Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens

Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify ne...

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Detalles Bibliográficos
Autores: Martinez, Isidoro, Oliveros, Juan C., Cuesta, Isabel, de la Barrera, Jorge, Ausina, Vicente, Casals, Cristina, de Lorenzo, Alba, Garcia, Ernesto, Garcia-Fojeda, Belen, Garmendia, Junkal, González-Nicolau, María Del Mar, Lacoma, Alicia, Menendez, Margarita, Moranta, David, Nieto, Amelia, Ortin, Juan, Perez-Gonzalez, Alicia, Prat, Cristina, Ramos-Sevillano, Elisa, Regueiro, Veronica, Rodriguez-Frandsen, Ariel, Solis, Dolores, Yuste, Jose, Bengoechea, Jose Antonio, Melero, Jose A.
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/9927
Acceso en línea:https://hdl.handle.net/20.500.13003/9927
Access Level:acceso abierto
Palabra clave:respiratory pathogens
hostresponse
core of up-regulated genes
bacterial infections
viral infections
Descripción
Sumario:Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.

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