Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study

Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants -mean age 42.8 years at first HRQoL ascertainment, all university graduates-. HRQoL was assessed with the...

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Autores: López-Herreros, J. (J.)|||/items/132486ff-b0e3-4eac-a7ba-cedb87619ce5, Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Sanchez-Villegas, A. (Almudena)|||/items/89570c42-5fec-4682-b219-d901781ef99d, Dierssen-Sotos, T. (T.)|||/items/45298f53-2475-47c8-9d6c-0e845c30a7a9, Jiménez-Moleón, J.J. (José Juan)|||/items/cb714f5d-4da0-4452-8033-a194006facec, Ruiz-Canela, M. (Miguel)|||/items/e333fb32-07a9-4253-a095-1cea0db0f7e9, Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0, Gea, A. (Alfredo)|||/items/0fc6850b-e4e0-4795-960d-db184cd1385f
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/68032
Acceso en línea:https://hdl.handle.net/10171/68032
Access Level:acceso abierto
Palabra clave:SUN project
Health-related quality of life
Cohort
SF-36
Mortality
Descripción
Sumario:Objective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants -mean age 42.8 years at first HRQoL ascertainment, all university graduates-. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16-0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36-0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54-0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46-0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74-0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL -assessed as self-reported health, PCS-36 and MCS-36- obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet.

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