Effect of dietary phenolic compounds intake on mortality in the “Seguimiento Universidad De Navarra” (SUN) Mediterranean cohort
[EN] Plant-based dietary patterns have been demonstrated to reduce the risk of non-communicable disease (NCD), including cardiovascular disease (CVD), type 2 diabetes, cancer, and all-cause mortality. Phenolic compounds (PC), abundant in plant-based foods, have been considered as instrumental in thi...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de León |
| Repositorio: | BULERIA. Repositorio Institucional de la Universidad de León |
| OAI Identifier: | oai:dnet:buleria_____::aec7226b8f6b8f4d37ddd63a11243e2e |
| Acceso en línea: | https://link.springer.com/article/10.1007/s00394-025-03581-5 https://hdl.handle.net/10612/28012 |
| Access Level: | acceso abierto |
| Palabra clave: | Medicina. Salud Dietary phenolic compounds Flavonoids Mortality SUN cohort 3109.06 Nutrición 3202 Epidemiología |
| Sumario: | [EN] Plant-based dietary patterns have been demonstrated to reduce the risk of non-communicable disease (NCD), including cardiovascular disease (CVD), type 2 diabetes, cancer, and all-cause mortality. Phenolic compounds (PC), abundant in plant-based foods, have been considered as instrumental in this attenuation of NCD risk. We evaluated the association between dietary intake of PC and the risk of all-cause mortality in a relatively young Mediterranean cohort of 18,173 Spanish participants in the “Seguimiento Universidad de Navarra” (SUN) project, after a median follow-up of 12.7 years. Intake of PC was estimated at baseline and repeatedly after 10-year follow-up using a 136-item validated food frequency questionnaire and the Phenol-Explorer database. During 236,329 person-years, 544 deaths were confirmed. Cox regression models compared low intake (lowest quintile) vs. high intake (the four upper quintiles merged, as a reference category) of total energy-adjusted PC intake. Adjusted hazard ratios (HR) for low PC intake among those participants aged over 45 years during follow-up were 1.32; 95% CI 1.02–1.71 for all-cause mortality, HR:1.44; 95% CI 1.02–2.02 for cancer mortality; HR: 0.88; 95% CI 0.47–1.66 for CVD mortality and HR: 1.69 95% CI 1.04–2.74 for causes of death other than cancer or CVD. In conclusion, a low intake of total PC was associated with a significantly higher risk of all-cause mortality, and, specifically, a higher risk for cancer in a relatively young cohort. Among PC classes a low intake of flavonoids and phenolic acids showed significant effects for non-cancer/non-CVD mortality. Cherries, chocolate, apples and pears, olives, and coffee, were the major sources of between-person variability for total PC intake in our Mediterranean cohort |
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