Apoptosis, toll-like, RIG-I-like and NOD-like receptors are pathways jointly induced by diverse respiratory bacterial and viral pathogens

Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify ne...

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Detalhes bibliográficos
Autores: Martínez, Isidoro, Oliveros, Juan C., Cuesta, Isabel, Barrera, Jorge de la, Ausina, Vicente, Casals, Cristina, Lorenzo, Alba de, García, Ernesto, García Fojeda, Belén, Garmendia García, Juncal, González Nicolau, Mar, Lacoma, Alicia, Menéndez, Margarita, Moranta, David, Nieto, Amelia, Ortín, Juan, Pérez González, Alicia, Prat, Cristina, Ramos Sevillano, Elisa, Regueiro, Verónica, Rodríguez Frandsen, Ariel, Solís, Dolores, Yuste, José R., Bengoechea Alonso, José Antonio, Melero, José A.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Recursos:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/30433
Acesso em linha:https://hdl.handle.net/2454/30433
Access Level:acceso abierto
Palavra-chave:Respiratory pathogens
Host response
Core of up-regulated genes
Bacterial infections
Viral infections
Descrição
Resumo:Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.

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