons
2410 Biología Humana
3207 Patología
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oai_identifier_str oai:gredos.usal.es:10366/154982
network_acronym_str ES
network_name_str España
repository_id_str
spelling Novelty detection in an auditory oddball task on freely moving ratsQuintela-Vega, LauraMorado-Díaz, Camilo J.Terreros, GonzaloSánchez Sánchez, JazmínPérez González, DavidMalmierca, Manuel S.AudiciónPlasticidad neuronalDetecciónAnimal experimentationNeuronal PlasticityBrainNeurons2410 Biología Humana3207 PatologíaThe relative importance or saliency of sensory inputs depend on the animal’s environmental context and the behavioural responses to these same inputs can vary over time. Here we show how freely moving rats, trained to discriminate between deviant tones embedded in a regular pattern of repeating stimuli and different variations of the classic oddball paradigm, can detect deviant tones, and this discriminability resembles the properties that are typical of neuronal adaptation described in previous studies. Moreover, the auditory brainstem response (ABR) latency decreases after training, a finding consistent with the notion that animals develop a type of plasticity to auditory stimuli. Our study suggests the existence of a form of long-term memory that may modulate the level of neuronal adaptation according to its behavioural relevance, and sets the ground for future experiments that will help to dis- entangle the functional mechanisms that govern behavioural habituation and its relation to neuronal adaptation.202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/154982reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)Inglésinfo:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1549822026-06-07T06:28:51Z
dc.title.none.fl_str_mv Novelty detection in an auditory oddball task on freely moving rats
title Novelty detection in an auditory oddball task on freely moving rats
spellingShingle Novelty detection in an auditory oddball task on freely moving rats
Quintela-Vega, Laura
Audición
Plasticidad neuronal
Detección
Animal experimentation
Neuronal Plasticity
Brain
Neurons
2410 Biología Humana
3207 Patología
title_short Novelty detection in an auditory oddball task on freely moving rats
title_full Novelty detection in an auditory oddball task on freely moving rats
title_fullStr Novelty detection in an auditory oddball task on freely moving rats
title_full_unstemmed Novelty detection in an auditory oddball task on freely moving rats
title_sort Novelty detection in an auditory oddball task on freely moving rats
dc.creator.none.fl_str_mv Quintela-Vega, Laura
Morado-Díaz, Camilo J.
Terreros, Gonzalo
Sánchez Sánchez, Jazmín
Pérez González, David
Malmierca, Manuel S.
author Quintela-Vega, Laura
author_facet Quintela-Vega, Laura
Morado-Díaz, Camilo J.
Terreros, Gonzalo
Sánchez Sánchez, Jazmín
Pérez González, David
Malmierca, Manuel S.
author_role author
author2 Morado-Díaz, Camilo J.
Terreros, Gonzalo
Sánchez Sánchez, Jazmín
Pérez González, David
Malmierca, Manuel S.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Audición
Plasticidad neuronal
Detección
Animal experimentation
Neuronal Plasticity
Brain
Neurons
2410 Biología Humana
3207 Patología
topic Audición
Plasticidad neuronal
Detección
Animal experimentation
Neuronal Plasticity
Brain
Neurons
2410 Biología Humana
3207 Patología
description The relative importance or saliency of sensory inputs depend on the animal’s environmental context and the behavioural responses to these same inputs can vary over time. Here we show how freely moving rats, trained to discriminate between deviant tones embedded in a regular pattern of repeating stimuli and different variations of the classic oddball paradigm, can detect deviant tones, and this discriminability resembles the properties that are typical of neuronal adaptation described in previous studies. Moreover, the auditory brainstem response (ABR) latency decreases after training, a finding consistent with the notion that animals develop a type of plasticity to auditory stimuli. Our study suggests the existence of a form of long-term memory that may modulate the level of neuronal adaptation according to its behavioural relevance, and sets the ground for future experiments that will help to dis- entangle the functional mechanisms that govern behavioural habituation and its relation to neuronal adaptation.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/154982
url http://hdl.handle.net/10366/154982
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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