Genetic diversity of influenza A(H1N1)2009 virus circulating during the season 2010-2011 in Spain

Background: Genetic diversity of influenza A(H1N1)2009 viruses has been reported since the pandemic virus emerged in April 2009. Different genetic clades have been identified and defined based on amino acid substitutions found in the haemagglutinin (HA) protein sequences. In Spain, circulating influ...

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Detalles Bibliográficos
Autores: Ledesma, Juan, Pozo Sanchez, Francisco, Reina, Gabriel, Blasco, Miriam, Rodríguez, Guadalupe, Montes, Milagrosa, López-Miragaya, Isabel, Salvador, Carmen, Reina, Jordi, Ortíz de Lejarazu, Raúl, Egido, Pilar, López Barba, José, Delgado-Sanz, Concepcion, Cuevas, Maria Teresa, Casas Flecha, Inmaculada, Spanish Influenza Surveillance System (SISS), Larrauri, Amparo, Jimenez-Jorge, Silvia
Tipo de recurso: artículo
Fecha de publicación:2012
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/26136
Acceso en línea:https://hdl.handle.net/20.500.12105/26136
Access Level:acceso abierto
Palabra clave:Influenza A(H1N1)2009
Haemagglutinin
Phylogeny
Amino Acid Substitution
Antigenic Variation
Genes, Viral
Genetic Variation
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Influenza A Virus, H1N1 Subtype
Influenza, Human
Proline
Seasons
Spain
Descripción
Sumario:Background: Genetic diversity of influenza A(H1N1)2009 viruses has been reported since the pandemic virus emerged in April 2009. Different genetic clades have been identified and defined based on amino acid substitutions found in the haemagglutinin (HA) protein sequences. In Spain, circulating influenza viruses are monitored each season by the regional laboratories enrolled in the Spanish Influenza Surveillance System (SISS). The analysis of the HA gene sequence helps to detect the genetic diversity and viral evolution. Objectives: To perform an analysis of the genetic diversity of influenza A(H1N1)2009 viruses circulating in Spain during the season 2010-2011 based on analysis of the HA sequence gene. Study design: Phylogenetic analysis based on the HA1 subunit of the haemagglutinin gene was carried out on 220 influenza A(H1N1)2009 viruses circulating during the season 2010-2011. Results: Six different genetic groups were identified among circulating A(H1N1)2009 viruses, five of them were previously reported during season 2010-2011. A new group, characterized by E172K and K308E changes and a proline at position 83, was observed in 12.27% of the Spanish viruses. Conclusion: Co-circulation of six different genetic groups of influenza A(H1N1)2009 viruses was identified in Spain during the season 2010-2011. Nevertheless, at this stage, none of the groups identified to date have resulted in significant antigenic changes according to data collected by World Health Organization Collaborating Centres for influenza surveillance.

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